Biological Activities of Recombinant Human Follicle Stimulating Hormone
Follicle stimulating hormone (FSH), a member of the glycoprotein hormone family produced in the anterior pituitary, plays a major role in the maturation of ovarian follicles. FSH is a 32-kD heterodimer consisting of 2 noncovalently linked subunits, α and β. Each subunit contains 2 asparagine-linked carbohydrate complexes that are required for full biological activity of the hormone (e.g., circulatory half-life, signal transduction, etc.). Variation in glycosylation patterns at these sites results in multiple hormone isoforms that possess differing biological activities.
KeywordsGranulosa Cell Follicle Stimulate Hormone Follicle Stimulate Hormone Level Follicle Stimulate Hormone Receptor Recombinant Follicle Stimulate Hormone
Unable to display preview. Download preview PDF.
- 1.Smith GM, Bishop LA, DeKroon R, Wright G, Cerpa-Poljak A, Schofield PR. Purification and characterization of recombinant human follicle stimulating hormone, Serono Symposia, USA. (See Chapter 31, this volume.)Google Scholar