Prostate—An Extrapituitary Source of Follicle Stimulating Hormone
The prostate is known to synthesize and secrete various protein hormones, growth factors and neuropeptides, that without any doubt, establish the entity of the prostate as an endocrine organ (1, 2). Our earlier studies had demonstrated the presence of a protein exhibiting inhibin-like activity—prostatic inhibin peptide (PIP)—in prostates of human (3) and animal species (4) that preferentially suppressed synthesis and release of pituitary follicle stimulating hormone (FSH). Since the synthesis and secretion of FSH and inhibin are interdependent (5) and earlier studies also indicated their coexistence in various tissues (6–8), we were prompted to look for FSH in prostates of human and animal species.
KeywordsHPLC Filtration Electrophoresis Paraffin Androgen
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