Use of Purified FSH for In Vitro Fertilization in Humans

  • Zev Rosenwaks
Part of the Serono Symposia USA book series (SERONOSYMP)


The goal of ovarian stimulation for in vitro fertilization (IVF) and embryo transfer (ET) procedures is the recruitment of multiple fertilizable (viable) oocytes. It has long been recognized that patients respond differently in terms of peripheral estradiol levels, number of recruited follicles, and number and quality of oocytes harvested, even when the same stimulation protocols are utilized. Estradiol response patterns have been classified as high, intermediate, or low, depending on the height of the peripheral E2 response levels. We and others have correlated the estradiol response to the quality and number of oocytes retrieved, as well as to the pregnancy outcome. In certain circumstances, manipulation of the stimulation protocols by increasing the dosage of gonadotropin administered in the early follicular phase of the menstrual cycle can improve the stimulation response and pregnancy outcome.


Pregnancy Outcome Embryo Transfer Ovarian Stimulation Ovarian Reserve Stimulation Protocol 
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© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Zev Rosenwaks

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