The Changing Functions of Follicle Stimulating Hormone in the Testes of Prenatal, Newborn, Immature, and Adult Rats

  • Leslie Heckert
  • Michael D. Griswold
Part of the Serono Symposia USA book series (SERONOSYMP)


The target cells for the action of follicle stimulating hormone (FSH) in the testes of mammals are the Sertoli cells (Sc). The function of the Sc includes the physical and biochemical support for germ cell development into spermatozoa. Sc create an environment where germ cells are provided with metabolites, nutrients, and regulatory components. Thus, by exerting influence on the Sc and their functions, FSH indirectly influences spermatogenesis (1, 2). It is evident that in the rat, FSH is necessary to initiate the first wave of spermatogenesis, but its function in the adult rat testis is not well defined (3). The purpose of this manuscript is to review the probable actions of FSH during the development and maturation of the rat testes and describe recent experiments on the ontogeny and expression of the FSH receptor (FSH-R).


Follicle Stimulate Hormone Sertoli Cell Seminiferous Epithelium Follicle Stimulate Hormone Receptor Dibutyryl cAMP 
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© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Leslie Heckert
  • Michael D. Griswold

There are no affiliations available

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