Recombinant FSH and Regulation of Ovulation
The pituitary glycoprotein hormone FSH consists of two dissimilar, noncovalently linked polypeptide chains. The α-subunit is common to all three pituitary glycoprotein hormones (FSH, LH, and TSH) and the placental-derived chorionic gonadotropin (CG). The unique β-subunit confers each molecule with its biological specificity. Although all subunits of the gonadotropins are believed to be derived from a common ancestral gene, each subunit is encoded for by a separate gene. The gene structure of the α- and β-subunits is well conserved, with the FSHβ subunit gene structure identified in 3 exons separated by 2 introns. The FSHβ gene is unique among the glycoprotein hormones in possessing a 3′-untranslated region of approximately 1 kb. The importance of this long 3′ tract is unknown, but is potentially involved in mRNA stability.
KeywordsSialic Acid Granulosa Cell Corpus Luteum Culture Granulosa Cell Carbohydrate Side Chain
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