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Insulin-Like Growth Factors and Their Binding Proteins: Ovarian Modulators of FSH Action

  • James M. Hammond
  • Judith S. Mondschein
  • Susan E. Samaras
  • Randall W. Grimes
  • John K. Leighton
  • Sandra F. Canning
  • Daniel R. Hagen
Part of the Serono Symposia USA book series (SERONOSYMP)

Abstract

The focus of this chapter is the role of the ovarian insulin-like growth factor (IGF) system as an amplification mechanism for FSH action in the ovarian follicle. Recent data from our own laboratory will be emphasized, although numerous investigators have made important contributions to this area. Collectively, these efforts have established the ovarian IGF system as one of the most persuasive and best documented of the putative ovarian paracrine/ autocrine systems. For the purpose of discussion, it is convenient to divide the IGF system into its intracellular transduction mechanism and its extracellular components (Fig. 15.1), each of which is affected by FSH. The current emphasis in our laboratory is on the extracellular components of the IGF system—locally secreted IGFs and their binding proteins—and this emphasis will be reflected in this paper. However, a brief summary of the actions of IGFs on ovarian cells is appropriate.

Keywords

Granulosa Cell Follicular Fluid Porcine Granulosa Cell Deoxyribonucleic Acid Synthesis Porcine Ovary 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • James M. Hammond
  • Judith S. Mondschein
  • Susan E. Samaras
  • Randall W. Grimes
  • John K. Leighton
  • Sandra F. Canning
  • Daniel R. Hagen

There are no affiliations available

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