Regulation of Ovarian Inhibin and Activin Gene Expression by Gonadotropins
Follicle stimulating hormone (FSH) plays a critical role in regulating ovarian function and is a key hormone in initiating follicular recruitment and promoting follicular maturation (1). Additionally, it influences differentiation by modulating steroidogenesis, inducing luteinizing hormone receptors and regulating the synthesis of ovarian hormones, such as inhibin and activin. Inhibin is an important regulator of FSH synthesis and secretion in rats (2), while activin appears to be a paracrine regulator of ovarian function (3, 4) that may also be involved in FSH regulation (5, 6). The study of how these two genes are regulated is important for understanding aspects of the reproductive cycle. This report focuses on the regulation of inhibin and activin gene expression in rat granulosa cells (GC) by gonadotropins.
KeywordsGranulosa Cell Follicle Stimulate Hormone Follicular Fluid Luteinizing Hormone Receptor Chloramphenicol Acetyl Transferase
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