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Diverse Mechanisms Regulating Gene Expression in Granulosa Cells

  • JoAnne S. Richards
  • Richard C. Kurten
  • Susan L. Fitzpatrick
  • Ria B. Oonk
  • Winona L. Wong
Part of the Serono Symposia USA book series (SERONOSYMP)

Abstract

Growth of the ovarian follicle to the preovulatory (PO) stage of development involves specific, sequential changes in the response of granulosa cells to the pituitary gonadotropin, FSH (18, 43, 45). For example, whereas FSH can stimulate mitogenic responses in granulosa cells of small follicles (39), FSH alone (or in combination with steroids) induces expression of specific genes in granulosa cells in large follicles, leading to a highly differentiated state required for ovulation and luteinization (17, 18, 43, 45). Changes in the response of granulosa cells of small and large follicles to FSH are not associated with changes in the number of FSH receptors per cell (42). Rather, follicles acquire enhanced stimulation of adenyl cyclase by FSH (21) and increased responsiveness to the intracellular second messenger, cAMP (43).

Keywords

Granulosa Cell Luteal Cell Large Follicle Aromatase mRNA Aromatase Cytochrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • JoAnne S. Richards
  • Richard C. Kurten
  • Susan L. Fitzpatrick
  • Ria B. Oonk
  • Winona L. Wong

There are no affiliations available

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