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Glycoprotein Hormone Receptors: A Particular Class of G-Protein-Coupled Receptors

  • Rolf Sprengel
  • Thomas Braun
Part of the Serono Symposia USA book series (SERONOSYMP)

Abstract

Molecular cloning and functional expression studies of receptor-encoding cDNAs identified the glycoprotein hormone receptors for lutropin and choriogonadotropin (LH/CG), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) as single polypeptides containing a large putative extracellular domain with 14 leucine-rich repeats and 7 transmembranespanning segments (7 TM)—the hallmark of G-protein-coupled receptors (1–6). Like the G-protein-coupled receptors, the glycoprotein hormone receptors mediate the physiological effect of their hormones via the GS-protein to activate adenyl cyclase in their respective target cells (7, 8). The activation might follow a common mechanism of action characteristic for G-protein-coupled receptors. For many receptors of this kind, the membrane-spanning regions seem to form a binding pocket for the ligand (9). After ligand binding, a conformational change of the receptor molecule might promote its interaction with a G-protein, leading to the activation or inhibition of the signal cascade.

Keywords

Follicle Stimulate Hormone Extracellular Domain Thyroid Stimulate Hormone Hormone Binding Glycoprotein Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Rolf Sprengel
  • Thomas Braun

There are no affiliations available

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