Glycoprotein Hormone Receptors: A Particular Class of G-Protein-Coupled Receptors

  • Rolf Sprengel
  • Thomas Braun
Part of the Serono Symposia USA book series (SERONOSYMP)


Molecular cloning and functional expression studies of receptor-encoding cDNAs identified the glycoprotein hormone receptors for lutropin and choriogonadotropin (LH/CG), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) as single polypeptides containing a large putative extracellular domain with 14 leucine-rich repeats and 7 transmembranespanning segments (7 TM)—the hallmark of G-protein-coupled receptors (1–6). Like the G-protein-coupled receptors, the glycoprotein hormone receptors mediate the physiological effect of their hormones via the GS-protein to activate adenyl cyclase in their respective target cells (7, 8). The activation might follow a common mechanism of action characteristic for G-protein-coupled receptors. For many receptors of this kind, the membrane-spanning regions seem to form a binding pocket for the ligand (9). After ligand binding, a conformational change of the receptor molecule might promote its interaction with a G-protein, leading to the activation or inhibition of the signal cascade.


Follicle Stimulate Hormone Extracellular Domain Thyroid Stimulate Hormone Hormone Binding Glycoprotein Hormone 
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© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Rolf Sprengel
  • Thomas Braun

There are no affiliations available

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