An Overview of FSH Regulation and Action

  • Ulrike Luderer
  • Neena B. Schwartz
Part of the Serono Symposia USA book series (SERONOSYMP)


Follicle stimulating hormone (FSH) and luteinizing hormone (LH) are the two anterior pituitary hormones that control gonadal function. Of the two, LH has been much more extensively studied, due in large part to the earlier development of a sensitive radioimmunoassay (RIA) for LH. Much of what is known about the regulation of FSH synthesis and secretion has been extrapolated from studies of LH. This approach was initially considered valid because both hormones are synthesized and secreted by the same pituitary cells (1, 2) and because a single hypothalamic hormone, gonadotropin releasing hormone (GnRH), has been shown to influence both (3, 4). Despite these important similarities, our understanding of gonadotropin regulation might have been quite different today if we had based it on an equally intensive study of FSH.


Luteinizing Hormone Granulosa Cell Follicle Stimulate Hormone Sertoli Cell GnRH Antagonist 
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Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Ulrike Luderer
  • Neena B. Schwartz

There are no affiliations available

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