Cyanides are a group of organic and inorganic compounds that contain the cyano (CN) group. Free cyanide is defined as the sum of cyanide present as hydrogen cyanide (HCN) and as CN-. The organic cyanides are called nitriles; a few of them dissociate to yield CN- or HCN. In this Health Advisory, only a few widely used industrial inorganic cyanides—hydrogen cyanide (HCN, or prussic acid), sodium cyanide (NaCN), and potassium cyanide (KCN)—are discussed.


Potassium Cyanide Hydrogen Cyanide Cyanide Concentration Sodium Cyanide Free Cyanide 
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  1. ACGIH (1980) American Conference of Governmental Industrial Hygienists. Documentation of the threshold limit values for substances in workroom air, 4th Ed. Supplements through 1981. ACGIH, Cincinnati, OH, pp 109–110.Google Scholar
  2. American Cyanamid Co (1959) Report on sodium cyanide: 30-day repeated feedings to dogs. Central Med Department. Report number 59–14. American Cyanamid, Wayne, NJ.Google Scholar
  3. Ballantyne B, Bright J, Swanston DW, Williams P (1972) Toxicity and distribution of free cyanides given intramuscularly. Med Sci Law 12: 209–219.Google Scholar
  4. Basu TK (1983) High-dose ascorbic acid decreases detoxification of cyanide derived from amygdalin (laetrile): studies in guinea pigs. Can J Physiol Pharmacol 61 (11): 1426–1430.PubMedCrossRefGoogle Scholar
  5. Cullivan BM (1978) Industrial toxics oxidation: an ozone-chlorine comparison. Presented at the 33rd Purdue industrial waste conference. Purdue University, Lafayette, IN.Google Scholar
  6. De Flora S (1981) Study of 106 organic and inorganic compounds in the Salmonella microsome test. Carcinogenesis 2(4): 283–298.Google Scholar
  7. DiPalma JR (ed) (1971) Noxious gases and vapors: I. Carbon monoxide, cyanides, methemoglobin and sulfhemoglobin. In: Drill’s pharmacology in medicine. McGraw-Hill Book Co, New York, NY, pp 1189–1205.Google Scholar
  8. Doherty PA, Ferm VH, Smith RP (1982) Congenital malformations induced by infusion of sodium cyanide in the golden hamster. Toxicol Appl Pharmacol 64: 456–464.PubMedCrossRefGoogle Scholar
  9. Farooqui MYH, Ahmed AE (1982) Molecular interaction of acrylonitrile and potassium cyanide with rat blood. Chem Biol Interact 38: 145–159.PubMedCrossRefGoogle Scholar
  10. Ferguson HC (1962) Dilution of dose and acute oral toxicity. Toxicol Appl Pharmacol 4: 759–762.PubMedCrossRefGoogle Scholar
  11. Gaines TB (1969) Acute toxicity of pesticides. Toxicol Appl Pharmacol 14: 515–534.PubMedCrossRefGoogle Scholar
  12. Gettler AO, Baine JO (1938) The toxicology of cyanide. Am J Med Sci 195: 182–198.CrossRefGoogle Scholar
  13. Gott RD (1978) Development of waste water treatment at the Climax Mine. Mining Cong J 64 (4): 28–34.Google Scholar
  14. Hayes WT (1967) The 90-dose LDso and a chronicity factor as measurer of toxicity. Toxicol Appl Pharmacol 11: 327–335.Google Scholar
  15. Hertting G, Kraupp O, Schnetz E, Wieketich S (1960) Untersuchungen uber die Folgen einer chronischen Verabreichung akut toxischer Dosen von Natriumcyanid an Hunden. Acta Pharmacol Toxicol 17: 27–43.CrossRefGoogle Scholar
  16. Howard JW, Hanzal RF (1955) Chronic toxicity for rats of food treated with hydrogen cyanide. J Agric Food Chem 3: 325–329.CrossRefGoogle Scholar
  17. Isom GE, Burrows GE, Way JL (1982) Effect of oxygen on the antagonism of cyanide intoxication-cytochrome oxidase, in vivo. Toxicol Appl Pharmacol 65(2): 250–256.PubMedCrossRefGoogle Scholar
  18. Karube I, Matsunaga T, Nakahara T, Suzuki S, Kata T (1981) Preliminary screening of mutagens with a microbial sensor. Anal Chem 53(7): 1024–1026.CrossRefGoogle Scholar
  19. Kreutler PA, Varbanov V, Goodman W, Olaya G, Stanbury JB (1978) Interactions of protein deficiency, cyanide and thiocyanate on thyroid function in neonatal and adult rats. Am J Clin Nutr 31: 282–289.PubMedGoogle Scholar
  20. Kruszyna R, Kruszyna H, Smith RP (1982) Comparison of hydroxylamine, 4-dimethylaminophenol and nitrite protection against cyanide poisoning in mice. Arch Toxicol 49: 191–202.PubMedCrossRefGoogle Scholar
  21. Kushi A, Matsumoto T, Yoshida D (1983) Mutagen from the gaseous phase of protein pyrolyzate. Agric Biol Chem 47(9): 1979–1982.CrossRefGoogle Scholar
  22. Liebowitz D, Schwartz H (1948) Cyanide poisoning: report of a case with recovery. Am J Clin Pathol 18: 965–970.PubMedGoogle Scholar
  23. Makene WJ, Wilson J (1972) Biochemical studies in Tanzanian patients with ataxic tropical neuropathy. J Neurol Neurosurg Psych 35: 31–33.CrossRefGoogle Scholar
  24. McCabe LJ, Symons JM, Lee RD, Robeck GG (1970) Survey of community water supply systems. J Am Waterworks Assoc 62: 670–687.Google Scholar
  25. Moore FL (1976) An improved ion exchange resin method for removal and recovery of zinc cyanide and cyanide from electroplating wastes. J Environ Sci Hlth 7: 459–467.CrossRefGoogle Scholar
  26. NIOSH (1976) National Institute for Occupational Safety and Health. Criteria for a recommended standard… occupational exposure to hydrogen cyanide and cyanide salts [NaCN, KCN, and Ca(CN)2]. NIOSH Publication no. 77–108. Department of Health, Education and Welfare (DHEW), U.S. Government Printing Office, Washington, DC.Google Scholar
  27. OSHA (1981) Occupational Safety and Health Administration. General Industry OSHA Safety and Health Standards (29 CFR 1910 ). OSHA Publication no. 2206. U.S. Department of Labor, Washington, DC.Google Scholar
  28. Osuntokun BO, Monekosso GL, Wilson J (1969) Relationship of a degenerative tropical neuropathy to diet, report of a field study. Brit Med J 1: 547–550.PubMedCrossRefGoogle Scholar
  29. Palmer IS, Olson OE (1979) Partial prevention by cyanide of selenium poisoning in rats. Biochem Biophys Res Commun 90(4): 1379–1386.PubMedCrossRefGoogle Scholar
  30. Philbrick DJ, Hopkins JB, Hill DC, Alexander JC, Thomson RG (1979) Effects of prolonged cyanide and thiocyanate feeding in rats. J Toxicol Environ Hlth 5: 579–592.CrossRefGoogle Scholar
  31. Rosehart RG (1973) Mine water purification by reverse osmosis. Can J Chem Eng 51(12): 788–789.CrossRefGoogle Scholar
  32. Sheehy M, Way JL (1968) Effect of oxygen on cyanide intoxication. III. Mithridate. J Pharmacol Exp Therap 161: 163–168.Google Scholar
  33. Smith R, Siebert MS, Hattingh WHJ (1980) Removal of inorganic pollutants from waste water during reclamation for potable reuse. Water South Africa 6(2): 92–95.Google Scholar
  34. Tewe OO, Maner JH (1981a) Performance and pathophysiological changes in pregnant pigs fed cassava diets containing different levels of cyanide. Res Vet Sci 30 (2): 147–151.PubMedGoogle Scholar
  35. Tewe OO, Maner JH (198lb) Long-term and carry-over effect of dietary inorganic cyanide (KCN) in the life cycle performance and metabolism of rats. Toxicol Appl Pharmacol 58 (1): 1–7.CrossRefGoogle Scholar
  36. Towill LE, Arury JS, Whitfield BL, Lewis EB, Galyan EL, Hammone AS (1978) Reviews of the environmental fate of pollutants: V. Cyanide. USEPA report no. EPA–600/1–78–027. NTIS publication no. PB 289920. USEPA Health Effects Research Laboratory, Office of Research and Development (ORD), Cincinnati, OH.Google Scholar
  37. Trachtenberg JJ, Murphy MA (1979) Removal of iron cyanide complexes from waste water utilizing an ion exchange process. Light Metals J 2: 861–870.Google Scholar
  38. USEPA (1979) Method 335.2. Titrimetric; spectrophotometric. In: Methods for chemical analysis of water and wastes. Report no. EPA–600/4–79–020. March 1979. USEPA Environmental Monitoring and Support Laboratory, Cincinnati, OH.Google Scholar
  39. USEPA (1982) Ambient water quality criteria for cyanides, with errata for ambient water quality criteria documents dated June 9, 1981 (updated February 23, 1982 ). NTIS publication no. PB 81–117483. USEPA Environmental Criteria and Assessment Office (ECAO), Cincinnati, OH.Google Scholar
  40. USEPA (1985) Health effects criteria document for cyanide. USEPA Office of Drinking Water, Washington, DC.Google Scholar
  41. USEPA (1986) Final guidelines for carcinogen risk assessment. Fed Regis 51(185): 33992–34003. September 24, 1986.Google Scholar
  42. USPHS (1962) U.S Public Health Service. Drinking water standards. Public Health Service (PHS) Publication no. 956. U.S. Government Printing Office, Washington, DC.Google Scholar
  43. Weast RC (ed) (1980) CRC handbook of chemistry and physics. 61st Ed. CRC Press Inc, Boca Raton, FL. pp B-98, B-133, B-147.Google Scholar
  44. Weiss G (ed) (1986) Hazardous chemical’s Data Book, 2nd Ed. Noyes Data Corporation, Park Ridge, NJ. p 572.Google Scholar
  45. Wood JL, Cooley SL (1956) Detoxication of cyanide by cystine. J Biol Chem 218: 449–457.PubMedGoogle Scholar
  46. Yamamoto K, Yamamoto Y, Hattori H, Samori T (1982) Effects of routes of administration on the cyanide concentration distribution in the various organs of cyanide-intoxicated rats. Tohoku J Exp Med 131: 73–78.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • George W. Ware
    • 1
  1. 1.College of AgricultureUniversity of ArizonaTucsonUSA

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