Vinyl Chloride

  • George W. Ware
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 107)


Vinyl chloride is also known as monochloroethylene and chloroethene. Polyvinyl chloride (PVC) is a polymer of vinyl chloride. Vinyl chloride and PVC are used as raw materials in the plastics, rubber, paper, glass, and automotive industries. They are also used in the manufacture of electrical wire insulation and cables, piping, industrial and household equipment, medical supplies, food packaging materials, and building and construction products. Vinyl chloride copolymers and PVC are distributed and processed in a variety of forms, including dry resins, plastisol (dispersions in plasticizers), organosol (dispersions in plasticizers and volatile solvent), and latex (a colloidal dispersion in water used to coat paper, fabric, or leather) (USEPA 1985a). Its structure and properties are presented in Table 1.


Vinyl Chloride Inhalation Exposure Threshold Limit Value Vinyl Chloride Monomer Governmental Industrial Hygienist 
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  1. ACGIH (1982) American Conference of Governmental Industrial Hygienists. TLV’s —Threshold limit values for chemical substances and physical agents in the workroom environment. ACGIH, Cincinnati, OH.Google Scholar
  2. Amoore JE, Hautala E (1983) Odor as an aid to chemical safety: Odor thresholds compared with threshold limit values and volatilities for 214 industrial chemicals in air and water dilution. J Appl Toxicol 3: 272–290.PubMedCrossRefGoogle Scholar
  3. Anderson D, Hodge MCE, Purchase IFH (1976) Vinyl chloride: dominant lethal studies in male CD-1 mice. Mutat Res 40: 359–370.PubMedCrossRefGoogle Scholar
  4. Bartsch H, Malaveille C, Montesano R (1975) Human, rat and mouse liver-mediated mutagenicity of vinyl chloride in S. typhimurium strains. Int J Cancer 15: 429–437.PubMedCrossRefGoogle Scholar
  5. Bartsch H, Montesano R (1975) Mutagenic and carcinogenic effects of vinyl chloride. Mutat Res 32: 93–114.PubMedGoogle Scholar
  6. Bolt HM, Kappus H, Buchter A, Bolt W (1976) Disposition of (1,2,-1 4C) vinyl chloride in the rat. Arch Toxicol 35: 153–162.PubMedCrossRefGoogle Scholar
  7. Bolt HM, Laib RJ, Kappus H, Buchter A (1977) Pharmacokinetics of vinyl chloride in the rat. Toxicology 7: 179–188.PubMedCrossRefGoogle Scholar
  8. Creech JL, Johnson MN (1974) Angiosarcoma of the liver in the manufacture of polyvinyl chloride. J Occup Med 20: 338–340.Google Scholar
  9. Ducatman A, Hirschhorn K, Selikoff IJ (1975) Vinyl chloride exposure and human chromosome aberrations. Mutat Res 31: 163–168.PubMedGoogle Scholar
  10. Duprat P, Fabry JP, Gradiski D, Magadur JL (1977) Metabolic approach to industrial poisoning: blood kinetics and distribution of 14C-vinyl chloride monomer (V.C.M.). Acta Pharmacol Toxicol Suppl (Kbh) 41 (1): 142–143.Google Scholar
  11. Edmonds LD, Falk H, Nissim JE (1975) Congenital malformations and vinyl chloride. Lancet 2: 1098.Google Scholar
  12. ESEα (1984) Environmental Science and Engineering. Technologies and costs for the removal of volatile organic chemicals from potable water supplies. (Draft) ESE No. 84–912–0300. Prepared for USEPA Science and Technology Branch, Criteria and Standards Division (CSD), Office of Drinking Water, Washington, DC.Google Scholar
  13. Feron VJ, Speek AJ, Williams MI, van Battum D, de Groot AF (1975) Observations on the oral administration and toxicity of vinyl chloride in rats. Food Cosmet Toxicol 13: 633–638.PubMedCrossRefGoogle Scholar
  14. Feron VJ, Hendrikson CFM, Speek AJ, Til HP, Spit BJ (1981) Lifespan oral toxicity study of vinyl chloride in rats. Food Cosmet Toxicol 19: 317–331.PubMedCrossRefGoogle Scholar
  15. Greim H, Bonse G, Radwan Z, Reichert D, Henschler D (1975) Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxirane formation. Biochem Pharmacol 24: 2013–2017.PubMedCrossRefGoogle Scholar
  16. Hatch M, Kline J, Stain Z (1981) Power considerations in studies of reproductive effects of vinyl chloride and some structural analogs. Environ Hlth Perspec 41: 195–201.CrossRefGoogle Scholar
  17. Hefner RE Jr, Watanabe PG, Gehring PJ (1975) Preliminary studies on the fate of inhaled vinyl chloride monomer in rats. Ann NY Acad Sci 246: 135–148.CrossRefGoogle Scholar
  18. Huberman E, Bartsch H, Sachs L (1975) Mutation induction in Chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2-chloroacetaldehyde. Int J Cancer 16: 369–644.CrossRefGoogle Scholar
  19. IARC (1979) International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risk of chemicals to man. Vol 19, pp 377–438. IARC, Lyon, France.Google Scholar
  20. Infante PF, Wagoner JK, Waxweiler RJ (1976a) Carcinogenic, mutagenic, and teratogenic risks associated with vinyl chloride. Mutat Res 41: 131–142.PubMedCrossRefGoogle Scholar
  21. Infante PF, Wagoner JK, Waxweiler RJ, McMichael AJ, Falk H (1976b) Genetic risks of vinyl chloride. Lancet 1: 734–735.PubMedCrossRefGoogle Scholar
  22. John JA, Smith FA, Leong BKJ, Schwetz BA (1977) The effects of maternally inhaled vinyl chloride on embryonal and fetal development in mice, rats and rabbits. Toxicol Appl Pharmacol 39: 497–513.PubMedCrossRefGoogle Scholar
  23. Killian DJ, Picciano DJ, Jacobson CB (1975) Industrial monitonng: A cytogenetic approach. Ann NY Acad Sci 269: 4–11.Google Scholar
  24. Laib RJ, Bolt HM (1977) Alkylation of RNA by vinyl chloride metabolites in vitro and in vivo: Formation of 1-N’-etheno-adenosine. Toxicology 8: 185–195.PubMedCrossRefGoogle Scholar
  25. Lee CC, Bhandari JC, Winston JM, House WB, Dixon RL, Woods JS (1977) Inhalation toxicity of vinyl chloride and vinylidene chloride. Environ Hlth Perspect 21: 25–32.Google Scholar
  26. Lee CC, Bhandari JC, Winston JM, House WB, Dixon RL, Woods JS (1978) Carcinogenicity of vinyl chloride and vinylidene chloride. J Toxicol Environ Hlth 4: 15–30.CrossRefGoogle Scholar
  27. Lilis R, Anderson H, Nicolson WJ, Daum S, Fischbein AS, Selikoff IJ (1975) Prevalence of disease among vinyl chloride and polyvinyl chlonde workers. Ann NY Acad Sci 246: 22–41.PubMedCrossRefGoogle Scholar
  28. Loprieno N, Barale R, Baroncelli S, Bartsch H, Bronzetti G, Cammellini A, Corsi C, Frezza D, Nieri R, Leporini D, Rosellini D, Rossi AM (1977) Induction of gene mutations and gene conversions by vinyl chloride metabolites in yeast. Cancer Res 253–257.Google Scholar
  29. Maltoni C, Lefemine G, Ciliberti A, Cotti G, Carretti D (1981) Carcinogenicity bioassays of vinyl chloride monomer: a model of risk assessment on an experimental basis. Environ Hlth Perspec 41: 3–31.CrossRefGoogle Scholar
  30. Mancuso TF (1975) Comments for opening of discussion on “neoplastic effects.” Ann NY Acad Sci 246: 251–254.PubMedGoogle Scholar
  31. Marsteller HJ, Lelbach WK, Muller R, Gedigk P (1975) Unusual splenomegalic liver disease as evidenced by peritoneoscopy and guided liver biopsy among polyvinyl chloride production workers. Ann NY Acad Sci 246: 95–134.PubMedCrossRefGoogle Scholar
  32. Miller A, Tiersten AS, Chuang M, Selikoff IJ, Warshaw R (1975) Changes in pulmonary function in workers exposed to vinyl chloride and polyvinyl chloride. Ann NY Acad Sci 246: 42–52.PubMedCrossRefGoogle Scholar
  33. Miltner Rα (1984) Personal communication. Cited in: Technologies and costs for the removal of volatile organic chemicals from potable water supplies by environmental science and engineering. USEPA Technical Support Division of Office of Drinking Water (ODW), Cincinnati, OH.Google Scholar
  34. NAS (1977) National Academy of Sciences. Drinking water and health, Vol 1. National Academy Press, Washington, DC. pp. 783–787.Google Scholar
  35. OSHA (1974) Vinyl chloride: exposure standards. Fed Regis 39: 3589.Google Scholar
  36. Parsons F, Wood PR, DeMarco J (1984) Transformation of tetrachloroethene and trichloroethene in microcosms and groundwater, J Am Waterworks Assoc 26 (2): 56f.Google Scholar
  37. Picciano DJ, Flake RE, Gay PC, Killian DJ (1977) Vinyl chloride cytogenetics. J Occup Med 19: 527–530.PubMedGoogle Scholar
  38. Purchase IFH, Richardson CR, Anderson D (1975) Chromosomal and dominant lethal effects of vinyl chloride. Lancet 2 (7931): 410–411.PubMedCrossRefGoogle Scholar
  39. Radike M et al. (1977) Transplacental effects of vinyl chloride in rats. Annual report, pp 183–185. USPHS-ES-00159. Center for Study of the Human Environment, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH.Google Scholar
  40. Selikoff IJ, Hammond EC (eds) (1975) Toxicity of vinyl chloride-polyvinyl chloride. Ann NY Acad Sci, Vol 246.Google Scholar
  41. Suciu I, Prodan L, Ilea E, Paduracu A, Pascu L (1975) Clinical manifestations in vinyl chloride poisoning. Ann NY Acad Sci 246: 53–69.PubMedCrossRefGoogle Scholar
  42. Symons JMα (1978) Interim treatment guide for controlling organic contaminants in drinking water using granular activated carbon. USEPA Office of Research and Development (ORD), Municipal Environmental Research Laboratory, Cincinnati, OH. Cited in USEPA SNARL Document for vinyl chloride (draft) and in USEPA, May 1983, Treatment of volatile organic compounds in drinking water. Report no. EPA–600/8–83–019, Office of Research and Development, Municipal Environmental Research Laboratory, Drinking Water Research Division, Cincinnati, OH.Google Scholar
  43. Til HP, Immel HR, Feron VJα (1983) Lifespan oral carcinogenicity study of vinyl chloride in rats. Final report. Civo Institutes TNO. Report no. V 83.285/291099. Submitted to USEPA Office of Drinking Water, Washington, DC.Google Scholar
  44. Torkelson RR, Oyen F, Rowe VK (1961) The toxicity of vinyl chloride as determined by repeated exposure of laboratory animals. Am Ind Hyg Assoc J 22: 354–361.CrossRefGoogle Scholar
  45. USEPAα (1979) Water related environmental fate of 129 priority pollutants. Report no. EPA–440/4–79–029. USEPA Office of Water Planning and Standards, Washington, DC.Google Scholar
  46. USEPAα (1980a) Vinyl chloride occurrence in drinking water, food, and air. USEPA Office of Drinking Water, Washington, DC.Google Scholar
  47. USEPAα (1980b) Ambient water quality criteria for vinyl chloride. Report no. EPA–440/5–80–078. USEPA Office of Water Regulations and Standards, Washington, DC.Google Scholar
  48. USEPAα (1982) The ground-water supply survey—Summary of volatile organic contaminant occurrence data. USEPA Office of Drinking Water, Technical Support Division, Cincinnati, OH. June.Google Scholar
  49. USEPAα (1985a) Final draft for the dnnking water criteria document on vinyl chloride. TR-540–162. USEPA Office of Drinking Water, Washington DC.Google Scholar
  50. USEPAα (1985b) National primary drinking water regulations; Volatile synthetic organic chemicals, Final rule and proposed rule. Fed Regis 50 (219):46880–933. November 13.Google Scholar
  51. USEPAα (1985c) Method 502.1. Volatile halogenated organic compounds in water by purge-and-trap gas chromatography. USEPA Environmental Monitoring and Support Laboratory, Cincinnati, OH. June 1985.Google Scholar
  52. USEPAα (1985d) Method 524.1. Volatile organic compounds in water by gas chromatography/mass spectrometry. USEPA Environmental Monitoring and Support Laboratory, Cincinnati, OH. June 1985.Google Scholar
  53. USEPAα (1986) Guidelines for carcinogenic risk assessment. Fed Regis 51 (185): 33993–34003. September 24.Google Scholar
  54. USEPAα (1987). National primary drinking water regulations; Synthetic organic chemicals; Monitoring for unregulated contaminants; Final rule. Fed Regis 52 (130):25690–25717. July 8.Google Scholar
  55. USITC (1983) U.S. International Trade Commission. Synthetic organic chemicals, United States production, 1982. USITC publication 1422. USITC, Washington, DC.Google Scholar
  56. Verburgt FG, Vogel E (1977) Vinyl chloride mutagenesis in Drosophila melanogaster. Mutat Res 48: 327–33.PubMedCrossRefGoogle Scholar
  57. Vogel T, McCarty P (1985) Biotransformation of tetrachloroethylene to trichloroethylene, dichloroethylene, vinyl chloride, and carbon dioxide under methanogenic conditions. Appl Environ Microbiol 49 (5): 1080–83.PubMedGoogle Scholar
  58. Watanabe PG, McGowan GR, Gehring PJ (l976a) Fate of [14C]-vinyl chloride after single oral administration in rats. Toxicol Appl Pharmacol 36: 339–52.Google Scholar
  59. Watanabe PG, McGowan GR, Madrid EO, Gehring PJ (1976b) Fate of [14C]-vinyl chloride following inhalation exposure in rats. Toxicol Appl Pharmacol 37: 49–59.PubMedCrossRefGoogle Scholar
  60. Withey JR (1976) Pharmacodynamics and uptake of vinyl chloride monomer administered by various routes to rats. J Toxicol Environ Hlth 1: 381–94.CrossRefGoogle Scholar
  61. Withey JR, Collins BT (1976) A statistical assessment of the quantitative uptake of vinyl chloride monomer from aqueous solution. J Toxicol Environ Hlth 2: 311–21.CrossRefGoogle Scholar
  62. Wood PR, DeMarco J (1980) Effectiveness of various adsorbents in removing organic compounds from water. 1. Removing purgeable halogenated organics. In: McGuire MJ, Suffet IH (eds) Activated carbon adsorption of organics from the aqueous phase, Vol 2. Ann Arbor Science, Ann Arbor, MI. pp 85–114.Google Scholar

Copyright information

© Springer-Verlag New York Inc 1988

Authors and Affiliations

  • George W. Ware
    • 1
  1. 1.College of AgricultureUniversity of ArizonaTucsonUSA

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