Acute Non-A, Non-B Hepatitis: The Pathologist’s Perspective

  • Zachary D. Goodman


The pathologist takes a somewhat different view of viral hepatitis than does the clinician. The pathologic view is colored by the circumstances in which tissue is obtained for examination. This in turn is often dictated by the clinical indications for biopsy with a relative increase in either atypical or chronic cases, or both, and it is also skewed toward the more severe cases seen at autopsy. The spectrum of such cases is illustrated by the consultations seen at the Armed Forces Institute of Pathology (AFIP). The Hepatic Department of the AFIP reviewed 119 cases, both biopsy and autopsy, during 1986 in which the likelihood of non-A, non-B (NANB) hepatitis was raised by the clinical circumstances (Table I). These were nearly all diagnoses of exclusion in which the morphologic patterns were consistent with viral hepatitis, the serologic studies excluded hepatitis A and B, and no drug likely to cause a hepatitis-like injury could be implicated. Of these cases, 23% showed an acute injury, with 15 cases (13%) of acute hepatitis and 12 cases (10%) of massive or submassive necrosis.


Primary Biliary Cirrhosis Acute Hepatitis Bile Duct Injury Fulminant Hepatitis Acute Viral Hepatitis 


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Zachary D. Goodman
    • 1
  1. 1.Department of Hepatic PathologyArmed Forces Institute of PathologyUSA

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