Acute and Chronic Hepatitis B

  • Raymond S. Koff


Acute hepatitis S is a systemic infection in which the liver is the predominant, if not necessarily the sole, target organ of the infectious agent, the hepatitis S virus (HBV). Regardless of whether extrahepatic tissues participate in the replication of this DNA virus, the liver is the principal organ site of the host response to HBV infection. Infection by HBV, one of at least six agents responsible for the disorder known as viral hepatitis, produces a broad spectrum of acute and chronic illness with a wide array of outcomes. In acute hepatitis S infection, this ranges between asymptomatic anicteric self-limited infections at one end and fulminant fatal hepatitis at the opposite end. When HBV infection is persistent, the spectrum of disease also varies strikingly between an asymptomatic HBV carrier state at one extreme and progressive chronic hepatitis S with or without the development of cirrhosis or primary hepatocellular carcinoma at the other.


HBeAg Seroconversion HBsAg Carrier Duck Hepatitis Chronic Lobular Hepatitis Fulminant Fatal Hepatitis 
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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Raymond S. Koff
    • 1
    • 2
  1. 1.Department of MedicineFramingham Union HospitalFraminghamUSA
  2. 2.Hepatology SectionBoston University School of MedicineBostonUSA

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