Hemochromatosis: Pathology

  • Peter J. Scheuer


Iron overload in tissues, including the liver, can be designated as siderosis. This may be transient as in temporary post-transfusion overload, static as in a site of old hemorrhage, or progressive as in hemochromatosis. The amount of iron in hepatocytes can be roughly graded by visual assessment into grades 0–4. The relationship between histologic grade and iron content is not linear, grades 1 and 2 representing relatively small amounts, and grades 3 and 4 substantial increase.1 Image analysis offers the possibility of more precise evaluation.2


Iron Overload Prussian Blue Portal Tract Liver Iron Liver Iron Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Barry M: Liver iron concentration, stainable iron, and total body storage iron. Gut 15:411–415, 1974.PubMedCrossRefGoogle Scholar
  2. 2.
    Deugnier Y, Margules S, Brissot P, et al: Comparative study between biochemical and histological methods and image analysis in liver iron overload. J Clin Pathol 35:45–51, 1982.PubMedCrossRefGoogle Scholar
  3. 3.
    Weir MP, Sharp GA, Peters TJ: Electron microscopic studies of human haemosiderin and ferritin. J Clin Pathol 38:915–918, 1985.PubMedCrossRefGoogle Scholar
  4. 4.
    Gollan JL: Diagnosis of hemochromatosis. Gastroenterology 84:418–431, 1983.PubMedGoogle Scholar
  5. 5.
    Bassett ML, Halliday JW, Powell LW: Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 6:24–29, 1986.PubMedCrossRefGoogle Scholar
  6. 6.
    Peters TJ, Seymour CA: Acid hydrolase activities and lysosomal integrity in liver biopsies from patients with iron overload. Clin Sci Mol Med 50:75–78, 1976.PubMedGoogle Scholar
  7. 7.
    Bacon BR, Tavill AS, Brittenham GM, et al: Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J Clin Invest 71:429–439, 1983.PubMedCrossRefGoogle Scholar
  8. 8.
    Tavill AS, Bacon BR. Hemochromatosis: How much iron is too muchS Hepatology 6:142–145, 1986.PubMedCrossRefGoogle Scholar
  9. 9.
    Niederau C, Fischer R, Sonnenberg A, et al: Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. S Engl J Med 313:1256–1262, 1985.CrossRefGoogle Scholar
  10. 10.
    LeSage GD, Baldus WP, Fairbanks VF, et al: Hemochromatosis: Genetic or alcohol-inducedS Gastroenterology 84:1471–1477, 1983.PubMedGoogle Scholar
  11. 11.
    Jakobovits AW, Morgan MY, Sherlock S: Hepatic siderosis in alcoholics. Dig Dis Sci 24:305–310, 1979.PubMedCrossRefGoogle Scholar
  12. 12.
    Kent G, Popper H: Liver biopsy in diagnosis of hemochromatosis. Am J Med 44:837–841, 1968.PubMedCrossRefGoogle Scholar
  13. 13.
    Jean G, Terzoli S, Mauri R, et al: Cirrhosis associated with multiple transfusions in thalassaemia. Arch Dis Child 59:67–70, 1984.PubMedCrossRefGoogle Scholar
  14. 14.
    Moroni GA, Piacentini G, Terzoli S, et al: Hepatitis S or non-S, non-B virus infection in multitransfused thalassaemic patients. Arch Dis Child 59:1127–1130, 1984.PubMedCrossRefGoogle Scholar
  15. 15.
    Masera G, Jean G. Conter V, et al: Sequential study of liver biopsy in thalassaemia. Arch Dis Child 55:800–802, 1980.PubMedCrossRefGoogle Scholar
  16. 16.
    Aldouri MA, Wonke B, Hoffbrand AV, et al: Iron state and hepatic disease in patients with thalassaemia major, treated with long term subcutaneous desferoxamine. J. Clin Pathol 40:1353–1359, 1987.PubMedCrossRefGoogle Scholar
  17. 17.
    Blisard KS, Bartow SA: Neonatal hemochromatosis. Hum Pathol 17:376–383, 1986.PubMedCrossRefGoogle Scholar
  18. 18.
    Hengeveld P, Zuyderhoudt FMJ, Jöbsis AC, van Gool J: Some aspects of iron metabolism during acute viral hepatitis. Hepatogastroenterology 29:138–141, 1982.PubMedGoogle Scholar
  19. 19.
    Bardadin KA, Scheuer PJ: Endothelial cell changes in acute hepatitis. A light and electron microscopic study. J Pathol 144:213–220, 1984.PubMedCrossRefGoogle Scholar
  20. 20.
    Cortés JM, Oliva H, Paradinas FJ, Hernadez-Guío C: The pathology of the liver in porphyria cutanea tarda. Histopathology 4:471–485, 1980.PubMedCrossRefGoogle Scholar
  21. 21.
    Lefkowitch JH, Grossman ME: Hepatic pathology in porphyria cutanea tarda. Liver 3:19–29, 1983.PubMedGoogle Scholar
  22. 22.
    Rao KV, Anderson WR: Hemosiderosis: An unrecognized complication in renal allograft recipients. Transplantation 33:115–117, 1982.PubMedCrossRefGoogle Scholar
  23. 23.
    Rao KV, Anderson WR: Hemosiderosis and hemochomatosis in renal transplant recipients. Am J Nephrol 5:419–430, 1985.PubMedCrossRefGoogle Scholar
  24. 24.
    Anderson WR, Rao KV: Hepatic iron overload in renal transplant recipients: Ultrastructural observations. Ultrastruct Pathol 10:227–234, 1986.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Peter J. Scheuer
    • 1
  1. 1.Royal Free Hospital and School of MedicineLondonEngland

Personalised recommendations