α1-Antitrypsin Deficiency and Neonatal Cholestasis

  • William F. Balistreri
  • J. Thomas Stocker


Neonatal cholestasis, in its broadest definition, i. e., prolonged conjugated hyperbilirubinemia, regardless of the site of injury, offers an interesting exercise in differential diagnosis. There are multiple areas of overlap between discrete and apparently disparate disease categories. A simple conceptual approach is to categorize neonates presenting with cholestasis into those with predominant extrahepatic disease and those with predominant intrahepatic disease (Fig. 1).


Biliary Atresia Choledochal Cyst Intrahepatic Cholestasis Alagille Syndrome Cryptogenic Cirrhosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • William F. Balistreri
    • 1
  • J. Thomas Stocker
    • 2
  1. 1.Division of Pediatric Gastroenterology and NutritionChildren’s Hospital Medical CenterCincinnatiUSA
  2. 2.Armed Forces Institute of PathologyUSA

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