Chronic Drug-Induced Hepatotoxicity: Clinical Aspects
It is a special privilege to contribute a discussion of one aspect of drug hepatotoxicity that is well recognized as having been a major interest of Dr. Zimmerman for much of his professional life. Dr. Zimmerman suspected, and argued without much early success, in favor of the primacy of biochemical events in mediating certain forms of drug hepatotoxicity at a time when the prevailing wisdom focused on the importance of (largely unsubstantiated) immune mechanisms. While observations over the past decade have generally supported Dr. Zimmerman’s views, the area of chronic drug-induced hepatotoxicity is one in which supporting data for the role of biochemical events in mediating such injury remain elusive.
KeywordsPrimary Biliary Cirrhosis Chronic Active Hepatitis Alcoholic Hepatitis Porphyria Cutanea Tarda Drug Hepatotoxicity
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