Portal Hypertension in Alcoholic Cirrhosis

  • Roberto J. Groszmann
  • Colin E. Atterbury


Chronic progressive liver disease of various etiologies evolves into a final common pathway of circulatory and metabolic complications that eventually become the dominant aspects of the disease. Although the metabolic complications are themselves extensive, and in many cases life-threatening, the circulatory-related events are the most dramatic and the ones most likely to reflect the severity of the underlying liver disease. In fact, many of the metabolic abnormalities observed in chronic liver disease are initiated by a hemodynamic event: portal blood bypasses the liver through extrahepatic and intrahepatic shunts or through hepatic sinusoids that have decreased permeability both to essential nutrients and to toxins that require metabolism by the hepatocytes.1, 2


Portal Hypertension Portal Pressure Transmural Pressure Alcoholic Cirrhosis Portal Blood Flow 


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Roberto J. Groszmann
    • 1
    • 2
  • Colin E. Atterbury
    • 1
    • 2
  1. 1.The Liver Center, Department of Internal MedicineYale University School of MedicineNew HavenUSA
  2. 2.Hepatic Hemodynamic LaboratoryVeterans Administration Medical CenterWest HavenUSA

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