Antigen-Specific Stimulation of Human Autoreactive B Lymphocytes
The generation of antibody forming cells (AFC) after antigen-specific stimulation of B lymphocytes involves a number of distinct, separately controlled steps. These are transition from G0 to G1 of the cell cycle after binding of antigen to surface immunologlobulin (1) (activation), several cycles of cell division (proliferation) and finally maturation into immunoglobulin secreting cells (2). For these steps, most B cell responses require participation of T cells or T cell-derived lympho-kines which may act in a MHC restricted or MHC non-restricted manner (3,4).
KeywordsAutoimmune Thyroiditis Cell Repertoire Pokeweed Mitogen Antibody Form Cell Efferent Phase
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