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Antigen-Specific Stimulation of Human Autoreactive B Lymphocytes

  • T. Logtenberg
  • A. Kroon
  • F. H. J. Gmelig-Meyling
  • R. E. Ballieux
Part of the NATO ASI Series book series (NSSA, volume 123)

Abstract

The generation of antibody forming cells (AFC) after antigen-specific stimulation of B lymphocytes involves a number of distinct, separately controlled steps. These are transition from G0 to G1 of the cell cycle after binding of antigen to surface immunologlobulin (1) (activation), several cycles of cell division (proliferation) and finally maturation into immunoglobulin secreting cells (2). For these steps, most B cell responses require participation of T cells or T cell-derived lympho-kines which may act in a MHC restricted or MHC non-restricted manner (3,4).

Keywords

Autoimmune Thyroiditis Cell Repertoire Pokeweed Mitogen Antibody Form Cell Efferent Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • T. Logtenberg
    • 1
  • A. Kroon
    • 1
  • F. H. J. Gmelig-Meyling
    • 1
  • R. E. Ballieux
    • 1
  1. 1.Department of Clinical ImmunologyUniversity HospitalUtrechtThe Netherlands

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