Restricted Set of V Genes and Extensive Idiotype Crossreactivity of Autoantibodies
The production of antibodies recognizing self-antigens is one of the hallmarks of autoimmune diseases (1). Despite the obvious role of T cells in the production of autoantibodies and the existence of genetic and environmental factors, the investigation of autoreactive B cell clones may bring important clues in the comprehension of the pathogenesis of auto-immunity. One of the rational approaches is to look for the existence of common features among autoantibodies of various specificities. The existence of similarities could imply that common mechanisms are involved in diseases with different clinical manifestations.
KeywordsImmature Phenotype Antiidiotypic Antibody Cytoplasmic Lysate Immunoglobulin Heavy Chain Variable Monoclonal Rheumatoid Factor
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