Acquired Alterations Around the Cε Gene in Cultured Mouse Myeloma Cells
Our laboratory has focused on the study of various aspects of DNA rearrangements that affect the organization and expression of immunoglobulin heavy chain genes. Using a mouse myeloma cell line, MPC11 (IgG2b/k), we have isolated variants making various types of altered heavy chains, including class switch variants producing γ2a heavy chains, hybrid (γ2b–γ2a) heavy chain producers, and short γ2b heavy chain producers.
KeywordsHeavy Chain Heavy Chain Gene Albert Einstein College Rearrangement Event Immunoglobulin Heavy Chain Gene
Unable to display preview. Download preview PDF.
- 2.Eckhardt, L.A., and B.K. Birshtein, 1985. Independent immunoglobulin class-switch events occurring in a single myeloma cell line. Molec. Cell. Biol. 5:856–868.Google Scholar