Private and Shared Idiotypic Determinants of the Human T Cell Antigen Receptor

  • Robert D. Bigler
  • Nicholas Chiorazzi
Part of the NATO ASI Series book series (NSSA, volume 123)


T lymphocytes play a crucial role in initiating most immune responses. Not only are T cells, especially antigen-specific helper T cells, necessary to induce functional effector T cell subpopulations but also to initiate development of the B cell response. The complete understanding of this co-ordinated T-B response requires knowledge of both the mechanism of T cell activation and the method by which T cells transmit signals to B cells. Once activated, T lymphocytes appear to function by secreting various soluble factors. These factors have been reported to influence B cell proliferation, differentiation, and immunoglobulin isotype selection (1–3). The nature of the initial events in triggering T lymphocytes to progress from a resting to activated state is poorly understood. Understanding the requirements to initiate this specific T cell activation, however, is crucial to understanding the integration of these two major functional arms of the immune system. The recent definition of the T cell antigen receptor using both monoclonal antibodies (mAbs) and cDNA probes has permitted a new, more precise method for investigating both the cellular events and molecular structures involved in this initial stage of T-B interaction.


Cell Antigen Receptor Normal Peripheral Blood Normal Peripheral Blood Mononuclear Cell IDIOTYPIC Determinant Cell Specific Surface Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Howard, M., & Paul, W.E. Ann. Rev. Immunol. 1:307–333 (1983).CrossRefGoogle Scholar
  2. 2.
    Mayer, L.M., Fu, S.M., & Kunkel, H.G. Immunol. Rev. 78:119–135 (1984).CrossRefGoogle Scholar
  3. 3.
    Marrack, P. et al. Immunol. Rev. 63:33–49 (1982).CrossRefGoogle Scholar
  4. 4.
    Binz, H., & Wigzell, H. J. Exp. Med. 142:197–211 (1979).Google Scholar
  5. 5.
    Krammer, P.H., Rehberger, R., & Eichmann, K. J. Exp. Med. 151:1166–1182 (1980).CrossRefGoogle Scholar
  6. 6.
    Rubin, B., Hertel-Wulff, B., & Kiraura, A. J. Exp. Med. 150:307–321 (1979).CrossRefGoogle Scholar
  7. 7.
    Lea, T. et al. J. Immunol. 122:2413–2417 (1979).Google Scholar
  8. 8.
    Eichmann, K. Adv. Immunol. 26:195–254 (1977).CrossRefGoogle Scholar
  9. 9.
    Tokuhisa, T., & Taniguchi, M. J. Exp. Med. 155:126–139 (1982).CrossRefGoogle Scholar
  10. 10.
    Nagy, Z.A. et al. Eur. J. Immunol. 12:393–400 (1982).CrossRefGoogle Scholar
  11. 11.
    Binz, H., & Wigzell, H. J. Exp. Med. 154:1261–1278 (1981).CrossRefGoogle Scholar
  12. 12.
    Rosenstein, R.W. et al. Proc. Natl. Acad. Sci. USA 78:5821–5825 (1981).CrossRefGoogle Scholar
  13. 13.
    Allison, J.P., McIntyre, B.W., & Bloch, D. J. Immunol. 129:2293–2300 (1982).Google Scholar
  14. 14.
    Haskins, K. et al. J. Exp. Med. 157:1149–1169 (1983).CrossRefGoogle Scholar
  15. 15.
    Meuer, S.C. et al. J. Exp. Med. 157:705–719 (1983).CrossRefGoogle Scholar
  16. 16.
    Bigler, R.D. et al. J. Exp. Med. 158:1000–1005 (1983).CrossRefGoogle Scholar
  17. 17.
    Kappler, J.R. et al. Cell 34:727–737 (1983).CrossRefGoogle Scholar
  18. 18.
    Meuer, S.C. et al. Science 222:1239–1241 (1983).CrossRefGoogle Scholar
  19. 19.
    Posnett, D.N. et al. J. Exp. Med. 160:494–505 (1984).CrossRefGoogle Scholar
  20. 20.
    Yanagi, Y.Y. et al. Nature (London) 308:145–149 (1984).CrossRefGoogle Scholar
  21. 21.
    Hedrick, S. et al. Nature (London) 308:149–153 (1984).CrossRefGoogle Scholar
  22. 22.
    Hedrick, S. et al. Nature (London) 308:153–158 (1984).CrossRefGoogle Scholar
  23. 23.
    Acuto, O. et al. Proc. Natl. Acad. Sci. USA 81:3851–3855 (1984).CrossRefGoogle Scholar
  24. 24.
    Chien, Y. et al. Nature (London) 312:33–35 (1984).MathSciNetCrossRefGoogle Scholar
  25. 25.
    Saito, H. et al. Nature (London) 312:36–40 (1984).CrossRefGoogle Scholar
  26. 26.
    Hannum, C.H. et al. Nature (London) 312:65–67 (1984).CrossRefGoogle Scholar
  27. 27.
    Sim, G.K. et al. Nature (London) 312:771–775 (1984).CrossRefGoogle Scholar
  28. 28.
    Chien, Y. et al. Nature (London) 309:322–326 (1984).CrossRefGoogle Scholar
  29. 29.
    Siu, G. et al. Cell 37:393–401 (1984).CrossRefGoogle Scholar
  30. 30.
    Malissen, M. et al. Cell 37:1101–1110 (1984).CrossRefGoogle Scholar
  31. 31.
    Sims, J.E. et al. Nature (London) 312:541–545 (1984).CrossRefGoogle Scholar
  32. 32.
    Duby, A.D. et al. Science 228:1204–1206 (1985).CrossRefGoogle Scholar
  33. 33.
    Hood, L., Kronenberg, M., & Hunkapiller, T. Cell 40:225–229 (1985).CrossRefGoogle Scholar
  34. 34.
    McIntyre, B.W. & Allison, J.P. Cell 34:739–746 (1983).CrossRefGoogle Scholar
  35. 35.
    Brenner, M.B. et al. J. Exp. Med. 160:541–551 (1984).CrossRefGoogle Scholar
  36. 36.
    Haskins, K. et al. J. Exp. Med. 160:452–471 (1984).CrossRefGoogle Scholar
  37. 37.
    Acuto, O. et al. J. Exp. Med. 161:1326–1343 (1985).CrossRefGoogle Scholar
  38. 38.
    Bigler, R.D., Posnett, D.N., & Chiorazzi, N. J. Exp. Med. 161:1450–1463 (1985).CrossRefGoogle Scholar
  39. 39.
    Moretta, A. et al. J. Exp. Med. 162:1393–1398 (1985).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Robert D. Bigler
    • 1
  • Nicholas Chiorazzi
    • 1
  1. 1.The Rockefeller UniversityNew YorkUSA

Personalised recommendations