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The Role of Receptor Immunoglogulin in Antigen-Specific, MHC-Restricted T Cell/B Cell Cooperation

  • David C. Parker
  • Hans-Peter Tony
Part of the NATO ASI Series book series (NSSA, volume 123)

Abstract

Clonal selection theory assigns a central role to membrane Ig in determining the specificity of the antibody response. However, the combination of antigen with membrane Ig is insufficient to induce resting B cell to produce a clone of antibody secreting cells; for the antibody response to soluble protein antigens, the same molecule of antigen needs to be recognized by an antigen-specific helper T cell. We share Howard Grey’s perspective presented earlier that B cells get help by acting as very efficient antigen-presenting cells (APC) for antigens that bind to membrane Ig, and that recognition of the same molecule by B cells and T cells is sequential rather than simultaneous. This scheme (Figure 1) explains MHC-restriction of T cell/B cell cooperation, as well as the ability of T cells, which see processed antigen and tend to cross-react extensively on denatured proteins or peptides, to help B cells make antibodies which can be exquisitely sensitive to protein conformation.

Keywords

Major Histocompatibility Complex Antigen Presentation Major Histocompatibility Complex Allele Bystander Cell Antibody Secreting Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • David C. Parker
    • 1
  • Hans-Peter Tony
    • 1
  1. 1.Department of Molecular Genetics and MicrobiologyUniversity of Massachusetts Medical SchoolWorcesterUSA

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