Control of B Cell Activation by Helper T Cells

  • Kim Bottomly
  • John P. Tite
  • Barry Jones
  • Eileen Becker-Dunn
  • Jonathan Kaye
  • Abraham Kupfer
  • Charles A. JanewayJr.
Part of the NATO ASI Series book series (NSSA, volume 123)


The activation of B cells to secrete antibody by helper T cells (Th) was one of the first cell interactions to be characterized in the immune response.1 The process has been extensively characterized since its initial description twenty years ago. Two features of this cellular interaction have attracted particular attention, the requirement for physical linkage of the determinant recognized by the B cell to the determinant recognized by the helper T cell2 and the requirement for identity in the I region of the major histocompatibility complex (MHC).3 These two features suggested that intimate contact between the helper T cell and the B cell were required for efficient B cell activation. The stringency of these requirements, and the failure to activate ‘bystander’ B cells in in vivo systems, further suggested that a signal might be transmitted to the B cell directly via cell:cell contact, for instance by aggregation of the B cell’s Ia glycoproteins.


Antibody Response Cell Repertoire Howard Hughes Medical Institute Plaque Form Cell Cell Deficient Mouse 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Kim Bottomly
    • 1
  • John P. Tite
    • 1
  • Barry Jones
    • 1
  • Eileen Becker-Dunn
    • 1
  • Jonathan Kaye
    • 1
  • Abraham Kupfer
    • 1
  • Charles A. JanewayJr.
    • 1
  1. 1.Division of Immunology, Department of Pathology, Howard Hughes Medical InstituteYale University School of MedicineNew HavenUSA

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