Application of the Staphylococcus Aureus Bacteria to the Study of Human B Cell Proliferation and Differentiation

  • Sergio Romagnani
Part of the NATO ASI Series book series (NSSA, volume 123)


The ability of several bacteria or bacterial cell products to act as polyclonal B-cell activators (PBAs) is known for many years. Among bacterial PBAs active on human B cells, Staphylococcus aureus Cowan first strain (SAC) and its cell wall component, Staphylococcal protein A (SpA), is undoubtedly the most interesting one. In the first part of of this paper the mechanisms by which SAC bacteria activate human B cells are discussed. In the second part, data obtained by the application of SAC bacteria to the study of events involved in the induction of human B cells from the resting state to immunoglobulin (Ig)-secreting cells are reported.


Bacterial Cell Wall Mitogenic Activity Staphylococcus Aureus Cowan Tonsil Cell Bacterial Cell Product 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Sergio Romagnani
    • 1
  1. 1.Division of Allergology and Clinical Immunology, Policlinico di CareggiUniversity of FlorenceFirenzeItalia

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