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The Role of Proteins in Vesicular Stomatitis Virus RNA Replication

  • Gail W. Wertz
  • Nancy L. Davis
  • John Patton
Part of the The Viruses book series (VIRS)

Abstract

The negative-strand RNA genome of vesicular stomatitis virus (VSV) serves as template for two types of RNA-synthesis reactions, transcription and replication. A major distinction between the two RNA-synthesis processes is a requirement for protein synthesis. Transcription, the synthesis of the leader RNA and five discrete monocistronic messenger RNAs (mRNAs), does not require protein synthesis. Replication, the production of full-length copies of the viral RNA, requires continuous synthesis of viral proteins. This chapter will focus on the question of what newly synthesized protein or proteins are required to effect and maintain the transition from transcription to replication of the negative-strand RNA. Reviews of negative-strand virus RNA replication, including discussions of the nature of the template and specific sequences involved in replication, were presented by Wertz (1980), Lazzarini et al. (1981), and Ball and Wertz (1981). This chapter will concentrate on work that has been carried out since these previous reviews.

Keywords

Vesicular stomatitIs Virus Nucleocapsid Protein Replication System Template Protein Viral Protein Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Gail W. Wertz
    • 1
  • Nancy L. Davis
    • 1
  • John Patton
    • 1
  1. 1.Department of Microbiology and Immunology, School of MedicineThe University of North CarolinaChapel HillUSA

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