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Tobacco Mosaic Virus Antigenic Structure

  • M. H. V. Van Regenmortel
Part of the The Viruses book series (VIRS)

Abstract

When the primary structure of the TMV protein subunit (TMVP) was elucidated more than 25 years ago (Anderer et al., 1960; Tsugita et al.,1960), it became possible for the first time to analyze the antigenicity of a virus at the molecular level (Anderer, 1963a; Benjamini et al., 1964). Two regions of TMVP were singled out for analysis in these early studies: the C-terminal hexapeptide corresponding to residues 153–158 (Anderer, 1963b), and a tryptic peptide corresponding to residues 93–112 (Benjamini et al., 1965; Young et al., 1966). Several years later, TMV also became the first virus to have its three-dimensional structure elucidated by X-ray crystallography (see Chapter 2) and this made it possible to interpret immunochemical data in terms of the known location of each residue. This led to a rapid increase in our knowledge of the antigenic structure of TMV (Milton and Van Regenmortel, 1979; Altschuh et al., 1983, 1985; Al Moudallal et al., 1982, 1985) with the result that the immunochemical properties of TMV are probably better known than those of any other virus.

Keywords

Coat Protein Tobacco Mosaic Virus Tryptic Peptide Complement Fixation Antigenic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • M. H. V. Van Regenmortel
    • 1
  1. 1.Institut de Biologie Moléculaire et Cellulaire du CNRSStrasbourg CédexFrance

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