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Role of Calmodulin in the Regulation of Neuronal Function

  • M. Billingsley
  • I. Hanbauer
  • D. Kuhn

Abstract

Calcium and cyclic nucleotides have long been recognized to act as second messengers operative in the amplification of extracellular signals controlling cellular responses in eucaryotic cells.1 The mode by which the free intracellular Ca2+ concentration is coupled to cellular regulatory mechanisms has been elucidated by the discovery of structurally related proteins that possess high-affinity binding sites for Ca2+.2 Among this group of proteins, only calmodulin (CaM) has a broad distribution within the cell and throughout different tissues and species.3 Moreover, in the nervous system CaM has been found in both pre- and postsynaptic neuronal elements. The ability of CaM to bind Ca2+ and subsequently to interact with a large number of enzymes and proteins has established a pivotal role of this regulatory protein in neuronal function.

Keywords

Tyrosine Hydroxylase Adenylate Cyclase Myelin Basic Protein Cyclic Nucleotide Dependent Protein Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • M. Billingsley
    • 1
  • I. Hanbauer
    • 1
  • D. Kuhn
    • 1
  1. 1.Section on Biochemical PharmacologyNational Heart, Lung, and Blood Institute, National Institutes of HealthBethesdaUSA

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