Thyrotropin-Releasing Hormone

  • Chandan Prasad


Although the hypothalmic control of anterior pituitary function through endogenous chemical substances was postulated more than a generation ago, not until 1955 did the search begin for the hypothalamic release-modulating substances.1 Thyrotropin-releasing hormone (TRH) (Fig. 1) was the first hypothalamic hypophysiotropic hormone to be chemically characterized in the laboratories of Drs. Andrew Schally and Roger Guillemin.2,3 Soon after this discovery, synthetic TRH became available, and TRH radioimmunoassays were developed.4–6 This prompted a great flurry of research activity in various aspects of TRH endocrinology, biochemistry, physiology, and pharmacology. It has become obvious now that thyrotropin (TSH) release from the pituitary is only one of numerous actions of TRH, and this tripeptide has been associated with a large variety of other endocrine and nonendocrine central nervous system-related functions (see Section 4, Tables IV and V).


Pyroglutamic Acid Synaptic Junction Constituent Amino Acid Hypothalamic Content Attenuation Attenuation 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Chandan Prasad
    • 1
  1. 1.Departments of Medicine (Section of Endocrinology) and BiochemistryLouisiana State University Medical CenterNew OrleansUSA

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