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Neurotensin

  • François B. Jolicoeur
  • Francis Rioux
  • Serge St.-Pierre

Abstract

It has now been a decade since neurotensin was first isolated from bovine hypothalami by Carraway and Leeman.1 The peptide was so named because of its presence in neural tissue and its marked hypotensive effect in the rat. Shortly after this, neurotensin was found to be a tridecapeptide having the following amino acid sequence: pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH.2 Later, neurotensin was also detected in the gastrointestinal tract of animals3 and, therefore, is now considered part of a growing list of brain-gut peptides. Since its discovery, neurotensin has attracted considerable experimental attention, and the vast amount of information that has already accumulated on this peptide has been the subject of several reviews4–10 and, recently, the focus of an international symposium.11 In the present chapter, we attempt to summarize the findings on the distribution, metabolism, and actions of neurotensin in the CNS as well as discuss the possible neurophysiological roles of this neuropeptide.

Keywords

Motor Activity Nucleus Accumbens Ventral Tegmental Area York Academy Direct Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • François B. Jolicoeur
    • 1
  • Francis Rioux
    • 2
  • Serge St.-Pierre
    • 2
  1. 1.Department of Psychiatry, Faculty of MedicineUniversity of SherbrookeSherbrookeCanada
  2. 2.Department of Physiology and Pharmacology, Faculty of MedicineUniversity of SherbrookeSherbrookeCanada

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