The Neurochemical Study of Sleep

  • Antonio Giuditta
  • Carla Perrone Capano
  • Gigliola Grassi Zucconi


Knowledge of the complex relationship existing between sleep and brain biochemistry has been accumulating at a relatively slow pace. Progress in this field was thoroughly reviewed approximately 6 years ago,1,2 and there is little evidence that the rate of this progress has accelerated at all since then. Yet, such a goal should be considered an essential endeavor of the neurosciences. Although neurochemical studies cannot be taken as the only methodology leading to the goal, it is becoming increasingly evident that the final sentence of the chapter describing the role of sleep will not be written until we will know the type of operations a sleeping brain is performing at a molecular level. In turn, it is just as obvious that to design rewarding experiments at a molecular level, a general understanding of the biology of sleep is required, and questions should be asked within the framework of available hypotheses on the role of sleep. One should also remember that brain is not the only target organ for the functions of sleep. Other bodily activities are influenced by sleep, as is mental performance.


Cerebral Blood Flow Glia Cell Paradoxical Sleep Supraoptic Nucleus Neurochemical Study 


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Antonio Giuditta
    • 1
    • 2
  • Carla Perrone Capano
    • 1
    • 2
  • Gigliola Grassi Zucconi
    • 3
  1. 1.Institute of General Physiology, Faculty of SciencesUniversity of NaplesItaly
  2. 2.International Institute of Genetics and BiophysicsItaly
  3. 3.Institute of Cell Biology, Faculty of SciencesUniversity of PerugiaPerugiaItaly

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