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Behavioral and Neurochemical Effects of ACTH

  • Willem Hendrik Gispen
  • Henk Zwiers

Abstract

The role that peptide hormones play in the regulation of target cell metabolism is well documented. Numerous results suggest that these hormones are in a similar way important to brain cell metabolism. Focusing on corticotropin (ACTH), it seems reasonable to expect that its neurochemical action somehow underlies its behavioral effects. Thus, a great deal of recent research has dealt with the interrelationship of ACTH, brain metabolism, and behavior. The present chapter aims to summarize some of the results obtained in studies on ACTH, brain, and behavior. In particular, recent progress in studies of healthy, aged, or mentally disabled human beings is discussed to illustrate the potential clinical importance of the peptides derived from ACTH. In the last part of the chapter we review the evidence that ACTH, by affecting events associated with the function of synaptic membranes, may influence ongoing transmission in certain synapses, presumably contributing to its modulatory action on behavior in animal and man.

Keywords

Passive Avoidance Adrenal Cortex Phosphatidic Acid Neural Substrate Opiate Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Willem Hendrik Gispen
    • 1
  • Henk Zwiers
    • 1
  1. 1.Division of Molecular Neurobiology, Rudolf Magnus Institute for Pharmacology, and Institute of Molecular BiologyState University of UtrechtUtrechtThe Netherlands

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