Effects of Gastrointestinal Peptides on the Nervous System

  • Gyula Telegdy


The discovery that some gastrointestinal peptides are present not only in the gastrointestinal tract but also in the central and the peripheral nervous system has made this topic a very exciting one in current neurobiology.


Vasoactive Intestinal Polypeptide Pancreatic Polypeptide Gastric Inhibitory Polypeptide Antral Mucosa Gastrointestinal Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Bayliss, W. M., and Starling, E. H., 1902, J. Physiol. (Lond.) 28:325–335.Google Scholar
  2. 2.
    Jorpes, J. E., and Mutt, V., 1961, Acta Chem. Scand. 15:1790–1791.CrossRefGoogle Scholar
  3. 3.
    Jorpes, J. E., and Mutt, V., 1966, Acta Physiol. Scand. 66:316–325.PubMedCrossRefGoogle Scholar
  4. 4.
    Polak, J. M., Coulling, I., Bloom, S. R., and Pearse, A. G. E., 1973, Scand. J. Gastroenterol. 6:739–744.CrossRefGoogle Scholar
  5. 5.
    O’Donohue, T. L., Charlton, C. G., Miller, R. L., Boden, G., and Jacobowitz, D. M., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:5221–5224.PubMedCrossRefGoogle Scholar
  6. 6.
    Samson, W. K., Lumpkin, M. D., Vijayan, E., and McCann, S. M., 1982, Endocrinol. Exp. 16:177–189.PubMedGoogle Scholar
  7. 7.
    Fuxe, K., Anderson, K., Hökfelt, T., Mutt, V., Ferland, L., Agnati, L. F., Ganten, D., Said, S., Eneroth, P., and Gustafsson, J. A., 1979, Fed. Proc. 38:2333–2340.PubMedGoogle Scholar
  8. 8.
    Phillis, J. W., and Kirkpatrick, J. R., 1980, Can. J. Physiol. Pharmacol. 58:612–623.PubMedCrossRefGoogle Scholar
  9. 9.
    Phillis, J. W., and Kirkpatrick, J. R., 1979, Can. J. Physiol. Pharmacol. 57:887–899.PubMedCrossRefGoogle Scholar
  10. 10.
    Morley, J. E., Melmed, S., Briggs, J., Carlson, H. E., Hershman, J. M., Solomon, T. E., Lamers, C., and Damassa, D. A., 1979, Life Sci. 25:1201–1206.PubMedCrossRefGoogle Scholar
  11. 11.
    Samson, W. K., and Lumpkin, M. D., 1981, Abstract, 63rd Annual Meeting of the Endocrine Society, Endocrine Society, Bethesda, p. 320.Google Scholar
  12. 12.
    Enjalbert, A., Arancibia, S., Ruberg, M., Priam, M., Bluet-Pajot, M. T., Rotsztejn, W. H., and Kordon, C., 1980, Neuroendocrinology 31:200–204.PubMedCrossRefGoogle Scholar
  13. 13.
    Said, S. I., and Mutt, V., 1970, Science 169:1217–1218.PubMedCrossRefGoogle Scholar
  14. 14.
    Larsson, L.-I., Fahrenkrug, J., Schaffalitzky de Muckadell, O. B., Sundler, F., Hakanson, R., and Rehfeld, J. F., 1976, Proc. Natl. Acad. Sci. U.S.A. 73:3197–3200.PubMedCrossRefGoogle Scholar
  15. 15.
    Alumets, J., Fahrenkrug, J., Hakanson, R., Schaffalitzky de Muckadell, O. B., Sundler, F., and Uddman, R., 1979, Nature 280:155–156.PubMedCrossRefGoogle Scholar
  16. 16.
    Fahrenkrug, J., Schaffalitzky de Muckadell, O. B., Holst, J. J., and Lindkeer Jensen, S., 1979, Am. J. Physiol. 237:E535–E540.PubMedGoogle Scholar
  17. 17.
    Ahrén, B., Alumets, J., Ericsson, M., Fahrenkrug, J., Fahrenkrug, L., Hakanson, R., Hedner, P., Lorén, I., Melander, A., Rerup, C., and Sundler, F., 1980, Nature 287:343–345.PubMedCrossRefGoogle Scholar
  18. 18.
    Lundberg, J. M., Hökfelt, T., Anggard, A., Uvnas-Wallensten, K., Brimijoin, S., Brodin, E., and Fahrenkrug, J., 1980, Neural Peptides and Neuronal Communication (E. Costa and M. Trabucchi, eds.), Raven Press, New York, pp. 25–36.Google Scholar
  19. 19.
    Loren, I., Emson, P. C., Fahrenkrug, J., Björklund, A., Alumets, J., Hakanson, R., and Sundler, F., 1979, Neuroscience 4:1953–1976.PubMedCrossRefGoogle Scholar
  20. 20.
    Marley, P. D., Emson, P. C., Hunt, S. P., and Fahrenkrug, J., 1981, Neurosci. Lett. 27:261–266.PubMedCrossRefGoogle Scholar
  21. 21.
    Roberts, G. W., Woodhams, P. L., Crów, T. J., and Polak, J. M., 1980, Brain Res. 195:471–475.PubMedCrossRefGoogle Scholar
  22. 22.
    Palkovits, M., Besson, J., and Rotsztejn, W., 1981, Brain Res. 213:455–459.PubMedCrossRefGoogle Scholar
  23. 23.
    Lundberg, J. M., Hökfelt, T., Anggard, A., Uvnas-Wallensten, K., Brimijoin, S., Brodin, E., and Fahrenkrug, J., 1980, Adv. Biochem. Psychopharmacol. 22:25–36.PubMedGoogle Scholar
  24. 24.
    Larsson, L.-I., 1977, Histochemistry 54:173–176.PubMedCrossRefGoogle Scholar
  25. 25.
    Gilbert, R. F. T., Emson, P. C., Fahrenkrug, J., Dee, G. M., Penman, E., and Wass, J., 1980, J. Neurochem. 34:108–113.PubMedCrossRefGoogle Scholar
  26. 26.
    Lundberg, J. M., 1981, Acta Physiol. Scand. (Suppl.) 496:1–57.Google Scholar
  27. 27.
    Lundberg, J. M., Anggard, A., Fahrenkrug, J., Hökfelt, T., and Mutt, V., 1980, Proc. Natl. Acad. Sci. U.S.A. 77:1651–1655.PubMedCrossRefGoogle Scholar
  28. 28.
    Goyal, R. K., Rattan, S., and Said, S. I., 1980, Nature 288:378–380.PubMedCrossRefGoogle Scholar
  29. 29.
    Eklund, S., Jodal, M., Lundgren, O., and Sjöqvist, A., 1979, Acta Physiol. Scand. 105:461–468.PubMedCrossRefGoogle Scholar
  30. 30.
    Edin, R., Lundberg, J. M., Ahlman, H., Dahlström, A., Fahrenkrug, J., Hökfelt, T., and Kewenter, J., 1979, Acta Physiol. Scand. 107:185–187.PubMedCrossRefGoogle Scholar
  31. 31.
    Fahrenkrug, J., Hanglund, U., Jodal, M., Lundgren, O., Olbe, L., and Schaffalitzky de Muckadell, O. B., 1978, J. Physiol. (Lond.) 284:291–305.Google Scholar
  32. 32.
    Larsen, L.-I., Fahrenkrug, J., and Holst, J. J., 1978, Life Sci. 22:773–780.CrossRefGoogle Scholar
  33. 33.
    Lindkaer, Jensen, S., Fahrenkrug, J., Holst, J. J., Vagn Nielsen, O., and Schaffalitzky de Muckadell, O. B., 1978, Am. J. Physiol. 235:387–391.Google Scholar
  34. 34.
    Ottesen, B., Larsen, J. J., Fahrenkrug, J., Stjernquist, M., and Sundler, F., 1981, Am. J. Physiol. 240:E32–E36.PubMedGoogle Scholar
  35. 35.
    Ottesen, B., Wagner, G., and Fahrenkrug, J., 1980, Prostaglandins 19:427–435.PubMedCrossRefGoogle Scholar
  36. 36.
    Taylor, D. P., and Pert, C. B., 1979, Proc. Natl. Acad. Sci. U.S.A. 76:660–664.PubMedCrossRefGoogle Scholar
  37. 37.
    Taylor, D. P., Pert, C. B., and Herkenham, M., 1979, Peptides: Structure and Biological Functions (E. Gross and J. Meidhalfer, eds.), Pierce Chemical, Rockford, IL, pp. 917–920.Google Scholar
  38. 38.
    Quick, M., Iversen, L. L., and Bloom, S. R., 1978, Biochem. Pharmacol. 27:2209–2213.CrossRefGoogle Scholar
  39. 39.
    Kerwin, R. W., Pay, S., Bhoola, K. D., and Pycock, C. J., 1980, J. Pharm. Pharmacol. 32:561–566.PubMedCrossRefGoogle Scholar
  40. 40.
    Borghi, C., Nicosia, S., Giachetti, A., and Said, S. I., 1979, Life Sci. 24:65–70.PubMedCrossRefGoogle Scholar
  41. 41.
    Giachetti, A., Said, S. I., Reynolds, R. C., and Koniges, F. C., 1977, Proc. Natl. Acad. Sci. U.S.A. 74:3424–3428.PubMedCrossRefGoogle Scholar
  42. 42.
    Emson, P. C., Fahrenkrug, J., Schaffalitzky de Muckadell, O. B., Jessell, T. M., and Iversen, L. L., 1978, Brain Res. 143:174–178.PubMedCrossRefGoogle Scholar
  43. 43.
    Bloom, S. R., and Edwards, A. V., 1980, J. Physiol. (Lond.) 299:437–452.Google Scholar
  44. 44.
    Phillis, J. W., Kirkpatrick, J. R., and Said, S. I., 1978, Can. J. Physiol. Pharmacol. 56:337–340.PubMedCrossRefGoogle Scholar
  45. 45.
    Dodd, J., Kelly, J. S., and Said, S. I., 1979, Br. J. Pharmacol. 66:125P–126P.PubMedGoogle Scholar
  46. 46.
    Dingledine, R., Dodd, J., and Kelly, J. S., 1980, J. Neurosci. Methods 2:323–362.PubMedCrossRefGoogle Scholar
  47. 47.
    Clark, W. G., Lipton, J. M., and Said, S. I., 1978, Neuropharmacology 17:883–885.PubMedCrossRefGoogle Scholar
  48. 48.
    Samson, W. K., Said, S. I., and McCann, S. M., 1979, Neurosci. Lett. 12:265–269.PubMedCrossRefGoogle Scholar
  49. 49.
    Besson, J., Rotsztejn, W., Laburthe, M., Epelbaum, J., Beaudet, A., Kordon, C., and Rosselin, G., 1979, Brain Res. 165:79–85.PubMedCrossRefGoogle Scholar
  50. 50.
    Said, S. I., and Porter, J. C., 1979, Life Sci. 24:227–230.PubMedCrossRefGoogle Scholar
  51. 51.
    Samson, W. K., Said, S. I., Snyder, G., and McCann, S. M., 1980, Peptides 1:325–352.PubMedCrossRefGoogle Scholar
  52. 52.
    Shaar, C. J., Clemens, J. A., and Dininger, N. B., 1979, Life Sci. 25:2071–2074.PubMedCrossRefGoogle Scholar
  53. 53.
    Vijayan, E., Samson, W. K., Said, S. I., and McCann, S. M., 1979, Endocrinology 104:53–57.PubMedCrossRefGoogle Scholar
  54. 54.
    Samson, W. K., Burton, K. P., Reeves, J. P., and McCann, S. M., 1981, Regul. Peptides 2:253–264.CrossRefGoogle Scholar
  55. 55.
    Epelbaum, J., Tapia-Arancibia, L., Besson, J., Rotsztejn, W. H., and Kordon, C., 1979, Eur. J. Pharmacol. 58:493–495.PubMedCrossRefGoogle Scholar
  56. 56.
    Gregory, R. A., and Tracy, H. J., 1964, Gut 5:103–117.PubMedCrossRefGoogle Scholar
  57. 57.
    Walsh, J. H., and Grossman, M. I., 1975, N. Engl. J. Med. 292:1324–1332.PubMedCrossRefGoogle Scholar
  58. 58.
    Berson, S. A., and Yalow, R. S., 1971, Gastroenterology 60:215–222.PubMedGoogle Scholar
  59. 59.
    Vanderhaeghen, J. J., Signeau, J. C., and Gepts, W., 1975, Nature 257:604–605.PubMedCrossRefGoogle Scholar
  60. 60.
    Rehfeld, J. F., 1978, Nature 271:771–773.PubMedCrossRefGoogle Scholar
  61. 61.
    Uvnas-Wallensten, K., Rehfeld, J. F., Larsson, L. I., and Uvnas, B., 1977, Proc. Natl. Acad. Sci. U.S.A. 74:5707–5710.PubMedCrossRefGoogle Scholar
  62. 62.
    Rehfeld, J. F., and Kruse-Larsen, C., 1978, Brain Res. 155:19–26.PubMedCrossRefGoogle Scholar
  63. 63.
    Uvnas-Wallensten, K., and Uvnas, B., 1978, Acta Physiol. Scand. 103:349–351.PubMedCrossRefGoogle Scholar
  64. 64.
    Vizi, E. S., Bertaccini, G., Impicciatore, M., and Knoll, J., 1972, Eur. J. Pharmacol. 17:175–178.PubMedCrossRefGoogle Scholar
  65. 65.
    Vizi, E. S., Bertaccini, G., Impicciatore, M., Mantovani, P., Zséli, J., and Knoll, J., 1974, Naunyn Schmiedebergs Arch. Pharmacol. 284:233–243.PubMedCrossRefGoogle Scholar
  66. 66.
    Telegdy, G., 1980, Acta Physiol. Acad. Sci. Hung. 55:273–281.PubMedGoogle Scholar
  67. 67.
    Várszegi, M., Fekete, M., Penke, B., Kovács, K., and Telegdy, G., 1981, Endocrinology, Neuropeptides-I (E. Stark, G. B. Makara, Z. Ács, E. Endröczi, eds.), Pergamon Press, London, pp. 215–219.Google Scholar
  68. 68.
    Várszegi, M., Fekete, M., Telegdy, G., Penke, B., and Kovács, K., 1980, Modulation of Neurochemical Transmission (E. S. Vizi, ed.), Pergamon Press, London, Akadémiai Kiadó, Budapest, pp. 439–449.Google Scholar
  69. 69.
    Nandi Majumder, A. P., and Nakhla, A. M., 1978, Experientia 34:974–975.CrossRefGoogle Scholar
  70. 70.
    Kelly, J. S., and Dodd, J., 1981, Neurosecretion and Brain Peptides, (J. B. Martin, S. Reichlin, and K. J. Blick, eds.), Raven Press, New York, pp. 133–144.Google Scholar
  71. 71.
    Della-Fera, M. A., and Baile, C. A., 1979, Science 206:471–473.PubMedCrossRefGoogle Scholar
  72. 72.
    Goltermann, N. R., Stengaard-Pedersen, K., Rehfeld, J. F., and Christensen, N. J., 1981, Neurochemistry 36:959–965.CrossRefGoogle Scholar
  73. 73.
    Vijayan, E., Samson, W. K., and McCann, S. M., 1978, Life Sci. 23:2225–2232.PubMedCrossRefGoogle Scholar
  74. 74.
    Telegdy, G., Fekete, M., Várszegi, M., and Kádár, T., 1980, Advances in Pharmacological Research and Practice (J. Knoll, E. S. Vizi, and M. Wolleman, eds.), Pergamon Press, pp. 169-185.Google Scholar
  75. 75.
    Itoh, S., Hirota, R., Katsuura, G., and Odaguchi, K., 1979, Endocrinol. Jpn. 26:741–744.PubMedCrossRefGoogle Scholar
  76. 76.
    Brown, J. C., Mutt, V., and Dryburgh, J. R., 1971, Can. J. Physiol. Pharmacol. 49:399–405.PubMedCrossRefGoogle Scholar
  77. 77.
    Brown, J. C., Cook, M. A., and Dryburgh, J. R., 1973, Can. J. Biochem. 51:533–537.PubMedCrossRefGoogle Scholar
  78. 78.
    Chey, W. Y., and Lee, K. Y., 1980, Clin. Gastroenterol. 9:645–656.PubMedGoogle Scholar
  79. 79.
    Yanaihara, C., Sato, H., Yanaihara, N., Naruse, S., Forssman, W. G., Helmstaedter, V., Fujita, T., Yamaguchi, K., and Abe, K., 1978, Adv. Exp. Biol. Med. 106:269–283.CrossRefGoogle Scholar
  80. 80.
    O’Donohue, T. L., Beinfeld, M., Chey, W. Y., and Jacobowitz, D. M., 1981, Soc. Neurosci. Abstr. 7:508.Google Scholar
  81. 81.
    O’Donohue, T. L., Charlton, C. G., Miller, R. L., Boden, G., and Jocobowitz, D. M., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:5221–5224.PubMedCrossRefGoogle Scholar
  82. 82.
    Chey, W. Y., Escoffery, R., Roth, F., Chang, T. M., and Yajima, H., 1980, Peptides (Suppl.) 1:S19.CrossRefGoogle Scholar
  83. 83.
    Nagai, K., Yanaihara, C., Yanaihara, N., Shimuzu, F., Kobayashi, S., and Fujita, T., 1980, Peptides (Suppl) 1:S78.CrossRefGoogle Scholar
  84. 84.
    O’Donohue, T. L., Beinfeld, M. C., Chey, W. Y., Chang, T. M., Nilaver, G., Zimmerman, E. A., Yajima, H., Adachi, H., Poth, M., McDevitt, R. P., and Jacobowitz, D. M., 1981, Peptides 2:467–477.PubMedCrossRefGoogle Scholar
  85. 85.
    Nilaver, G., Defendini, R., Zimmerman, E. A., Beinfeld, M. C., and O’Donohue, T. L., 1981, Soc. Neurosci. Abstr. 7:99.Google Scholar
  86. 86.
    Jacobowitz, D. M., O’Donohue, T. L., Chey, W. Y., and Chang, T. M., 1981, Peptides 2:479–487.PubMedCrossRefGoogle Scholar
  87. 87.
    Strunz, U., Domschke, W., Mitznegg, P., Domschke, S., Schubert, E., Wunsch, E., Jaeger, E., and Demling, L., 1975, Gastroenterology 68:1485–1491.PubMedGoogle Scholar
  88. 88.
    Christofides, N. D., Modlin, I. M., Fitzpatric, M. D., and Bloom, S. R., 1978, Gut 19:A436–437.Google Scholar
  89. 89.
    Koch, J., Domschke, S., Belohlavek, D., Domschke, W., Wunsch, E., Jaeger, E., and Demling, L., 1976, Scand. J. Gastroenterol. 11:93–96.PubMedGoogle Scholar
  90. 90.
    Konturek, S. J., Krol, R., Dembinski, A., and Wunsch, E., 1976, Pflugers Arch. 364:297–300.PubMedCrossRefGoogle Scholar
  91. 91.
    Erspamer, V., and Melchiorri, P., 1973, Pure Appl. Chem. 35:463–494.CrossRefGoogle Scholar
  92. 92.
    Polak, J. M., Ghatel, M. A., Wharton, J., Bishop, A. E., Bloom, S. R., Solcia, E., Brown, M. R., and Pearse, A. G. E., 1978, Scand. J. Gastroenterol. 13:S49–148.CrossRefGoogle Scholar
  93. 93.
    Walsh, J. H., Wong, H. C., and Dockray, G. J., 1979, Fed. Proc. 38:2315–2319.PubMedGoogle Scholar
  94. 94.
    Brown, M., and Vale, W., 1979, Trends Neurosci. 2:95–97.CrossRefGoogle Scholar
  95. 95.
    Lezoche, F., Ghatei, M. A., Carlei, F., Blackburn, A. M., Basso, N., Adrian, T. E., Speranza, V., and Bloom, S. R., 1979, Gasiroenterology 76:1185.Google Scholar
  96. 96.
    Brown, M. R., Rivier, J., and Vale, W., 1977, Life Sci. 21:1729.PubMedCrossRefGoogle Scholar
  97. 97.
    Rivier, J. E., and Brown, M. R., 1978, Biochemistry 17:1766.PubMedCrossRefGoogle Scholar
  98. 98.
    Gibbs, J., Fauser, D. J., Rowe, E. A., Rolls, B. J., Rolls, E. T., and Maddison, S. P., 1979, Nature 282:208–210.PubMedCrossRefGoogle Scholar
  99. 99.
    Morley, J. E., and Levine, A. S., 1980, Pharmacol. Biochem. Behav. 14:149–151.CrossRefGoogle Scholar
  100. 100.
    Dodd, J., and Kelly, J. S., 1981, Brain Res. 205:337–350.PubMedCrossRefGoogle Scholar
  101. 101.
    Pederson, R. A., Dryburgh, J. R., and Brown, J. C., 1975, Can. J. Physiol. Pharmacol. 53:1200.PubMedCrossRefGoogle Scholar
  102. 102.
    Brown, M., Rivier, J. E., Kobayashi, R., and Vale, W. W., 1978, Gut Hormones, Churchill Livingston, Edinburgh, pp. 550–558.Google Scholar
  103. 103.
    Vale, W., Rivier, C., Rivier, J., and Brown, M., 1978, Psychopharmacology: A Generation Progress (M. A. Lipton, ed.), Raven Press, New York, pp. 403–421.Google Scholar
  104. 104.
    Brown, M., Rivier, J., Wolfe, A., and Vale, W., 1977, Endocrinology 100:279.Google Scholar
  105. 105.
    Brown, M. R., and Fisher, D. A., 1980, Peptides: Integrators of Cell and Tissue Function (F. E. Bloom, ed.), Raven Press, New York, pp. 81–97.Google Scholar
  106. 106.
    McDonald, T. J., Jörnvall, H., Nilsson, G., Vagne, M., Ghatei, M., Bloom, S. R., and Mutt, V., 1979, Biochem. Biophys. Res. Commun. 90:227–233.PubMedCrossRefGoogle Scholar
  107. 107.
    Sundler, F., Hakanson, R., and Leander, S., 1980, Clin. Gastroenterol. 9:517–543.PubMedGoogle Scholar
  108. 108.
    Peach, M. J., 1977, Physiol. Rev. 57:313–370.PubMedGoogle Scholar
  109. 109.
    Regoli, D., Park, W. K., and Rioux, F., 1974, Pharmacol. Rev. 26:69–129.PubMedGoogle Scholar
  110. 110.
    Fuxe, K., Ganten, D., Hökfelt, T., and Bolme, P., 1976, Neurosci. Lett. 2:229–234.PubMedCrossRefGoogle Scholar
  111. 111.
    Hökfelt, T., Schultzberg, M., Johansson, O., Ljungdahl, A., Elfvin, L., Elde, R., Terenius, L., Nilsson, G., Said, S., and Goldstein, M., 1978, Gut Hormones (S. R. Bloom, ed.), Churchill Livingstone, Edinburgh, pp. 423–433.Google Scholar
  112. 112.
    Ganten, D., and Speck, G., 1978, Biochem. Pharmacol. 27:2379–2389.PubMedCrossRefGoogle Scholar
  113. 113.
    Osman, M. Y., Smeby, R. R., and Sen, S., 1979, Hypertension 1:53–60.PubMedCrossRefGoogle Scholar
  114. 114.
    Hirose, S., Ohsawa, T., Inagami, T., and Murakami, K., 1982, J. Biol. Chem. 257:6316–6321.PubMedGoogle Scholar
  115. 115.
    Hirose, S., Yokosawa, H., Inagami, T., and Workman, R. J., 1980, Brain Res. 91:489–499.CrossRefGoogle Scholar
  116. 116.
    Celio, M. R., Clemens, D. L., and Inagami, T., 1980, Biomed. Res. 1:427–431.Google Scholar
  117. 117.
    Inagami, T., Celio, M. R., Clemens, D. L., Lau, D., Takii, T., Kasselberg, A. G., and Hirose, S., 1980, Clin. Sci. 59:49–51.Google Scholar
  118. 118.
    Naruse, K., Takii, Y., and Inagami, T., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:7579–7583.PubMedCrossRefGoogle Scholar
  119. 119.
    Ganten, D., Fuxe, K., Ganten, U., Hökfelt, T., and Bolme, P., 1977, Hypertension and Brain Mechanisms (W. de Jong, A. P. Provoost, and A. P. Shapiro, eds.), Elsevier/North Holland Biomedical Press, Amsterdam, pp. 155–160.CrossRefGoogle Scholar
  120. 120.
    Fuxe, K., Ganten, D., Andersson, K., Calza, L., Agnati, L. F., Lang, R. E., Poulsen, K., Hökfelt, T., and Bernardis, P., 1982, The Renin-Angiotensin System in the Brain (D. Ganten, M. P. Printz, M. I. Philips, and B. A. Scholkens, eds.), Springer-Verlag, Berlin, pp. 208–232.CrossRefGoogle Scholar
  121. 121.
    Slater, E. E., Defendini, R., and Zimmerman, E., 1980, Proc. Natl Acad. Sci. U. S. A. 77:5458–5460.PubMedCrossRefGoogle Scholar
  122. 122.
    Inagami, T., 1982, Neuroendocrinology 35:475–482.PubMedCrossRefGoogle Scholar
  123. 123.
    Ganten, D., Marques-Julio, A., Granger, P., Hayduk, K., Karsunky, K. P., Boucher, R., and Genest, J., 1971, Am. J. Physiol. 221:1733–1737.PubMedGoogle Scholar
  124. 124.
    Ganten, D., Fuxe, K., Philips, M. I., Mann, J. F. E., and Ganten, U., 1978, Frontiers in Neuroendocrinology, Volume 5 (W. F. Ganong, and L. Martini, eds.), Raven Press, New York, pp. 61–99.Google Scholar
  125. 125.
    Yang, H.-Y., and Neff, N. H., 1972, J. Neurochem. 19:2443–2450.PubMedCrossRefGoogle Scholar
  126. 126.
    Yang, H.-Y., and Neff, N. H., 1973, J. Neurochem. 21:1035–1036.PubMedCrossRefGoogle Scholar
  127. 127.
    Fischer-Ferraro, C., Nahmod, V. E., Goldstein, D. J., and Finkielman, S., 1971, J. Exp. Med. 133:353–361.PubMedCrossRefGoogle Scholar
  128. 128.
    Bennet, J. B., and Snyder, S. H., 1976, J. Biol. Chem. 251:7423–7430.Google Scholar
  129. 129.
    McLean, A. S., Sirett, N. E., Bray, J. J., and Hubbard, J. I., 1975, Proc. Univ. Otago Med. School 53:19–20.Google Scholar
  130. 130.
    Philips, M. I., and Felix, D., 1976, Brain Res. 109:531–540.CrossRefGoogle Scholar
  131. 131.
    Philips, M. I., Felix, D., Hoffman, W. E., and Ganten, D., 1977, Neuroscience Symposium (W. M. Cowan, and J. A. Ferrendelli, eds.), Society for Neuroscience, Bethesda, pp. 308–339.Google Scholar
  132. 132.
    Nicoll, R. A., and Barker, J. L., 1971, Nature (New Biol.) 233:172–173.Google Scholar
  133. 133.
    Sakai, K. K., Marks, B. H., George, J., and Koestner, A., 1974, Life Sci. 14:1337–1344.PubMedCrossRefGoogle Scholar
  134. 134.
    Zimmerman, B. G., 1967, J. Pharmacol. Exp. Ther. 158:1–10.PubMedGoogle Scholar
  135. 135.
    Reit, E., 1972, Fed. Proc. 31:1338–1343.PubMedGoogle Scholar
  136. 136.
    Panisset, J. C., 1967, Can. J. Physiol. Pharmacol. 45:313–317.PubMedCrossRefGoogle Scholar
  137. 137.
    Fitzsimons, J. T., 1971, Proc. R. Soc. Med. 64:1074.PubMedGoogle Scholar
  138. 138.
    Severs, W. B., Summy-Long, J., Taylor, J. S., and Connor, J. P., 1970, J. Pharmacol. Exp. Ther. 174:27–34.PubMedGoogle Scholar
  139. 139.
    Simpson, J. B., 1981, Neuroendocrinology 32:248–256.PubMedCrossRefGoogle Scholar
  140. 140.
    Buggy, J., and Johnson, A. K., 1977, Am. J. Physiol. 233:R44–R52.PubMedGoogle Scholar
  141. 141.
    Swanson, L. W., and Sharpe, L. G., 1973, Am. J. Physiol. 225:566–572.PubMedGoogle Scholar
  142. 142.
    Johnson, A. K., and Epstein, A. N., 1975, Brain Res. 86:399–418.PubMedCrossRefGoogle Scholar
  143. 143.
    Fitzsimons, J. T., and Setler, P. E., 1975, J. Physiol. (Lond.) 250:613–631.Google Scholar
  144. 144.
    Setler, P. E., 1973, The Neuropsychology of Thirst (A. N. Epstein, H. R. Kissileff, and E. Stellar, eds.), H. V. Winston, Washington, pp. 279–291.Google Scholar
  145. 145.
    Buckley, J. P., and Jandhyala, B. S., 1977, Life Sci. 20:1485–1494.PubMedCrossRefGoogle Scholar
  146. 146.
    Buckley, J. P., 1981, Trends Pharmacol. Sci. 22:161–162.CrossRefGoogle Scholar
  147. 147.
    Hutchinson, J. S., Schelling, P., Möhring, J., and Ganten, D., 1976, Endocrinology 99:819–823.PubMedCrossRefGoogle Scholar
  148. 148.
    Fitzsimons, J. T., 1978, Fed. Proc. 37:2669–2675.PubMedGoogle Scholar
  149. 149.
    Keil, L. C., Summy-Long, J., and Severs, W. B., 1975, Endocrinology 96:1063–1065.PubMedCrossRefGoogle Scholar
  150. 150.
    Simonnet, G., Rodriguez, F., Fumoux, F., Czernichow, P., and Vincent, J. D., 1979, Am. J. Physiol. 237:R20–R25.PubMedGoogle Scholar
  151. 151.
    Lang, R. E., Rascher, W., Heil, J., Unger, T., Wiedemann, G., and Ganten, D., 1981, Life Sci. 29:1425–1428.PubMedCrossRefGoogle Scholar
  152. 152.
    Gagnon, D. J., Sirois, P., and Boucher, P. J., 1975, Clin. Exp. Pharmacol. Physiol. 2:305–313.PubMedCrossRefGoogle Scholar
  153. 153.
    Kimmel, J. R., Pollock, H. G., and Hazelwood, R. L., 1968, Endocrinology 83:1323–1330.PubMedCrossRefGoogle Scholar
  154. 154.
    Chance, R. E., 1972, Diabetes 21(Suppl. 2):536.Google Scholar
  155. 155.
    Chance, R. E., and Jones, W. E., 1974, United States Patent Office 842:/3/, 063.Google Scholar
  156. 156.
    Orci, L., Malaisse-Lagae, F., Baetens, D., and Perrelet, A., 1978, Lancet 2:1200.PubMedCrossRefGoogle Scholar
  157. 157.
    Loren, I., Alumets, J., Häkansson, R., and Sundler, F., 1979, Cell Tissue Res. 200:179–186.PubMedCrossRefGoogle Scholar
  158. 158.
    Hökfelt, T., Lundberg, J. M., Terenius, L., Jansco, G., and Kimmel, J., 1981, Peptides 2:81–87.PubMedCrossRefGoogle Scholar
  159. 159.
    Lundberg, J., Hökfelt, T., Anggard, A., Kimmel, J., Goldstein, M., and Markey, K., 1980, Acta Physiol. Scand. 110:107–109.PubMedCrossRefGoogle Scholar
  160. 160.
    Hunt, S. P., Emson, P. C., Gilbert, R., Goldstein, M., and Kimmel, J. R., 1981, Neurosci. Lett. 21:125–130.PubMedCrossRefGoogle Scholar
  161. 161.
    Hazelwood, R. L., and Turner, S. D., 1973, Gen. Comp. Endocrinol. 21:485–497.PubMedCrossRefGoogle Scholar
  162. 162.
    Lin, T.-M., and Chance, R. E., 1978, Gut Hormones, Churchill Livingstone, Edinburgh, pp. 242–246.Google Scholar
  163. 163.
    Greenberg, G. R., McCloy, R. F., Chadwick, V. S., Adrian, T. E., Baron, J. H., and Bloom, S. R., 1979, Am. J. Dig. Dis. 24:11–14.CrossRefGoogle Scholar
  164. 164.
    Greenberg, G. R., McCloy, R. F., Adrian, T. E., Baron, J. H., and Bloom, S. R., 1978, Acta Hepato-Gastroenterol. 25:384–387.Google Scholar
  165. 165.
    Greenberg, G. R., McCloy, R. F., Adrian, T. E., Chadwick, V. S., Baron, J. H., and Bloom, S. R., 1978, Lancet 2:1280–1282.PubMedCrossRefGoogle Scholar
  166. 166.
    Fuxe, K., Agnati, L. F., Härfstrand, A., Lundberg, J., Hökfelt, T., Calza, L., Kimmel, J., and Bernardi, P., 1982, Acta Physiol. Scand. 115:381–384.PubMedCrossRefGoogle Scholar
  167. 167.
    Lundberg, J., Anggard, A., Hökfelt, T., and Kimmel, J., 1980, Acta Physiol. Scand. 110:199–201.PubMedCrossRefGoogle Scholar
  168. 168.
    Rosenzweig, J. L., Havrankova, J., Brownstein, M., and Roth, J., 1980, Endocrinology, Neuroendocrinology, Neuropeptides-I (E. Stark, G. B. Makara, Z. cs, and E. Endröczi, eds.), Pergamon Press, London, pp. 175–186.Google Scholar
  169. 169.
    Havrankova, J., Schmechel, D., Roth, J., and Brownstein, M., 1978, Proc. Natl. Acad. Sci. U.S.A. 75:5737–5741.PubMedCrossRefGoogle Scholar
  170. 170.
    Havrankova, J., Brownstein, M. J., and Roth, J., 1979, J. Clin. Invest. 64:636–642.PubMedCrossRefGoogle Scholar
  171. 171.
    Eng, J., and Yalow, R. S., 1980, Diabetes 29:105–109.PubMedCrossRefGoogle Scholar
  172. 172.
    Havrankova, J., Roth, J., and Brownstein, M., 1978, Nature 272:827–829.PubMedCrossRefGoogle Scholar
  173. 173.
    van Houten, M., Posner, B. I., Kopriwa, B. M., and Brawer, J. R., 1979, Endocrinology 105:666–673.PubMedCrossRefGoogle Scholar
  174. 174.
    van Houten, M., and Posner, B. I., 1979, Nature 282:623–625.PubMedCrossRefGoogle Scholar
  175. 175.
    van Houten, M., Posner, B. I., Kopriwa, B. M., and Brawer, J. R., 1980, Science 207:1081–1083.PubMedCrossRefGoogle Scholar
  176. 176.
    Pansky, B., and Hatfield, J. S., 1978, Am. J. Anat. 153:459–467.PubMedCrossRefGoogle Scholar
  177. 177.
    Cruz, L., and Antonetty, C., 1980, Endocrinology, Neuroendocrinology, Neuropeptides-I (E. Stark, G. B. Makara, Z. Ács, and E. Endröczi, eds.), Pergamon Press, London, pp. 187–192.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Gyula Telegdy
    • 1
  1. 1.Institute of PathophysiologyUniversity Medical SchoolSzegedHungary

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