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Amphibian Herpesviruses

  • Allan Granoff
Part of the The Viruses book series (VIRS)

Abstract

Amphibian herpesviruses might never have been studied had Lucké (1934) not discovered that cells of the renal adenocarcinoma of the common leopard frog, Rana pipiens, frequently contain intranuclear acidophilic inclusion bodies similar to those found in herpes simplex infections and other viral diseases. On the strength of this observation, and results of subsequent experiments, Lucké concluded that the frog renal adenocarcinoma was of viral origin—an interpretation that was unequivocally substantiated more than three decades later when a herpesvirus was firmly established as the causative agent (reviewed in Naegele and Gran-off, 1980). During experiments to isolate and cultivate the Lucké herpesvirus in vitro, Rafferty (1965) isolated a herpesvirus that was distinct from the Lucké tumor herpesvirus (Gravell et al., 1968; Gravell, 1971). These remain the only two herpesviruses isolated from amphibia, and by comparison with other herpesviruses, little is known of their properties and interaction with host cells. This chapter will summarize the relevant available information on the two amphibian herpesviruses and, where possible, point out reasons for the paucity of information on them.

Keywords

Ascitic Fluid Renal Carcinoma Intranuclear Inclusion Leopard Frog Tumor Fragment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Breidenbach, G.P., Skinner, M.S., Wallace, J.H., and Mizell, M., 1971, In-vitro induction of a herpes-type virus in “summer-phase” Lucké tumor explants, J. Virol. 7: 679.Google Scholar
  2. Collard, W., Thornton, H., Mizell, M., and Green, M., 1973, Virus-free adenocarcinoma of the frog (summer phase tumor) transcribes Lucké tumor herpesvirus-specific RNA, Science 181: 448.PubMedCrossRefGoogle Scholar
  3. Fawcett, D.W., 1956, Electron microscope observations of intracellular virus-like particles associated with the cells of the Lucké renal adenocarcinoma, J. Biophys. Biochem. Cytol. 2: 725.PubMedCrossRefGoogle Scholar
  4. Freed, J.J., Mezger-Freed, L., and Shatz, S.A., 1969, Characteristics of cell lines from haploid and diploid anuran embryos, in: Recent Results in Cancer Research, Special Supplement ( M. Mizell, ed.), p. 101, Springer-Verlag, New York.Google Scholar
  5. Granoff, A., 1969, Viruses of Amphibia, Curr. Top. Microbiol. Immunol. 50: 107.PubMedCrossRefGoogle Scholar
  6. Granoff, A., 1972, Herpesvirus and frog renal adenocarcinoma, Fed. Proc. Fed. Am. Soc. Exp. Biol. 31: 1626.Google Scholar
  7. Granoff, A., 1973, The Lucké renal carcinoma of the frog, in: The Herpesviruses ( A. Kaplan, ed.), p. 627, Academic Press, New York.Google Scholar
  8. Granoff, A., and Darlington, R.W., 1969, Viruses and renal carcinoma of Rana pipiens. VIII. Electron microscopic evidence for the presence of herpesvirus in the urine of a Lucké tumor-bearing frog, Virology 38: 197.PubMedCrossRefGoogle Scholar
  9. Granoff, A., and Naegele, R.F., 1978, The Lucké tumor: A model for persistent virus infection and oncogenesis, in: Persistent Viruses, Vol. XI ( J. Stevens, G. Todaro, and F.C. Fox, eds.), p. 15, ICN-UCLA Symposia on Molecular and Cellular Biology, Academic Press, New York.Google Scholar
  10. Granoff, A., Gravell, M., and Darlington, R.W., 1969, Studies on the viral etiology of the renal adenocarcinoma of Rana pipiens (Lucké tumor), in: Recent Results in Cancer Research ( M. Mizell, ed.), p. 279, Springer-Verlag, Berlin—Heidelberg—New York.Google Scholar
  11. Gravell, M., 1971, Viruses and renal carcinoma of Rana pipiens. X. Comparison of herpes-type viruses associated with Lucké tumor-bearing frogs, Virology 43:730.Google Scholar
  12. Gravell, M., Granoff, A., and Darlington, R.W., 1968, Viruses and renal carcinoma of Rana pipiens. VII. Propagation of a herpes-type frog virus Virology 36 :467.Google Scholar
  13. Honess, R.W., and Watson, D.H., 1977, Unity and diversity in the herpesviruses J. Gen. Virol. 37 :15.Google Scholar
  14. Kemper, J.D., 1977, Leopard frog supply, Science 197: 106.CrossRefGoogle Scholar
  15. Lucké, B., 1934, A neoplastic disease of the kidney of the frog Rana pipiens Am. J. Cancer 20 :352.Google Scholar
  16. Lucké, B., 1938, Carcinoma in the leopard frog: Its probable causation by a virus, J. Exp. Med. :457.Google Scholar
  17. Lucké, B., 1952, Kidney carcinoma in the leopard frog: A virus tumor Ann. N.Y. Acad. Sci. 54 :1093.Google Scholar
  18. Lucké, B., and Schlumberger, H., 1939, The manner of growth of frog carcinoma studied by direct microscopic examination of living intraocular transplants, J. Exp. Med. 70: 257.PubMedCrossRefGoogle Scholar
  19. Lunger, P.D., 1964, The isolation and morphology of the Lucké frog kidney tumor virus,Virology 24: 138.Google Scholar
  20. Lunger, P.D., Darlington, R.W., and Granoff, A., 1965, Cell—virus relationships in the Lucké renal adenocarcinoma: An ultrastructure study, Ann. N.Y. Acad. Sci. 126: 289.PubMedCrossRefGoogle Scholar
  21. McKinnell, R.G., 1965, Incidence and histology of renal tumors of leopard frogs from the north central states, Ann. N.Y. Acad. Sci. 126: 85.PubMedCrossRefGoogle Scholar
  22. McKinnell, R.G., and McKinnell, B.K., 1968, Seasonal fluctuation of frog renal adenocarcinoma prevalence in natural populations, Cancer Res. 28: 440.PubMedGoogle Scholar
  23. Mizell, M., Stackpole, C.W., and Halperen, S., 1968, Herpes-type virus recovery from “virus-free” frog kidney tumors, Proc. Soc. Exp. Biol. Med. 127: 808.PubMedGoogle Scholar
  24. Mizell, M., Toplin, I., and Isaacs, J.J., 1969, Tumor induction in developing frog kidneys by a zonal centrifuge purified fraction of the frog herpes-type virus, Science 165: 1134.PubMedCrossRefGoogle Scholar
  25. Morek, D.M., and Tweedell, K.S., 1969, Interaction of normal and malignant tissues in organ culture, Am. Zool. 9: 1125.Google Scholar
  26. Mulcare, D.J., 1969, Non-specific transmission of the Lucké tumor, in: Recent Results in Cancer Research: Biology of Amphibian Tumors ( M. Mizell, ed.), p. 240, Springer-Verlag, New York.Google Scholar
  27. Naegele, R.F., and Granoff, A., 1972, Viruses and renal carcinoma of Rana pipiens. XIII. Transmission of the Lucké tumor by herpesvirus-containing ascitic fluid from a tumor-bearing frog, J. Natl. Cancer Inst. 49: 299.PubMedGoogle Scholar
  28. Naegele, R.F., and Granoff, A., 1977, Viruses and renal carcinoma of Rana pipiens. XV. The presence of virus-associated membrane antigen(s) on Lucké tumor cells, Int. J. Cancer 19: 414.PubMedCrossRefGoogle Scholar
  29. Naegele, R.F., and Granoff, A., 1980, The Lucké tumor and its herpesvirus, in: Oncogenic Herpesviruses (F. Rapp, ed.), p. 85, CRC Press, Boca Raton, Florida.Google Scholar
  30. Naegele, R.F., Granoff, A., and Darlington, R.W., 1974, The presence of the Lucké herpes-virus genome in induced tadpole tumors and its oncogenicity: Koch—Henle postulates fulfilled, Proc. Natl. Acad. Sci. U.S.A. 71: 830.PubMedCrossRefGoogle Scholar
  31. Rafferty, K.A., Jr., 1963, Spontaneous kidney tumors in the frog: Rate of occurrence in isolated adults, Science 141: 720.PubMedCrossRefGoogle Scholar
  32. Rafferty, K.A., Jr., 1964, Kidney tumors of the leopard frog: A review, Cancer Res. 24: 169.PubMedGoogle Scholar
  33. Rafferty, K.A., Jr., 1965, The cultivation of inclusion-associated viruses from Lucké tumor frogs, Ann. N.Y. Acad. Sci. 126: 3.PubMedCrossRefGoogle Scholar
  34. Rafferty, K.A., jr., and Rafferty, N.S., 1961, High incidence of transmissible kidney tumors in uninoculated frogs maintained in a laboratory, Science 133: 702.PubMedCrossRefGoogle Scholar
  35. Rivers, T.M., 1936, Viruses and Koch’s postulates, J. Bacteriol. 33: 1.Google Scholar
  36. Roberts, M.E., 1963, Studies on the transmissibility and cytology of the renal carcinoma of Rana pipiens, Cancer Res. 23: 1709.PubMedGoogle Scholar
  37. Schlumberger, H., and Lucké, B., 1949, Serial intraocular transplantation of frog carcinoma for 14 generations, Cancer Res. 9: 52.PubMedGoogle Scholar
  38. Skinner, M.S., and Mizell, M., 1972, The effect of different temperatures on herpesvirus induction and replication in Lucké tumor explants, Lab. Invest. 26: 671.PubMedGoogle Scholar
  39. Toplin, I., Mizell, M., Sottong, P., and Monroe, J., 1971, Zonal centrifuge applied to the purification of herpesvirus in the Lucké frog kidney tumor, Appl. Microbiol. 21: 132.PubMedGoogle Scholar
  40. Tweedell, K.S., 1967, Induced oncogenesis in developing frog kidney cells, Cancer Res. 27: 2042.Google Scholar
  41. Tweedell, K.S., 1972, Experimental alteration of the oncogenicity of frog tumor cell-viral fractions, Proc. Soc. Exp. Biol. Med. 140: 1246.PubMedGoogle Scholar
  42. Tweedell, K., and Wong, W.Y., 1974, Frog kidney tumors induced by herpesvirus cultured in pronephric cells, J. Natl. Cancer Inst. 52: 621.PubMedGoogle Scholar
  43. Wagner, E.K., Roizman, B., Savage, T., Spear, P.G., Mizell, M., Dun, F.E., and Sypowiez,D., 1970, Characterization of the DNA of herpesviruses associated with the Lucké adenocarcinoma of the frog and Burkitt lymphoma of man, Virology 42: 257.PubMedCrossRefGoogle Scholar
  44. Zambemard, J., and Mizell, M., 1965, Virus particles of the frog renal adenocarcinoma:Causative agent of passenger virus? I. Fine structure of primary tumors and subsequent intraocular transplants, Ann. N.Y. Acad. Sci. 126: 127.CrossRefGoogle Scholar
  45. Zambemard, J., and Vatter, A.E., 1966, The effect of temperature change upon inclusion-containing renal tumor cells of leopard frogs, Cancer Res. 26: 2148.Google Scholar
  46. Zambemard, J., Vatter, A.E., and McKinnell, R.G., 1966, The fine structure of nuclear and cytoplasmic inclusions in primary renal tumors of mutant leopard frogs, Cancer Res. 26: 1688.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Allan Granoff
    • 1
  1. 1.Division of VirologySt. Jude Children’s Research HospitalMemphisUSA

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