Amphibian Herpesviruses

  • Allan Granoff
Part of the The Viruses book series (VIRS)


Amphibian herpesviruses might never have been studied had Lucké (1934) not discovered that cells of the renal adenocarcinoma of the common leopard frog, Rana pipiens, frequently contain intranuclear acidophilic inclusion bodies similar to those found in herpes simplex infections and other viral diseases. On the strength of this observation, and results of subsequent experiments, Lucké concluded that the frog renal adenocarcinoma was of viral origin—an interpretation that was unequivocally substantiated more than three decades later when a herpesvirus was firmly established as the causative agent (reviewed in Naegele and Gran-off, 1980). During experiments to isolate and cultivate the Lucké herpesvirus in vitro, Rafferty (1965) isolated a herpesvirus that was distinct from the Lucké tumor herpesvirus (Gravell et al., 1968; Gravell, 1971). These remain the only two herpesviruses isolated from amphibia, and by comparison with other herpesviruses, little is known of their properties and interaction with host cells. This chapter will summarize the relevant available information on the two amphibian herpesviruses and, where possible, point out reasons for the paucity of information on them.


Ascitic Fluid Renal Carcinoma Intranuclear Inclusion Leopard Frog Tumor Fragment 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Allan Granoff
    • 1
  1. 1.Division of VirologySt. Jude Children’s Research HospitalMemphisUSA

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