Biology and Properties of Fish and Reptilian Herpesviruses

  • Ken Wolf
Part of the The Viruses book series (VIRS)


This chapter updates and adds to information contained in earlier reviews of herpesvirus of reptiles and fishes (Wolf, 1973, 1979 Lunger; and Clark, 1978; Clark and Lunger, 1981). This review includes at least 11, and possibly as many as 14, herpesviruses (Table I). The uncertainty of number stems from the fact that some of the agents have yet to be isolated, and therefore their antigenic, serological, and other critical relationships are unknown. Furthermore, the rather high degree of host specificity exhibited by most herpesviruses suggests the possibility that the two freshwater turtles (both family Testudinidae) could well be afflicted with a single virus. The same is true for the agent(s) seen in the venom of the three snakes of the family Elapidae; two of the snakes are members of the genus Naja, and all three share a common geographic area.


Rainbow Trout Chum Salmon Channel Catfish Masu Salmon Intranuclear Inclusion 
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  1. Bowser, P.R., 1976, Fluorescent and antibody test for channel catfish virus, Fish Health News 5: 4.Google Scholar
  2. Bowser, P.R., and Plumb, J.A., 1980, Channel catfish virus: Comparative replication and sensitivity of cell lines from channel catfish ovary and the brown bullhead, J. Wildl. Dis. 16:451.PubMedGoogle Scholar
  3. Buchanan, J.S., and Madeley, C.R., 1978, Studies on Herpesvirus scophthalmi infection of turbot Scophthalmus maximus L. Ultrastructural observations, J. Fish Dis. 1:283.CrossRefGoogle Scholar
  4. Buchanan, J.S., Richards, R.H., Sommerville, C., and Madeley, C.R., 1978, A herpes-type virus from turbot (Scophthalmus maximus L.), Vet. Rec. 102:527.PubMedCrossRefGoogle Scholar
  5. Chousterman, S., Lacasa, M., and Sheldrick, P., 1979, Physical map of the channel catfish virus genome: Location of sites for restriction endonucleases Eco RI, Hind III, Hpa I, and Xba I, J. Virol. 31:73.PubMedGoogle Scholar
  6. Clark, H.F., and Karzon, D.T., 1972, Iguana virus, a herpes-like virus isolated from cultured cells of a lizard, Iguana iguana, Infect. Immun. 5:559.PubMedGoogle Scholar
  7. Clark, H.F., and Lunger, P.D., 1981, Viruses of reptiles, In: Diseases of Reptilia (J.E. Cooper and D.F. Jackson, eds.), pp. 135–164, Academic Press, New York.Google Scholar
  8. Cox, W.R., Rapley, W.A., and Barker, I.K., 1980, Herpesvirus-like infection in a painted turtle (Chrysemys picta), J. Wildl. Dis. 16:445.PubMedGoogle Scholar
  9. Fijan, N., 1968, Progress report on acute mortality of channel catfish caused by a virus, Off. Int. Epizoot. Bull. 69:1167.Google Scholar
  10. Frye, F.L., Oshiro, L.O., Dutra, F.R., and Carney, J.D., 1977, Herpesvirus-like infection in two Pacific pond turtles, J. Am. Vet. Med. Assoc. 171:882.PubMedGoogle Scholar
  11. Goodheart, C.R., and Plummer, G., 1975, The densities of herpesviral DNAs, Prog. Med. Vitol. 19:324.Google Scholar
  12. Haines, H., 1978, A herpesvirus disease of green sea turtles in aquaculture, Mar. Fish Rev. Paper 1294:33.Google Scholar
  13. Haines, H., and Kleese, W.C., 1977, Effect of water temperature on a herpesvirus infection of sea turtles, Infect. Immun. 15:756.PubMedGoogle Scholar
  14. Heartwell, C.M., 1975, Immune response and antibody characterization of the channel catfish (Ictalurus punctatus) to a naturally pathogenic bacterium and virus, U.S. Fish Wildl. Serv. Tech. Paper 85:34.Google Scholar
  15. Kelly, R.K., Nielsen, O., and Yamamoto, T., 1980a, A new herpes-like virus (HLV) of fish (Stizostedion vitreum vitreum), In Vitro 16:255.Google Scholar
  16. Kelly, R.K., Nielsen, O., Campbell, J.S., and Yamamoto, T., 1980b, Current status of lymphocystis, dermal sarcoma/fibroma, and related diseases in walleye, Stizostedion vitreum vitreum, in western Canada, In: Proceedings of the Fourth Biennial Fish Health Section and Fish Disease Workshops, Seattle, Washington (mimeographed).Google Scholar
  17. Kimura, T., Yoshimizu, M., Tanaka, M., and Sannohe, H., 1981a, Studies on a new virus (OMV) from Oncorhynchus masou. I. Characteristics and pathogenicity, Fish Pathol. 15:143–147.CrossRefGoogle Scholar
  18. Kimura, T., Yoshimizu, M., and Tanaka, M., 1981b, Studies on a new virus (OMV) from Oncorhynchus masou. II. Oncogenic nature, Fish Pathol. 15:149–153.CrossRefGoogle Scholar
  19. Kimura, T., Yoshimizu, M., and Tanaka, M., 1981c, Fish viruses: Tumor induction in Oncorhynchus keta by the herpesvirus, In: Phyletic Approach to Cancer. C.J. Dawe, J.C. Harshbarger, T. Sugimura, S. Takayama, and S. Kodo, eds., pp. 59–68, Japan Sci. Soc. Press, Tokyo.Google Scholar
  20. Koment, R.W., and Haines, H.G., 1977, A new reptilian herpesvirus isolated from the green sea turtle, Chelonia mydas,Abstr. Annu. Meet. Am. Soc. Microbiol. New Orleans, Louisiana, May 8–13, p. 347.Google Scholar
  21. Koment, R.W., and Haines, H., 1978, Decreased antiviral effect of phosphonacetic acid on the poikilothermic herpesvirus of channel catfish disease, Proc. Soc. Exp. Biol. Med. 159:21.PubMedGoogle Scholar
  22. Lowenthal, W., 1907, Einschlussartige Zell und Kernveränderungen in der Karpfenpocke, Z. Krebsforsch. 5:197.CrossRefGoogle Scholar
  23. Lunger, P.D., and Clark, H.F., 1978, Reptilia-related viruses, In: Advances in Virus Research (M.A. Lauffer, K. Maramorosch, F.B. Bang, and K.M. Smith, eds.), pp. 159–204, Academic Press, New York.Google Scholar
  24. Major, R.D., McCraren, J.P., and Smith, C.E., 1975, Histopathological changes in channel catfish (Ictalurus punctatus) experimentally and naturally infected with channel catfish virus disease, J. Fish. Res. Board Can. 32:563.CrossRefGoogle Scholar
  25. McCraren, J.P., 1972, Channel catfish virus disease (CCVD): A current review, Proc. Annu. Conf. Western Assoc. Game Fish Comm. 52:528.Google Scholar
  26. Monroe, J.H., Shibley, G.P., Schidlovsky, G., Nakai, T., Howatson, A.F., Wivel, N.W., and O’Conner, T.E., 1968, Action of snake venom on Rauscher virus, J. Natl. Cancer Inst. 40:135.PubMedGoogle Scholar
  27. Padgett, F., and Levine, A.S., 1966, Fine structure of the Rauscher leukemia virus as revealed by incubation in snake venom, Virology 30:623.PubMedCrossRefGoogle Scholar
  28. Plumb, J.A., 1973a, Effects of temperature on mortality of fingerling channel catfish (Ictalurus punctatus) experimentally infected with channel catfish virus, J. Fish. Res. Board Can. 30:568.CrossRefGoogle Scholar
  29. Plumb, J.A., 1973b, Neutralization of channel catfish virus by serum of channel catfish, J. Wildl. Dis. 9:324.Google Scholar
  30. Plumb, J.A., 1977, Channel catfish virus disease, U.S. Fish Wildl. Serv. Fish Dis. Leaflet 52:8.Google Scholar
  31. Plumb, J.A., and Gaines, J.L., Jr., 1975, Channel catfish virus disease, In: Pathology of Fishes (W.E. Ribelin and G. Migaki, eds.), pp. 287–302, University of Wisconsin Press, Madison.Google Scholar
  32. Plumb, J.A., Gaines, J.L., Mora, E.C., and Bradley, G.G., 1974, Histopathology and electron microscopy of channel catfish virus in infected channel catfish, Ictalurus punctatus (Rafinesque), J. Fish Biol. 6:661.CrossRefGoogle Scholar
  33. Plumb, J.A., Green, O.L., Smithermann, R.O., and Pardue, G.B., 1975, Channel catfish virus experiments with different strains of channel catfish, Trans. Am. Fish. Soc. 104:140.CrossRefGoogle Scholar
  34. Raynaud, A., and Adrian, M., 1976, Lésions cutanées â structure papillomateuse associées â des virus chez le lézard vert (Lacerta virdis Laura, C. R. Acad. Sci. Ser. D 283:845.Google Scholar
  35. Rebell, G., Rywlin, A., and Haines, H., 1975, A herpesvirus-type agent associated with skin lesions of green sea turtles in aquaculture, Am. J. Vet. Res. 36: 1221.PubMedGoogle Scholar
  36. Richards, R.H., and Buchanan, J.S., 1978, Studies on Herpesvirus scophthalmi infection of turbot Scophthalmus maximus (L.): Histopathological observations, J. Fish Dis. 1:3.CrossRefGoogle Scholar
  37. Sano, T., 1976, Viral diseases of cultured fishes in Japan, Fish Pathol. 10:221.CrossRefGoogle Scholar
  38. Schubert, G., 1964, Elektronenmikroskopische Untersuchungen zur Pockenkrankheit des Karpfens, Z. Naturforsch. 19:675.Google Scholar
  39. Schubert, G.H., 1966, The infective agent in carp pox, Off. Int. Epizoot. Bull. 65:1011.Google Scholar
  40. Simpson, C.F., Jacobson, E.R., and Gaskin, J.M., 1979, Herpesvirus-like infection of the venom gland of Siamese cobras, J. Am. Vet. Med. Assoc. 175:941.PubMedGoogle Scholar
  41. Sonstegard, R.A., and Sonstegard, K.S., 1978, Herpesvirus-associated epidermal hyperplasia in fish (carp), In: Proceedings of the International Symposium on Oncogenesis and Herpesviruses III (G. De-Thé, W. Henle, and F. Rapp, eds.), pp. 863–868, International Agency for Research on Cancer, Scientific Publication No. 24, Lyon, France.Google Scholar
  42. Walker, R., 1969, Virus associated with epidermal hyperplasia in fish, Natl. Cancer Inst. Monogr. 31:195.PubMedGoogle Scholar
  43. Wolf, K., 1973, Herpesviruses of lower vertebrates, In: The Herpesviruses (A.S. Kaplan, ed.), pp. 495–520, Academic Press, New York.Google Scholar
  44. Wolf, K., 1979, Comparative pathogenesis and virulence of poikilotherm vertebrate herpesviruses, In: Proceedings of the 4th Munich Symposium on Microbiology on Mechanisms of Viral Pathogenesis and Virulence (P.A. Bachmann, ed.), pp. 183–200, WHO Collaborating Centre for Collection and Evaluation of Data on Comparative Virology.Google Scholar
  45. Wolf, K., and Darlington, R.W., 1971, Channel catfish virus: A new herpesvirus of ictalurid fish, J.Virol. 8:525.PubMedGoogle Scholar
  46. Wolf, K., and Mann, J.A., 1980, Poikilotherm vertebrate cell lines and viruses: A current listing for fishes, In Vitro 16:179.CrossRefGoogle Scholar
  47. Wolf, K., and Smith„ C.E., 1981, Herpesvirus salmonis: Pathological changes in parenterally infected rainbow trout fry, J. Fish Dis., 445:457.Google Scholar
  48. Wolf, K., Herman, R.L., and Carlson, C.P., 1972, Fish viruses: Histopathologic changes associated with experimental channel catfish virus disease, J. Fish. Res. Board Can. 29:149.CrossRefGoogle Scholar
  49. Wolf, K., Sano, T., and Kimura, T., 1975, Herpesvirus disease of salmonids, U.S. Fish Wildl. Serv. Fish Dis. Leaflet 44:8.Google Scholar
  50. Wolf, K., Darlington, R.W., Taylor, W.G., Quimby, M.C., and Nagabayashi, T., 1978, Herpesvirus salmonis: Characterization of a new pathogen of rainbow trout,J. Virol. 27:659.PubMedGoogle Scholar
  51. Zeigel, R.F., and Clark, H.F., 1972, Electron microscopy observations on a new herpes-type virus isolated from Iguana iguana and propagated in reptilian cells in vitro, Infect. Immun. 5:570.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Ken Wolf
    • 1
  1. 1.National Fish Health Research LaboratoryU.S. Fish and Wildlife ServiceKearneysvilleUSA

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