Molecular Biology of Varicella—Zoster Virus
Varicella—zoster virus (VZV) is a human herpesvirus that causes two common clinical conditions: chicken pox (varicella) and shingles (herpes zoster). Virus isolated from patients with either disease is indistinguishable immunologically and biologically from virus isolated from patients with the other disease (reviewed by Taylor-Robinson and Caunt, 1972). Earlier experiments had established that vesicular fluid from patients with herpes zoster could cause varicella when injected into children. For example, Bruusgaard (1932) injected vesicular fluid from 5 herpes zoster patients into the arms of a total of 18 children; 4 of the 18 showed local vesicles and another 4 showed a more generalized vesicle spread. For these reasons, the earlier terms varicella virus and herpes zoster virus have been supplanted by the term varicella—zoster virus.
KeywordsHerpes Simplex Virus Type Herpes Zoster Buoyant Density Herpes Zoster Patient Phosphonoacetic Acid
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