The Biology of Cytomegaloviruses

  • Fred Rapp
Part of the The Viruses book series (VIRS)


The initial isolations of human cytomegaloviruses (HCMVs) occurred in 1956 and 1957 (Rowe et al., 1956; M. G. Smith, 1956; Weller et al., 1957). Many investigators have since isolated CMVs or CMV-like agents from a variety of hosts including monkeys (Black et al., 1963; Ablashi et al., 1972; Asher et al., 1974; Nigida et al., 1979; Rangan and Chaiban, 1980), horses (Plummer and Waterson, 1963; Hsiung et al., 1969), rats (Rabson et al., 1969), squirrels (Diosi and Babusceac, 1970), pigs (Plowright et al., 1976), mice (M. G. Smith, 1954; Kim et al., 1975), guinea pigs (Jackson, 1920; Cole and Kuttner, 1926), and sheep (Hartley and Done, 1963).


Human Cytomegalovirus Cytomegalovirus Infection HCMV Infection MCMV Infection Murine Cytomegalovirus 
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  1. Ablashi, D.V., Martos, L.M., Gilden, R.V., and Hampar, B., 1969, Preparation of rabbit immune serum with neutralizing activity against a simian cytomegalovirus (SA6), J. Immunol. 102: 263.PubMedGoogle Scholar
  2. Ablashi, D.V., Chopra, H.C., and Armstrong, G.R., 1972, A cytomegalovirus isolated from an owl monkey, Lab. Anim. Sci. 22: 190.PubMedGoogle Scholar
  3. Albrecht, T., and Rapp, F., 1973, Malignant transformation of hamster embryo fibroblasts following exposure to ultraviolet-irradiated human cytomegalovirus, Virology 55: 53.PubMedGoogle Scholar
  4. Albrecht, T., and Weller, T.H., 1980, Heterogeneous morphologic features of plaques induced by five strains of human cytomegalovirus, Am. J. Clin. Pathol. 73: 648.PubMedGoogle Scholar
  5. Albrecht, T., Nachtigal, M., St. Jeor, S.C., and Rapp, F., 1976, Induction of cellular DNA synthesis and increased mitotic activity in Syrian hamster embryo cells abortively infected with human cytomegalovirus, J. Gen. Virol. 30: 167.Google Scholar
  6. Albrecht, T., Speelman, D.J., and Li, J.L.H., 1979, Inactivation of human cytomegalovirus by the chemical carcinogen 4-nitroquinoline 1-oxide, J. Gen. Virol. 45: 231.PubMedGoogle Scholar
  7. Albrecht, T., Cavallo, T., Cole N.L., and Graves, K., 1980a, Cytomegalovirus: Development and progression of cytopathic effects in human cell culture, Lab. Invest. 42: 1.PubMedGoogle Scholar
  8. Albrecht, T., Li, M.-L., Cole, N., Downing, E., and Funk, F.D., 1980b, Replication of human cytomegalovirus at supra-optimal temperatures is dependent on the virus strain, multiplicity of infection, and phase of virus replication, J. Gen. Virol. 51: 83.PubMedGoogle Scholar
  9. Araullo-Cruz, T.P., Ho, M., and Armstrong, J.A., 1978, Protective effect of early serum from mice after cytomegalovirus infection, Infect. Immun 21: 840.PubMedGoogle Scholar
  10. Arvin, A.M., Yeager, A.S., and Merigan, T.C., 1976, Effect of leukocyte interferon on urinary excretion of cytomegalovirus by infants, J. Infect. Dis. 133 (Suppl.): A205.PubMedGoogle Scholar
  11. Ashe, W.K., Scherp, H.W., and Fitzgerald, R.J., 1965, Previously unrecognized virus from submaxillary glands of gnotobiotic and conventional rats, J. Bacteriol. 90: 1719.PubMedGoogle Scholar
  12. Asher, D.M., Gibbs, C.J., Lang, D.J., and Gajdusek, D.C., 1974, Persistent shedding of cytomegalovirus in the urine of healthy rhesus monkeys, Proc. Soc. Exp. Biol. Med. 145: 794.PubMedGoogle Scholar
  13. Barabas, G., Wroblewska, Z., and Gilden, D.H., 1980, Growth of murine cytomegalovirus in murine and heterologous brain cell cultures, Arch. Virol. 65: 193.PubMedGoogle Scholar
  14. Berezesky, I.K., Grimley, P.M., Tyrrell, S.A., and Rabson, A.S., 1971, Ultrastructure of a rat cytomegalovirus, Exp. Mol. Pathol. 14: 337.PubMedGoogle Scholar
  15. Betts, R.F., 1979, Cytomegalovirus vaccine in renal transplants, Ann. Intern. Med. 91: 780.PubMedGoogle Scholar
  16. Bia, F.J., Hastings, K., and Hsiung, G.D., 1979, Cytomegalovirus infection in guinea pigs. III. Persistent viruria, blood transmission, and viral interference, J. Infect. Dis. 140: 914.PubMedGoogle Scholar
  17. Bia, F.J., Griffith, B.P., Tarsio, M., and Hsiung, G.D., 1980, Vaccination for the prevention of maternal and fetal infection with guinea pig cytomegalovirus, J. Infect. Dis. 142: 732.PubMedGoogle Scholar
  18. Bixler, G.S., Jr., and Booss, J., 1980, Establishment of immunologic memory concurrent with suppression of the primary immune response during acute cytomegalovirus infection of mice, J. Immunol. 125: 893.PubMedGoogle Scholar
  19. Black, P.H., Hartley, J.W., and Rowe, W.P., 1963, Isolation of a cytomegalovirus from African green monkey, Proc. Soc. Exp. Biol. Med. 112: 601.PubMedGoogle Scholar
  20. Blanton, R.A., and Tevethia, M.J., 1981, Immunoprecipitation of virus-specific immediate-early and early polypeptides from cells lyrically infected with human cytomegalovirus strain AD169, Virology 112: 262.PubMedGoogle Scholar
  21. Boldogh, I., Gönczöl, É., Gärtner, L., and Váczi, G., 1978, Stimulation of host DNA synthesis and induction of early antigens by ultraviolet light irradiated human cytomegalovirus, Arch. Virol. 58: 289.PubMedGoogle Scholar
  22. Booss, J., 1980, Establishment of cytomegaloviral infection in mice: Role of a macrophage-enriched subpopulation, J. Infect. Dis. 141: 466.PubMedGoogle Scholar
  23. Booth, J.C., Beesley, J.E., and Stern, H., 1978, Syncytium formation caused by human cytomegalovirus in human embryonic lung fibroblasts, Arch. Virol. 57: 143.PubMedGoogle Scholar
  24. Brautigam, A.R., and Oldstone, M.B.A., 1980, Replication of murine cytomegalovirus in reproductive tissues, Am. J. Pathol. 98: 213.PubMedGoogle Scholar
  25. Brautigam, A.R., Dutko, F.J., Olding, L.B., and Oldstone, M.B.A., 1979, Pathogenesis of murine cytomegalovirus infection: The macrophage as a permissive cell for cytomegalovirus infection, replication and latency, J. Gen. Virol. 44: 349.PubMedGoogle Scholar
  26. Chantler, J.K., 1978, The use of hypertonicity to selectively inhibit host translation in murine cytomegalovirus-infected cells, Virology 90: 166.PubMedGoogle Scholar
  27. Chantler, J.K., and Hudson, J.B., 1978, Proteins of murine cytomegalovirus: Identification of structural and nonstructural antigens in infected cells, Virology 86: 22.PubMedGoogle Scholar
  28. Chantier, J.K., Misra, V., Hudson, J.B., 1979, Vertical transmission of murine cytomegalovirus, J. Gen. Virol. 42: 621.Google Scholar
  29. Cheung, K.-S., and Lang, D.J., 1977a, Transmission and activation of cytomegalovirus with blood transfusion: A mouse model, J. Infect. Dis. 135: 841.PubMedGoogle Scholar
  30. Cheung, K.-S., and Lang, D.J., 1977b, Detection of latent cytomegalovirus in murine salivary and prostate explant cultures and cells, Infect. Immun. 15: 568.PubMedGoogle Scholar
  31. Cheung, K.-S., Huang, E.-S., and Lang, D., 1980, Murine cytomegalovirus: Detection of latent infection by nucleic acid hybridization technique, Infect. Immun. 27: 851.PubMedGoogle Scholar
  32. Ch’ien, L.T., Cannon, N.J., Whitley, R.J., Diethelm, A.G., Dismukes, W.E., Scott, C.W., Buchanan, R.A., and Alford, C.A., Jr., 1974, Effect of adenine arabinoside on cytomegalovirus infections, J. Infect. Dis. 130: 32.PubMedGoogle Scholar
  33. Choi, Y.C., and Hsiung, G.D., 1978, Cytomegalovirus infection in guinea pigs. II. Trans-placental and horizontal transmission, J. Infect. Dis. 138: 197.PubMedGoogle Scholar
  34. Choi, Y.C., Swack, N.S., and Hsiung, G.D., 1978, Effect of heparin on cytomegalovirus replication, Proc. Soc. Exp. Biol. Med. 157: 569.PubMedGoogle Scholar
  35. Chopra, H.C., Lloyd, B.J., Jr., Ablashi, D.V., and Armstrong, G.R., 1972, Morphologic studies of a cytomegalovirus isolated from an owl monkey, J. Natl. Cancer Inst. 48: 1333.PubMedGoogle Scholar
  36. Colberg-Poley, A.M., Isom, H.C., and Rapp, F., 1979, Reactivation of herpes simplex virus type 2 from a quiescent state by human cytomegalovirus, Proc. Natl. Acad. Sci. U.S.A. 76: 5948.PubMedGoogle Scholar
  37. Cole, R., and Kuttner, A.G., 1926, A filterable virus present in the submaxillary glands of guinea pigs, J. Exp. Med. 44: 855.PubMedGoogle Scholar
  38. Connor, W.S., and Johnson, K.P., 1976, Cytomegalovirus infection in weanling guinea pigs, J. Infect. Dis. 134: 442.PubMedGoogle Scholar
  39. Corner, A.H., Mitchell, D., Julian, R.J., and Meads, E.B., 1964, A generalized disease in piglets associated with the presence of cytomegalic inclusions, J. Comp. Pathol. Ther. 74: 192.Google Scholar
  40. Cross, S.S., Parker, J.C., Rowe, W.P., and Robbins, M.L., 1979, Biology of mouse thymic virus, a herpesvirus of mice, and the antigenic relationship to mouse cytomegalovirus, Infect. Immun. 26: 1186.PubMedGoogle Scholar
  41. Cruz, J.R., Dammin, G.J., and Waner, J.L., 1981, Protective effect of low-dose interferon against neonatal murine cytomegalovirus infection, Infect. Immun. 32: 332.PubMedGoogle Scholar
  42. Davis, G.L., Krawczyk, K.W., and Hawrisiak, M.M., 1979, Age-related neurocytotropism of mouse cytomegalovirus in explanted trigeminal ganglions, Am. J. Pathol. 97: 261.PubMedGoogle Scholar
  43. DeMarchi, J.M., and Kaplan, A.S., 1976, Replication of human cytomegalovirus DNA: Lack of dependence on cell DNA synthesis, J. Virol. 18: 1063.PubMedGoogle Scholar
  44. DeMarchi, J.M., and Kaplan, A.S., 1977a, Physiological state of human embryonic lung cells affects their response to human cytomegalovirus, J. Virol. 23: 126.PubMedGoogle Scholar
  45. DeMarchi, J.M., and Kaplan, A.S., 1977b, The role of defective cytomegalovirus particles in the induction of host cell DNA synthesis, Virology 82: 93.PubMedGoogle Scholar
  46. DeMarchi, J.M., Blankenship, M.L., Brown, G.D., and Kaplan, A.S., 1978, Size and complexity of human cytomegalovirus DNA, Virology 89: 643.PubMedGoogle Scholar
  47. DeMarchi, J.M., Schmidt, C.A., and Kaplan, A.S., 1980, Patterns of transcription of human cytomegalovirus in permissively infected cells, J. Virol. 35: 277.PubMedGoogle Scholar
  48. Diosi, P., and Babusceac, L., 1970, Biological and physicochemical properties of ground squirrel cytomegalovirus, Am. J. Vet. Res. 31: 157.PubMedGoogle Scholar
  49. Diosi, P., Babusceac, L., and Gherman, D., 1972, Cytophagia in cell cultures infected with cytomegalovirus, J. Infect. Dis. 125: 669.PubMedGoogle Scholar
  50. Dowling, J.N., Wu, B.C., Armstrong, J.A., and Ho, M., 1977, Enhancement of murine cytomegalovirus infection during graft-vs.-host reaction, J. Infect. Dis. 135: 990.PubMedGoogle Scholar
  51. Duff, R., and Rapp, F., 1971, Properties of hamster embryo fibroblasts transformed in vitro after exposure to ultraviolet-irradiated herpes simplex virus type 2, J. Virol. 8: 469.PubMedGoogle Scholar
  52. Duff, R., and Rapp, F., 1973, Oncogenic transformation of hamster embryo cells after exposure to inactivated herpes simplex virus type 1, J. Virol. 12: 209.PubMedGoogle Scholar
  53. Duncan, J.R., Ramsey, F.K., and Switzer, W.P., 1965, Electron microscopy of cytomegalic inclusion disease of swine (inclusion body rhinitis), Am. J. Vet. Res. 26: 939.PubMedGoogle Scholar
  54. Dutko, F.J., and Oldstone, M.B.A., 1979, Murine cytomegalovirus infects spermatogenfc cells, Proc. Natl. Acad. Sci. U.S.A. 76: 2988.PubMedGoogle Scholar
  55. Edwards, R.L., 1976, Structural proteins of human cytomegalovirus, Yale J. Biol. Med. 49: 65.PubMedGoogle Scholar
  56. Eizuru, Y., and Minamishima, Y., 1979, Co-variation of pathogenicity and antigenicity in murine cytomegalovirus, Microbiol. Immunol. 23: 559.PubMedGoogle Scholar
  57. Eizuru, Y., Minamishima, Y., Hirano, A., and Kurimura, T., 1978, Replication of mouse cytomegalovirus in thymidine kinase-deficient mouse cells, Microbiol. Immunol. 22: 755.PubMedGoogle Scholar
  58. Elek, S.D., and Stem, H., 1974, Development of a vaccine against mental retardation caused by cytomegalovirus infection in utero, Lancet 1: 1.PubMedGoogle Scholar
  59. Emödi, G., O’Reilly, R., Müller, A., Everson, L.K., Binswanger, U., and Just, M., 1976, Effect of human exogenous leukocyte interferon in cytomegalovirus infections, J. Infect. Dis. 133 (Suppl.): A199.PubMedGoogle Scholar
  60. Estes, J.E., and Huang, E.-S., 1977, Stimulation of cellular thymidine kinases by human cytomegalovirus, J. Virol. 24: 13.PubMedGoogle Scholar
  61. Färber, I., Wutzler, P., Schweizer, H., and Sprössig, M., 1979a, Human cytomegalovirus induced changes in rabbit cells, Arch. Virol. 59: 257.PubMedGoogle Scholar
  62. Färber, I., Wutzler, P., Sprössig, M., and Schweizer, H., 1979b, Determination of antibodies against cytomegalovirus-induced early antigens by using rabbit lung fibroblasts: Brief report, Arch. Virol. 62: 273.PubMedGoogle Scholar
  63. Fiala, M., Honess, R.W., Heiner, D.C., Heine, J.W., Mumane, J., Wallace, R., and Guze, L.B., 1976, Cytomegalovirus proteins. I. Polypeptides of virions and dense bodies, J. Virol. 19: 243.PubMedGoogle Scholar
  64. Fiala, M., Heiner, D.C., Mumane, J., and Guze, L.B., 1978, Cytomegalovirus proteins. II. Polypeptide composition of cytomegalovirus complement-fixing antigen, J. Med. Virol. 2: 39.PubMedGoogle Scholar
  65. Figueroa, M.E., Geder, L., and Rapp, F., 1978a, Replication of herpesviruses in human cells transformed by cytomegalovirus, J. Gen. Virol. 40: 391.PubMedGoogle Scholar
  66. Figueroa, M.E., Geder, L., and Rapp, F., 1978b, Infection of human amnion cells with cytomegalovirus, J. Med. Virol. 2: 369.PubMedGoogle Scholar
  67. Fong, C.K.Y., Bia, F., Hsiung, G.-D., Madore, P., and Chang, P.-W., 1979, Ultrastructural development of guinea pig cytomegalovirus in cultured guinea pig embryo cells, J. Gen. Virol. 42: 127.PubMedGoogle Scholar
  68. Fong, C.K.Y., Bia, F., and Hsiung, G.D., 1980, Ultrastructural development and persistence of guinea pig cytomegalovirus in duct cells of guinea pig submaxillary gland, Arch. Virol. 64: 97.PubMedGoogle Scholar
  69. Frenkel, N., and Roizman, B., 1972, Ribonucleic acid synthesis in cells infected with herpes simplex virus: Control of transcription and of RNA abundance, Proc. Natl. Acad. Sci. U. S.A. 69: 2654.PubMedGoogle Scholar
  70. Furukawa, T., 1979a, Cell cycle-dependent chronic infection of human cytomegalovirus in human osteogenic sarcoma cells, J. Gen. Virol. 45: 81.PubMedGoogle Scholar
  71. Furukawa, T., 1979b, Persistent infection with human cytomegalovirus in a lymphoblastoid cell line, Virology 94: 214.PubMedGoogle Scholar
  72. Furukawa, T., Fioretti, A., and Plotkin, S., 1973, Growth characteristics of cytomegalovirus in human fibroblasts with demonstration of protein synthesis early in viral replication, J. Virol. 11: 991.PubMedGoogle Scholar
  73. Furukawa, T., Homberger, E., Sakuma, S., and Plotkin, S.A., 1975a, Demonstration of immunoglobulin G receptors by human cytomegalovirus, J. Clin. Microbiol. 2: 332.PubMedGoogle Scholar
  74. Furukawa, T., Tanaka, S., and Plotkin, S.A., 1975b, Stimulation of macromolecular synthesis in guinea pig cells by human CMV, Proc. Soc. Exp. Biol. Med. 148: 211.PubMedGoogle Scholar
  75. Furukawa, T., Tanaka, S., and Plotkin, S.A., 1975c, Restricted growth of human cytomegalovirus in UV-irradiated WI-38 human fibroblasts, Proc. Soc. Exp. Biol. Med. 148: 1249.PubMedGoogle Scholar
  76. Furukawa, T., Sakuma, S., and Plotkin, S. A., 1976, Human cytomegalovirus infection of WI-38 cells stimulates mitochondrial DNA synthesis, Nature (London) 262: 414.Google Scholar
  77. Furukawa, T., Jean, J.-H., and Plotkin, S.A., 1978, Enhanced poliovirus replication in cytomegalovirus-infected human fibroblasts, Virology 85: 622.PubMedGoogle Scholar
  78. Furukawa, T., Yoshimura, N., Jean, J.-H., and Plotkin, S.A., 1979, Chronically persistent infection with human cytomegalovirus in human lymphoblasts, J. Infect. Dis. 139: 211.PubMedGoogle Scholar
  79. Gardner, M.B., Officer, J.E., Parker, J., Estes, J., and Rongey, R.W., 1974, Induction of disseminated virulent cytomegalovirus infection by immunosuppression of naturally chronically infected wild mice, Infect. Immun. 10: 966.Google Scholar
  80. Garnett, H.M., 1975, The effect of arginine deprivation on the cytopathogenic effect and replication of human cytomegalovirus, Arch. Virol. 48: 131.PubMedGoogle Scholar
  81. Garnett, H.M., 1979a, The early effects of human cytomegalovirus infection on macromolecular synthesis in human embryonic fibroblasts, Arch. Virol. 60: 147.PubMedGoogle Scholar
  82. Garnett, H.M., 1979b, Early alterations in the morphology of cytomegalovirus-infected human fibroblasts, Intervirology 11: 359.PubMedGoogle Scholar
  83. Garnett, H.M., 1979c, Fusion of cytomegalovirus infected fibroblasts to form multinucleate giant cells, J. Med. Virol. 3: 271.PubMedGoogle Scholar
  84. Geder, L., 1976, Evidence for early nuclear antigens in cytomegalovirus-infected cells, J. Gen. Virol. 32: 315.PubMedGoogle Scholar
  85. Geder, L., and Rapp, F., 1977, Evidence for nuclear antigens in cytomegalovirus-transformed human cells, Nature (London) 265: 184.Google Scholar
  86. Geder, L., Lausch, R., O’Neill, F., and Rapp, F., 1976, Oncogenic transformation of human embryo lung cells by human cytomegalovirus, Science 192: 1134.PubMedGoogle Scholar
  87. Geder, L., Kreider, J., and Rapp, F., 1977, Human cells transformed in vitro by human cytomegalovirus: Tumorigenicity in athymic nude mice, J. Natl. Cancer Inst. 58: 1003.PubMedGoogle Scholar
  88. Geelen, J.L.M.C., Walig, C., Wertheim, P., and van der Noordaa, J., 1978, Human cytomegalovirus DNA. I. Molecular weight and infectivity, J. Virol. 26: 813.PubMedGoogle Scholar
  89. Gergely, L., Czeglédy, J., and Vâczi, L., 1980, Early nuclear antigen as DNA-binding protein in cytomegalovirus-infected cells, Intervirology 13: 352.PubMedGoogle Scholar
  90. Gibson, W., 1981a, Structural and nonstructural proteins of strain Colbum cytomegalovirus, Virology 111: 516.PubMedGoogle Scholar
  91. Gibson, W., 198 lb, Immediate—early proteins of human cytomegalovirus strains AD169, Davis, and Towne differ in electrophoretic mobility, Virology 112: 350.Google Scholar
  92. Glaser, R., Geder, L., St. Jeor, S., Michelson-Fiske, S., and Haguenau, F., 1977, Partial characterization of a herpes-type virus (K9V) derived from Kaposi’s sarcoma, J. Natl. Cancer Inst. 59: 55.Google Scholar
  93. Glasgow, L.A., Hanshaw, J.B., Merigan, T.C., and Petralli, J.K., 1967, Interferon and cytomegalovirus in vivo and in vitro, Proc. Soc. Exp. Biol. Med. 125: 843.PubMedGoogle Scholar
  94. Glazer, J.P., Friedman, H.M., Grossman, R.A., Barker, C.F., Starr, S.E., and Plotkin, S.A., 1978, Cytomegalovirus vaccination and renal transplantation, Lancet 1: 90.PubMedGoogle Scholar
  95. Glazer, J.P., Friedman, H.M., Grossman, R.A., Starr, S.E., Barker, C.F., Perloff, L.J., Huang, E.-S., and Plotkin, S.A., 1979, Live cytomegalovirus vaccination of renal transplant candidates: A preliminary trial, Ann. Intern. Med. 91: 676.PubMedGoogle Scholar
  96. Gönczöl, É., and Vâczi, L., 1973, Cytomegalovirus latency in cultured human cells, J. Gen. Virol. 18: 143.PubMedGoogle Scholar
  97. Gönczöl, É., Boldogh, I., and Váczi, L., 1975, Effect of arginine deficiency on the reproduction of human cytomegalovirus, Acta Microbiol. Acad. Sci. Hung. 22: 263.PubMedGoogle Scholar
  98. Gönczöl, É., Stone, J., and Melero, J.M., 1978, The effect of heat-inactivated murine cytomegalovirus on host DNA synthesis of different cells, J. Gen. Virol. 39: 415.PubMedGoogle Scholar
  99. Goodheart, C.R., and Jaross, L.B., 1963, Human cytomegalovirus: Assay by counting infected cells, Virology 19: 532.PubMedGoogle Scholar
  100. Goodheart, C.R., Filbert, J.E., and McAllister, R.M., 1963, Human cytomegalovirus: Effects of 5-fluorodeoxyuridine on viral synthesis and cytopathology, Virology 21: 530.Google Scholar
  101. Gould, J.J., and Mims, C.A., 1980, Murine cytomegalovirus: Reactivation in pregnancy, J. Gen. Virol. 51: 397.PubMedGoogle Scholar
  102. Griffith, B.P., and Hsiung, G.D., 1980, Cytomegalovirus infection in guinea pigs. IV. Maternal infection at different stages of gestation, J. Infect. Dis. 141: 787.PubMedGoogle Scholar
  103. Gupta, P., and Rapp, F., 1978, Cyclic synthesis of human cytomegalovirus-induced proteins in infected cells, Virology 84: 199.PubMedGoogle Scholar
  104. Gupta, P., St. Jeor, S., and Rapp, F., 1977, Comparison of the polypeptides of several strains of human cytomegalovirus, J. Gen. Virol. 34: 447.Google Scholar
  105. Haines, H.G., Von Essen, R., and Benyesh-Melnick, M., 1971, Preparation of specific antisera to cytomegaloviruses in goats, Proc. Soc. Exp. Biol. Med. 138: 846.PubMedGoogle Scholar
  106. Hamilton, J.D., Fitzwilliam, J.F., Cheung, K.S., Shelburne, J., Lang, D.J., and Amos, D.B., 1978, Viral infection—homograft interactions in a murine model, J. Clin. Invest. 62: 1303.PubMedGoogle Scholar
  107. Hanshaw, J.B., 1974, A cytomegalovirus vaccine?, Am. J. Dis. Child. 128: 141.PubMedGoogle Scholar
  108. Hartley, W.J., and Done, J.T., 1963, Cytomegalic inclusion-body disease in sheep: A report of two cases, J. Comp. Pathol. Ther. 73: 84.Google Scholar
  109. Henson, D., and Neapolitan, C., 1970, Pathogenesis of chronic mouse cytomegalovirus infection in submaxillary glands of C3H mice, Am. J. Pathol. 58: 255.PubMedGoogle Scholar
  110. Henson, D., and Strano, A.J., 1972, Mouse cytomegalovirus: Necrosis of infected and morphologically normal submaxillary gland acinar cells during termination of chronic infection, Am. J. Pathol. 68: 183.PubMedGoogle Scholar
  111. Henson, D., Smith, R.D., and Gehrke, J., 1966, Non-fatal mouse cytomegalovirus hepatitis: Combined morphologic, virologic and immunologic observations, Am. J. Pathol. 49: 871.PubMedGoogle Scholar
  112. Henson, D., Strano, A.J., Slotnik, M., and Goodheart, C., 1972, Mouse cytomegalovirus: Isolation from spleen and lymph nodes of chronically infected mice, Proc. Soc. Exp. Biol. Med. 140: 802.PubMedGoogle Scholar
  113. Hirai, K., and Watanabe, Y., 1976, Induction of a-type DNA polymerases in human cytomegalovirus-infected WI-38 cells, Biochim. Biophys. Acta 447: 328.PubMedGoogle Scholar
  114. Hirai, K., Maeda, F., and Watanabe, Y., 1977, Expression of early virus functions in human cytomegalovirus infected HEL cells: Effect of ultraviolet light-irradiation of the virus, J. Gen. Virol. 38: 121.Google Scholar
  115. Holmes, A.R., Rasmussen, L., and Merigan, T.C., 1978, Factors affecting the interferon sensitivity of human cytomegalovirus, Intervirology 9: 48.PubMedGoogle Scholar
  116. Howard, R.J., and Najarian, J.S., 1974, Cytomegalovirus-induced immune suppression. I. Humoral immunity, Clin. Exp. Immunol. 18: 109.PubMedGoogle Scholar
  117. Howard, R.J., Miller, J., and Najarian, J.S., 1974, Cytomegalovirus-induced immune suppression. II. Cell-mediated immunity, Clin. Exp. Immunol. 18: 119.PubMedGoogle Scholar
  118. Howard, R.J., Mattsson, D.M., Seidel, M.V., and Balfour, H.H., Jr., 1978, Cell-mediated immunity to murine cytomegalovirus, J. Infect. Dis. 138: 597.Google Scholar
  119. Howard, R.J., Mattsson, D.M., and Balfour, H.H., Jr., 1979, Effect of immunosuppression on humoral and cell-mediated immunity to murine cytomegalovirus, Proc. Soc. Exp. Biol. Med. 161: 341.PubMedGoogle Scholar
  120. Hsiung, G.D., Fischman, H.R., Fong, C.K.Y., and Green, R.H., 1969, Characterization of a cytomegalo-like virus isolated from spontaneously degenerated equine kidney cell culture, Proc. Soc. Exp. Biol. Med. 130: 80.PubMedGoogle Scholar
  121. Hsiung, G.D., Tenser, R.B., and Fong, C.K.Y., 1976, Comparison of guinea pig cytomegalovirus and guinea pig herpes-like virus: Growth characteristics and antigenic relationship, Infect. Immun. 13: 926.PubMedGoogle Scholar
  122. Hsiung, G.D., Choi, Y.C., and Bia, F., 1978, Cytomegalovirus infection in guinea pigs. I. Viremia during acute primary and chronic persistent infection, J. Infect. Dis. 138: 191.PubMedGoogle Scholar
  123. Hsiung, G.D., Bia, F.J., and Fong, C.K.Y., 1980, Viruses of guinea pigs: Considerations for biomedical research, Microbiol. Rev. 44: 468.PubMedGoogle Scholar
  124. Huang, E.-S., 1975a, Human cytomegalovirus. III. Virus-induced DNA polymerase, J. Virol. 16: 298.PubMedGoogle Scholar
  125. Huang, E.-S., 1975b, Human cytomegalovirus. IV. Specific inhibition of virus-induced DNA polymerase activity and viral DNA replication by phosphonoacetic acid, J. Virol. 16: 1560.PubMedGoogle Scholar
  126. Huang, E.-S., and Pagano, J.S., 1974, Human cytomegalovirus. II. Lack of relatedness to DNA of herpes simplex I and II, Epstein-Barr virus, and nonhuman strains of cytomegalovirus, J. Virol. 13: 642.PubMedGoogle Scholar
  127. Huang, E.-S., Chen, S.-T., and Pagano, J.S., 1973, Human cytomegalovirus. I. Purification and characterization of viral DNA, J. Virol. 12: 1473.PubMedGoogle Scholar
  128. Huang, E.-S., Kilpatrick, B.A., Huang, Y.-T., and Pagano, J.S., 1976, Detection of human cytomegalovirus and analysis of strain variation, Yale J. Biol. Med. 49: 29.PubMedGoogle Scholar
  129. Huang, E.-S., Kilpatrick, B., Lakeman, A., and Alford, C.A., 1978a, Genetic analysis of a cytomegalovirus-like agent isolated from human brain, J. Virol. 26: 718.PubMedGoogle Scholar
  130. Huang, E.-S., Leyritz, M., Menezes, J., and Joncas, J.H., 1978b, Persistence of both human cytomegalovirus and Epstein—Barr virus genomes in two human lymphoblastoid cell lines, J. Gen. Virol. 40: 519.PubMedGoogle Scholar
  131. Huang, E.-S., Alford, C.A., Reynolds, D.W., Stagno, S., and Pass, R.F., 1980, Molecular epidemiology of cytomegalovirus infections in women and their infants, N. Engl. J. Med. 303: 958.PubMedGoogle Scholar
  132. Huang, Y.-T., Huang, E.-S., and Pagano, J.S., 1974, Antisera to human cytomegaloviruses prepared in the guinea pig: Specific immunofluorescence and complement fixation tests, J. Immunol. 112: 528.PubMedGoogle Scholar
  133. Hudson, J.B., 1979, The murine cytomegalovirus as a model for the study of viral pathogenesis and persistent infections, Arch. Virol. 62: 1.PubMedGoogle Scholar
  134. Hudson, J.B., 1980, The problem of host DNA synthesis in murine cytomegalovirus-infected cells, Virology 101: 545.PubMedGoogle Scholar
  135. Hudson, J.B., Misra, V., and Mosmann, T.R., 1976a, Properties of the multicapsid virions of murine cytomegalovirus, Virology 72: 224.PubMedGoogle Scholar
  136. Hudson, J.B., Misra, V., and Mosmann, T.R., 1976b, Cytomegalovirus infectivity: Analysis of the phenomenon of centrifugal enhancement of infectivity, Virology 72: 235.PubMedGoogle Scholar
  137. Hudson, J.B., Loh, L., Misra, V., Judd, B., and Suzuki, J., 1977, Multiple interactions between murine cytomegalovirus and lymphoid cells in vitro, J. Gen. Virol. 38: 149.Google Scholar
  138. Hudson, J.B., Chantler, J.K., Loh, L., Misra, V., and Muller, M.T., 1979, Model systems for analysis of latent cytomegalovirus infections, Can. J. Microbiol. 25: 245.PubMedGoogle Scholar
  139. Ihara, S., Hirai, K., and Watanabe, Y., 1978, Temperature-sensitive mutants of human cytomegalovirus: Isolation and partial characterization of DNA-minus mutants, Virology 84: 218.PubMedGoogle Scholar
  140. Ihara, S., Saito, S., and Watanabe, Y., 1980, An early function of human cytomegalovirus required for structural integrity of the virus-induced nuclear inclusion, Microbiol. Immunol. 24: 891.PubMedGoogle Scholar
  141. Ito, M., Girvin, L., and Barron, A.L., 1978, Inactivation of human cytomegalovirus by phytohemagglutinin, Arch. Virol. 57: 97.PubMedGoogle Scholar
  142. Jackson, L., 1920, An intracellular protozoan parasite of the ducts of the salivary glands of the guinea pig, J. Infect. Dis. 26: 347.Google Scholar
  143. Jean, J.-H., Yoshimura, N., Furukawa, T., and Plotkin, S.A., 1978, Intracellular forms of the parental human cytomegalovirus genome at early stages of the infective process, Virology 86: 281.PubMedGoogle Scholar
  144. Johnson, K.P., 1969, Mouse cytomegalovirus: Placental infection, J. Infect. Dis. 120: 445.PubMedGoogle Scholar
  145. Johnson, K.P., and Connor, W.S., 1979, Guinea pig cytomegalovirus: Transplacental transmission, Arch. Virol. 59: 263.PubMedGoogle Scholar
  146. Joncas, J.H., Menezes, J., and Huang, E.-S., 1975, Persistence of CMV genome in lymphoid cells after congenital infection, Nature (London) 258: 432.Google Scholar
  147. Jordan, M.C., 1978, Interstitial pneumonia and subclinical infection after intranasal inoculation of murine cytomegalovirus, Infect. Immun. 21: 275.PubMedGoogle Scholar
  148. Jordan, M.C., 1980, Adverse effects of cytomegalovirus vaccine in mice, J. Clin. Invest. 65: 798.PubMedGoogle Scholar
  149. Jordan, M.C., Shanley, J.C., and Stevens, J.G., 1977, Immunosuppression reactivates and disseminates latent murine cytomegalovirus, J. Gen. Virol. 37: 419.PubMedGoogle Scholar
  150. Kamata, T., Tanaka, S., and Watanabe, Y., 1978, Human cytomegalovirus-induced chromatin factors responsible for changes in template activity and structure of infected cell chromatin, Virology 90: 197.PubMedGoogle Scholar
  151. Kamata, T., Tanaka, S., and Watanabe, Y., 1979, Characterization of the human cytomegalovirus-induced chromatin factor responsible for activation of host cell chromatin template, Virology 97: 224.PubMedGoogle Scholar
  152. Kierszenbaum, A.L., and Huang, E.-S., 1978, Chromatin pattern consisting of repeating bipartite structures in WI-38 cells infected with human cytomegalovirus, J. Virol. 28: 661.PubMedGoogle Scholar
  153. Kilham, L., and Margolis, G., 1975, Encephalitis in suckling rats induced with rat cytomegalovirus, Lab. Invest. 33: 200.PubMedGoogle Scholar
  154. Kilpatrick, B.A., and Huang, E.-S., 1977, Human cytomegalovirus genome: Partial denaturation map and organization of genome sequences, J. Virol. 24: 261.PubMedGoogle Scholar
  155. Kilpatrick, B.A., Huang, E.-S., and Pagano, J.S., 1976, Analysis of cytomegalovirus genomes with restriction endonucleases HinD III and EcoR-1, J. Virol. 18: 1095.PubMedGoogle Scholar
  156. Kim, K.S., and Carp, R.I., 1971, Growth of murine cytomegalovirus in various cell lines, J. Virol. 7: 720.PubMedGoogle Scholar
  157. Kim, K.S., and Carp, R.I., 1972, Abortive infection of human diploid cells by murine cytomegalovirus, Infect. Immun. 6: 793.PubMedGoogle Scholar
  158. Kim, K.S., and Carp, R.I., 1973, Effect of proteolytic enzymes on the infectivity of a number of herpesviruses, J. Infect. Dis. 128: 788.PubMedGoogle Scholar
  159. Kim, K.S., Sapienza, V., and Carp, R.I., 1975, Comparative characteristics of three cytomegaloviruses from rodents, Am. J. Vet. Res. 36: 1495.PubMedGoogle Scholar
  160. Kim, K.S., Sapienza, V.J., Carp, R.I., and Moon, H.M., 1976, Analysis of structural proteins of purified murine cytomegalovirus, J. Virol. 17: 906.PubMedGoogle Scholar
  161. Krugman, R.D., and Goodheart, C.R., 1964, Human cytomegalovirus: Thermal inactivation, Virology 23: 290.PubMedGoogle Scholar
  162. Kumar, M.L., and Nankervis, G.A., 1978, Experimental congenital infection with cytomegalovirus: A guinea pig model, J. Infect. Dis. 138: 650.PubMedGoogle Scholar
  163. Lakeman, A.D., and Osborn, J.E., 1979, Size of infectious DNA from human and murine cytomegaloviruses, J. Virol. 30: 414.PubMedGoogle Scholar
  164. Landini, M.P., Musiani, M., Zerbini, M., Falcieri, E., La Placa, M., 1979, Inhibition of a complete replication cycle of human cytomegalovirus in actinomycin pre-treated cells, J. Gen. Virol. 42: 423.PubMedGoogle Scholar
  165. Loh, L., and Hudson, J.B., 1979, Interaction of murine cytomegalovirus with separated populations of spleen cells, Infect. Immun. 26: 853.PubMedGoogle Scholar
  166. Loh, Ì., and Hudson, J.B., 1980, Immunosuppressive effect of murine cytomegalovirus, Infect. Immun. 27: 54.PubMedGoogle Scholar
  167. Lüleci, G., Sakizlí, M., and Günalp, A., 1980, Selective chromosomal damage caused by human cytomegalovirus, Acta Virol. 24: 341.PubMedGoogle Scholar
  168. Manischewitz, J.E., and Quinnan, G.V., Jr., 1980, Antivirus antibody-dependent cell-mediated cytotoxicity during murine cytomegalovirus infection, Infect. Immun. 29: 1050.PubMedGoogle Scholar
  169. Mäntyjärvi, R.A., Selgrade, M.K., Collier, A.M., Hu, S.-C., Pagano, J.S., 1977, Murine cytomegalovirus infection of epithelial cells in mouse tracheal ring organ culture, J. Infect. Dis. 136: 444.PubMedGoogle Scholar
  170. Margolis, G., and Kilham, L., 1976, Neuronal parasitism and cell fusion in mouse cytomegalovirus encephalitis, Exp. Mol. Pathol. 25: 20.PubMedGoogle Scholar
  171. Mattsson, D.M., Howard, R.J., and Balfour, H.H., Jr., 1980, Immediate loss of cell-mediated immunity to murine cytomegalovirus upon treatment with immunosuppressive agents, Infect. Immun 30: 700.PubMedGoogle Scholar
  172. Mayo, D.R., and Rapp, F., 1980, Acute cytomegalovirus infections in leukemic mice, Infect. Immun. 29: 311.PubMedGoogle Scholar
  173. Mayo, D., Armstrong, J.A., and Ho, M., 1978, Activation of latent murine cytomegalovirus infection: Cocultivation, cell transfer, and the effect of immunosuppression, J. Infect. Dis. 138: 890.PubMedGoogle Scholar
  174. McAllister, R.M., Straw, R.M., Filbert, J.E., and Goodheart, C.R., 1963, Human cytomegalovirus: Cytochemical observations of intracellular lesion development correlated with viral synthesis and release, Virology 19: 521.Google Scholar
  175. McAllister, R.M., Filbert, J.E., and Goodheart, C.R., 1967, Human cytomegalovirus: Studies on the mechanism of viral cytopathology and inclusion body formation, Proc. Soc. Exp. Biol. Med. 124: 932.PubMedGoogle Scholar
  176. McGavran, M.H., and Smith, M.G., 1965, Ultrastructural, cytochemical and microchemical observations on cytomegalovirus (salivary gland virus) infection of human cells in tissue culture, Exp. Mol. Pathol. 4: 1.Google Scholar
  177. Medearis, D.N., Jr., 1964a, Mouse cytomegalovirus infection. II. Observations during prolonged infections, Am. J. Hyg. 80: 103.PubMedGoogle Scholar
  178. Medearis, D.N., Jr., 1964b, Mouse cytomegalovirus infection. III. Attempts to produce intrauterine infections, Am. J. Hyg. 80: 113.PubMedGoogle Scholar
  179. Medearis, D.N., Jr., and Prokay, S.L., 1978, Effect of immunization of mothers on cytomegalovirus infection in suckling mice, Proc. Soc. Exp. Biol. Med. 157: 523.PubMedGoogle Scholar
  180. Meggs, P.D., and Beer, A.D., 1979, In vitro stimulation of human colostral lymphocytes by cytomegalovirus, Am. J. Obstet. Gynecol. 133: 703.Google Scholar
  181. Michelson, S., Horodniceanu, F., Kress, M., and Tardy-Panit, M., 1979, Human cytomegalovirus-induced immediate early antigens: Analysis in sodium dodecyl sulfate—polyacrylamide gel electrophoresis after immunoprecipitation, J. Virol. 32: 259.PubMedGoogle Scholar
  182. Michelson-Fiske, S., Arnoult, J., and Febvre, H., 1975, Cytomegalovirus infection of human lung epithelial cells in vitro, Intervirology 5: 354.PubMedGoogle Scholar
  183. Michelson-Fiske, S., Horodniceanu, F., and Guillon, J.-C., 1977, Immediate early antigens in human cytomegalovirus infected cells, Nature (London) 270: 615.Google Scholar
  184. Middlekamp, J.N., Patrizi, G., and Reed, C.A., 1967, Light and electron microscopic studies of the guinea pig cytomegalovirus, J. Ultrastruct. Res. 18: 85.Google Scholar
  185. Miller, R.L., Iltis, J.P., and Rapp, F., 1977, Differential effect of arabinofuranosylthymine on the replication of human herpesviruses, J. Virol. 23: 679.PubMedGoogle Scholar
  186. Mims, C.A., and Gould, J., 1978, The role of macrophages in mice infected with murine cytomegalovirus, J. Gen. Virol. 41: 143.PubMedGoogle Scholar
  187. Mims, C.A., and Gould, J., 1979, Infection of salivary glands, kidneys, adrenals, ovaries and epithelia by murine cytomegalovirus, J. Med. Microbiol. 12: 113.PubMedGoogle Scholar
  188. Minamishima, Y., Graham, B.J., and Benyesh-Melnick, M., 1971, Neutralizing antibodies to cytomegaloviruses in normal simian and human sera, Infect. Immun. 4: 368.PubMedGoogle Scholar
  189. Minamishima, Y., Eizuru, Y., Yoshida, A., and Fukunishi, R., 1978, Murine model for immunoprophylaxis of cytomegalovirus infection. I. Efficacy of immunization, Microbiol. Immunol. 22: 693.PubMedGoogle Scholar
  190. Misra, V., and Hudson, J.B., 1980, Minor base sequence differences between the genomes of two strains of murine cytomegalovirus differing in virulence, Arch. Virol. 64: 1.PubMedGoogle Scholar
  191. Misra, V., Muller, M.T., and Hudson, J.B., 1977, The enumeration of viral genomes in murine cytomegalovirus-infected cells, Virology 83: 458.PubMedGoogle Scholar
  192. Misra, V., Muller, M.T., Chantler, J.K., and Hudson, J.B., 1978, Regulation of murine cytomegalovirus gene expression. I. Transcription during productive infection, J. Virol. 27: 263.PubMedGoogle Scholar
  193. Mocarski, E.S., and Stinski, M.F., 1979, Persistence of the cytomegalovirus genome in human cells, J. Virol. 31: 761.PubMedGoogle Scholar
  194. Moon, H.M., Sapienza, V.J., Carp, R.I., and Kim, K.S., 1976, DNA synthesis in mouse embryo fibroblast cells infected with murine cytomegalovirus, Virology 75: 376.PubMedGoogle Scholar
  195. Moon, H.M., Sapienza, V.J., Carp, R.I., and Kim, K.S., 1979, Murine cytomegalovirus-induced protein synthesis, J. Gen. Virol. 42: 159.PubMedGoogle Scholar
  196. Mosmann, T.R., and Hudson, J.B., 1973, Some properties of the genome of murine cytomegalovirus (MCV), Virology 54: 135.PubMedGoogle Scholar
  197. Mosmann, T.R., and Hudson, J.B., 1974, Structural and functional heterogeneity of the murine cytomegalovirus genome, Virology 62: 175.PubMedGoogle Scholar
  198. Muchmore, E., 1971, Possible cytomegalovirus infection in man following chimpanzee bite, Lab. Anim. Sci. 21: 1080.PubMedGoogle Scholar
  199. Muller, M.T., and Hudson, J.B., 1977a, Cell cycle dependency of murine cytomegalovirus replication in synchronized 3T3 cells, J. Virol. 22: 267.PubMedGoogle Scholar
  200. Muller, M.T., and Hudson, J.B., 1977b, Thymidine kinase activity in mouse 3T3 cells infected by murine cytomegalovirus (MCV), Virology 80: 430.PubMedGoogle Scholar
  201. Muller, M.T., and Hudson, J.B., 1978, Murine cytomegalovirus DNA synthesis in nuclear monolayers, Virology 88: 371.PubMedGoogle Scholar
  202. Muller, M., Misra, V., Chantler, J.K., and Hudson, J.B., 1978, Murine cytomegalovirus gene expression during nonproductive infection in Go-phase 3T3 cells, Virology 90: 279.PubMedGoogle Scholar
  203. Musiani, M., Zerbini, M., Landini, M.P., and La Placa, M., 1979, Preliminary evidence that cytomegalovirus-induced immediate early antigens are DNA-binding proteins, Microbiologica 2: 281.Google Scholar
  204. Nedrud, J.G., Collier, A.M., and Pagano, J.S., 1979, Cellular basis for susceptibility to mouse cytomegalovirus: Evidence from tracheal organ culture, J. Gen. Virol. 45: 737.PubMedGoogle Scholar
  205. Neff, B.J., Weibel, R.E., Buynak, E.B., McLean, A.A., and Hilleman, M.R., 1979, Clinical and laboratory studies of live cytomegalovirus vaccine Ad-169, Proc. Soc. Exp. Biol. Med. 160: 32.PubMedGoogle Scholar
  206. Neighbour, P.A., 1978, Studies on the susceptibility of the mouse preimplantation embryo to infection with cytomegalovirus, J. Reprod. Fertil. 54: 15.PubMedGoogle Scholar
  207. Neighbour, P.A., and Fraser, L.R., 1978, Murine cytomegalovirus and fertility: Potential sexual transmission and the effect of this virus on fertilization in vitro, Fertil. Steril. 30: 216.PubMedGoogle Scholar
  208. Nigida, S.M., Falk, L.A., Wolfe, L.G., Deinhardt, F., Lakeman, A., and Alford, C.A., 1975, Experimental infection of marmosets with a cytomegalovirus of human origin, J. Infect. Dis. 132: 582.PubMedGoogle Scholar
  209. Nigida, S.M., Falk, L.A., Wolfe, L.G., and Deinhardt, F:, 1979, Isolation of a cytomegalovirus from salivary glands of white-lipped marmosets (Saguinus fuscicollis), Lab. Anim. Sci. 29: 53.Google Scholar
  210. Nishiyama, Y., and Rapp, F., 1980, Enhanced survival of ultraviolet-irradiated herpes simplex virus in human cytomegalovirus-infected cells, Virology 100: 189.PubMedGoogle Scholar
  211. Oie, H.K., Easton, J.M., Ablashi, D.V., and Baron, S., 1975, Murine cytomegalovirus: Induction of and sensitivity to interferon in vitro, Infect. Immun. 12: 1012.PubMedGoogle Scholar
  212. Olding, L.B., Jensen, F.C., and Oldstone, M.B.A., 1975, Pathogenesis of cytomegalovirus infection. I. Activation of virus from bone marrow-derived lymphocytes by in vitro allogenic reaction, J. Exp. Med. 141: 561.PubMedGoogle Scholar
  213. Olding, L.B., Kingsbury, D.T., and Oldstone, M.B.A., 1976, Pathogenesis of cytomegalovirus infection: Distribution of viral products, immune complexes and autoimmunity during latent murine infection, J. Gen. Virol. 33: 267.PubMedGoogle Scholar
  214. Oldstone, M.B.A., Olding, L.B., and Brautigam, A.R., 1977, Adventures in latency and reactivation of cytomegalovirus: Facts and fantasies, in: Excerpta Medica International Congress Series No. 423, Transplantation and Clinical Immunology, Volume IX, Proceedings of the Ninth International Course, Lyon, France (June 6–8, 1977 ), p. 11.Google Scholar
  215. Osbom, J.E., and Walker, D.L., 1968, Enhancement of infectivity of murine cytomegalovirus in vitro by centrifugal inoculation, J. Virol. 2: 853.Google Scholar
  216. Osborn, J.E., Blazkovec, A.H., and Walker, D.L., 1968, Immunosuppression during acute murine cytomegalovirus infection, J. Immunol. 100: 835.PubMedGoogle Scholar
  217. Overall, J.C., Jr., Kern, E.R., and Glasgow, L.A., 1976, Effective antiviral chemotherapy in cytomegalovirus infection of mice, J. Infect. Dis. 133 (Suppl.): A237.Google Scholar
  218. Patrizi, G., Middlekamp, J.N., and Reed, C.A., 1967, Reduplication of nuclear membranes in tissue-culture cells infected with guinea-pig cytomegalovirus, Am. J. Pathol. 50: 779.PubMedGoogle Scholar
  219. Phillips, C.F., 1979, Cytomegalovirus vaccine: A realistic appraisal, Hosp. Pract., p. 75.Google Scholar
  220. Plotkin, S.A., 1979, Vaccination against herpes group viruses, in particular, cytomegalovirus, Monogr. Paediatr. 11: 58.PubMedGoogle Scholar
  221. Plotkin, S.A., Furukawa, T., Zygraich, N., and Huygelen, C., 1975, Candidate cytomegalovirus strain for human vaccination, Infect. Immun 12: 521.PubMedGoogle Scholar
  222. Plowright, W., Edington, N., and Watt, R.G., 1976, The behaviour of porcine cytomegalovirus in commercial pig herds, J. Hyg. 76: 125.Google Scholar
  223. Plummer, G., and Goodheart, C.R., 1974, Growth of murine cytomegalovirus in a heterologous cell system and its enhancement by 5-iodo-2’-deoxyuridine, Infect. Immun. 10: 251.PubMedGoogle Scholar
  224. Plummer, G., and Lewis, B., 1965, Thermoinactivation of herpes simplex virus and cytomegalovirus, J. Bacteriol. 89: 671.PubMedGoogle Scholar
  225. Plummer, G., and Waterson, A.P., 1963, Equine herpes viruses, Virology 19: 412.PubMedGoogle Scholar
  226. Pritchett, R.F., 1980, DNA nucleotide sequence heterogeneity between the Towne and AD 169 strains of cytomegalovirus, J. Virol. 36: 152.PubMedGoogle Scholar
  227. Rabson, A.S., Edgcomb, J.H., Legallais, F.Y., and Tyrrell, S.A., 1969, Isolation and growth of rat cytomegalovirus in vitro, Proc. Soc.. Exp. Biol. Med. 131: 923.PubMedGoogle Scholar
  228. Radsak, K., and Schmitz, B., 1980, Unimpaired histone synthesis in human fibroblasts infected by human cytomegalovirus, Med. Microbiol. Immunol. 168: 63.PubMedGoogle Scholar
  229. Radsak, K., Furukawa, T., and Plotkin, St., 1980, DNA synthesis in chromatin preparations from human fibroblasts infected by cytomegalovirus, Arch. Virol. 65: 45.PubMedGoogle Scholar
  230. Ramirez, M.L., Virmani, M., Garon, C., and Rosenthal, L.J., 1979, Defective virions of human cytomegalovirus, Virology 96: 311.PubMedGoogle Scholar
  231. Rangan, S.R.S., and Chaiban, J., 1980, Isolation and characterization of a cytomegalovirus from the salivary gland of a squirrel monkey (Saimiri sciureus), Lab. Anim Sci. 30: 532.PubMedGoogle Scholar
  232. Rapp, F., and Geder, L., 1978, Persistence and transformation by human cytomegalovirus, in: Persistent Viruses, ICN—UCLA Symposia on Molecular and Cellular Biology ( J.G. Stevens, G.J. Todaro, and C.F. Fox, eds.), pp. 767–785, Academic Press, New York.Google Scholar
  233. Rapp, F., and McCarthy, B.A., 1979, The oncogenic properties of human cytomegalovirus, in: Antiviral Mechanisms in the Control of Neoplasia Vol. 20 ( P. Chandra, ed.), pp. 263–283, Plenum Press, New York.Google Scholar
  234. Rapp, F., Rasmussen, L.E., and Benyesh-Melnick, M., 1963, The immunofluorescent focus technique in studying the replication of cytomegalovirus, J. Immunol. 91: 709.PubMedGoogle Scholar
  235. Rapp, F., Geder, L., Murasko, D., Lausch, R., Ladda, R., Huang, E.-S., and Webber, M.M., 1975, Long-term persistence of cytomegalovirus genome in cultured human cells of prostatic origin, J. Virol. 16: 982.PubMedGoogle Scholar
  236. Reynolds, D.W., 1978, Development of early nuclear antigen in cytomegalovirus infected cells in the presence of RNA and protein synthesis inhibitors, J. Gen. Virol. 40: 475.PubMedGoogle Scholar
  237. Rinaldo, C.R., Jr., Richter, B.S., Black, P.H., Callery, R., Chess, L., and Hirsch, M.S., 1978, Replication of herpes simplex virus and cytomegalovirus in human leukocytes, J. Immunol. 120: 130.PubMedGoogle Scholar
  238. Rowe, W.P., Hartley, J.W., Waterman, S., Turner, H.C., and Huebner, R.J., 1956, Cytopathic agent resembling human salivary gland virus recovered from tissue cultures of human adenoids, Proc. Soc. Exp. Biol. Med. 92: 418.PubMedGoogle Scholar
  239. Ruebner, B.H., Miyai, K., Slusser, R.J., Wedemeyer, P., and Medearis, D.N., Jr., 1964, Mouse cytomegalovirus infection: An electron microscopic study of hepatic parenchymal cells, Am. J. Pathol. 44: 799.PubMedGoogle Scholar
  240. Ruebner, B.H., Hirano, T., Slusser, R., Osborn, J., and Medearis, D.N., Jr., 1966, Cytomegalovirus infection: Viral ultrastructure with particular reference to the relationship of lysosomes to cytoplasmic inclusions, Am. J. Pathol. 48: 971.PubMedGoogle Scholar
  241. Rytel, M.W., and Hooks, J.J., 1977, Induction of immune interferon by murine cytomegalovirus, Proc. Soc. Exp. Biol. Med. 155: 611.Google Scholar
  242. St. Jeor, S.C., and Hutt, R., 1977, Cell DNA replication as a function in the synthesis of human cytomegalovirus, J. Gen. Virol. 37: 65.Google Scholar
  243. St. Jeor, S., and Rapp, F., 1973, Cytomegalovirus: Conversion of nonpermissive cells to a permissive state for virus replication, Science 181: 1060.Google Scholar
  244. St. Jeor, S., and Weisser, A., 1977, Persistence of cytomegalovirus in human lymphoblasts and peripheral leukocyte cultures, Infect. Immun. 15: 402.Google Scholar
  245. St. Jeor, S.C., Albrecht, T.B., Funk, F.D., and Rapp, F., 1974, Stimulation of cellular DNA synthesis by human cytomegalovirus, J. Virol. 13: 353.Google Scholar
  246. Sarov, I., and Abady, I., 1975, The morphogenesis of human cytomegalovirus: Isolation and polypeptide characterization of cytomegalovirions and dense bodies, Virology 66: 464.PubMedGoogle Scholar
  247. Sarov, I., and Friedman, A., 1976, Electron microscopy of human cytomegalovirus DNA, Arch. Virol. 50: 343.PubMedGoogle Scholar
  248. Sarov, I., Larson, A.M., Heron, I., and Anderson, H.K., 1978, Stimulation of human lymphocytes by cytomegalovirions and dense bodies, Med. Microbiol. Immunol. 166: 81.PubMedGoogle Scholar
  249. Schirm, J., Roenhorst, H.W., and The, T.H., 1980, Comparison of in vitro lymphocyte proliferations induced by cytomegalovirus-infected human fibroblasts and cell-free cytomegalovirus, Infect. Immun. 30: 621.PubMedGoogle Scholar
  250. Schleupner, C.J., Olsen, G.A., and Glasgow, L.A., 1979, Activation of reticuloendothelial cells following infection with murine cytomegalovirus, J. Infect. Dis. 139: 641.PubMedGoogle Scholar
  251. Schmitz, H., Doerr, H.W., and Orbrig, M., 1975, Envelope and nucleocapsid antigens of cytomegalovirus (CMV), Med. Microbiol Immunol. 161: 155.PubMedGoogle Scholar
  252. Schnitzer, T.J., and Gönczöl, É., 1979, Phenotypic mixing between murine oncoviruses and murine cytomegalovirus, J. Gen. Virol. 43: 691.PubMedGoogle Scholar
  253. Schwartz, J.N., Daniels, C.A., and Klintworth, G.K., 1975, Lymphoid cell necrosis, thymic atrophy, and growth retardation in newborn mice inoculated with murine cytomegalovirus, Am. J. Pathol. 79: 509.PubMedGoogle Scholar
  254. Severi, B., Landini, M.P., Musiani, M., and Zerbini, M., 1979, A study of the passage of human cytomegalovirus from the nucleus to the cytoplasm, Microbiologica 2: 265.Google Scholar
  255. Shanley, J.D., and Pesanti, E.L., 1980, Replication of murine cytomegalovirus in lung macrophages: Effect on phagocytosis of bacteria, Infect. Immun 29: 1152.PubMedGoogle Scholar
  256. Shanley, J.D., Jordan, M.C., Cook, M.L., and Stevens, J.G., 1979, Pathogenesis of reactivated latent murine cytomegalovirus infection, Am. J. Pathol. 95: 67.PubMedGoogle Scholar
  257. Smith, J.D., and De Harven, E., 1973, Herpes simplex virus and human cytomegalovirus replication in WI-38 cells. I. Sequence of viral replication, J. Virol. 12: 919.PubMedGoogle Scholar
  258. Smith, J.D., and De Harven, E., 1974, Herpes simplex virus and human cytomegalovirus replication in WI-38 cells. II. An ultrastructural study of viral penetration, J. Virol. 14: 945.PubMedGoogle Scholar
  259. Smith, J.D., and De Harven, E., 1978, Herpes simplex virus and human cytomegalovirus replication in WI-38 cells. III. Cytochemical localization of lysosomal enzymes in infected cells, J. Virol. 26: 102.PubMedGoogle Scholar
  260. Smith, J.D., and De Harven, E., 1979, Localization of arginine-rich protein in cytomegalovirus dense bodies using phenanthrenequinone fluorescence, Virology 96: 335.PubMedGoogle Scholar
  261. Smith, K.O., and Rasmussen, L., 1963, Morphology of cytomegalovirus (salivary gland virus), J. Bacteriol. 85: 1319.PubMedGoogle Scholar
  262. Smith, K.O., Thiel, J.F., Newman, J.T., Harvey, E., Trousdale, M.D., Gehle, W.D., and Clark, G., 1969, Cytomegaloviruses as common adventitious contaminants in primary African green monkey kidney cell cultures, J. Natl. Cancer Inst. 42: 489.PubMedGoogle Scholar
  263. Smith, M.G., 1954, Propagation of salivary gland virus of the mouse in tissue cultures, Proc. Soc. Exp. Biol. Med. 86: 435.PubMedGoogle Scholar
  264. Smith, M.G., 1956, Propagation in tissue cultures of a cytopathogenic virus from human salivary gland virus (SGV) disease, Proc. Soc. Exp. Biol. Med. 92: 424.PubMedGoogle Scholar
  265. Smith, R.D., and Wehner, R.W., 1980, Acute cytomegalovirus glomerulonephritis, Lab. Invest. 43: 278.PubMedGoogle Scholar
  266. Spear, P.G., and Roizman, B., 1972, Proteins specified by herpes simplex virus. V. Purification and structural proteins of the herpesvirion, J. Virol. 9: 143.PubMedGoogle Scholar
  267. Stinski, M.F., 1976, Human cytomegalovirus: Glycoproteins associated with virions and dense bodies, J. Virol. 19: 594.PubMedGoogle Scholar
  268. Stinski, M.F., 1977, Synthesis of proteins and glycoproteins in cells infected with human cytomegalovirus, J. Virol. 23: 751.PubMedGoogle Scholar
  269. Stinski, M.F., 1978, Sequence of protein synthesis in cells infected by human cytomegalovirus: Early and late virus-induced polypeptides, J. Virol. 26: 686.PubMedGoogle Scholar
  270. Stinski, M.F., Mocarski, E.S., and Thomsen, D.R., 1979a, DNA of human cytomegalovirus: Size heterogeneity and defectiveness resulting from serial undiluted passage, J. Virol. 31: 231.PubMedGoogle Scholar
  271. Stinski, M.F., Mocarski„E.S., Thomsen, D.R., and Urbanowski, M.L., 1979b, Membrane glycoproteins and antigens induced by human cytomegalovirus, J. Gen. Virol. 43: 119.Google Scholar
  272. Summers, W.C., 1980, Molecular epidemiology of DNA viruses: Applications of restriction endonuclease cleavage site analysis, Yale J. Biol. Med. 53: 55.PubMedGoogle Scholar
  273. Swack, N.S., Liu, O.C., and Hsiung, G.D., 1971, Cytomegalovirus infections of monkeys and baboons, Am. J. Epidemiol. 94: 397.PubMedGoogle Scholar
  274. Sweet, G.H., Tegtmeier, G.E., and Bayer, W.L., 1979, Antigens of human cytomegalovirus: Electroimmunodiffusion assay and comparison among strains, J. Gen. Virol. 43: 707.PubMedGoogle Scholar
  275. Talbot, P., and Almeida, J.D., 1977, Human cytomegalovirus: Purification of enveloped virions and dense bodies, J. Gen. Virol. 36: 345.PubMedGoogle Scholar
  276. Tanaka, S., Furukawa, T., and Plotkin, S.A., 1975, Human cytomegalovirus stimulates host cell RNA synthesis, J. Virol. 15: 297.PubMedGoogle Scholar
  277. Tanaka, S., Ihara, S., and Watanabe, Y., 1978, Human cytomegalovirus induces DNA-dependent RNA polymerases in human diploid cells, Virology 89: 179.PubMedGoogle Scholar
  278. Tanaka, S., Otsuka, M., Ihara, S., Maeda, F., and Watanabe, Y., 1979, Induction of pre-early nuclear antigen(s) in HEL cells infected with human cytomegalovirus, Microbiol. Immunol. 23: 263.PubMedGoogle Scholar
  279. Tegtmeyer, P.J., and Craighead, J.E., 1968, Infection of adult mouse macrophages in vitro with cytomegalovirus, Proc. Soc. Exp. Biol. Med. 129: 690.PubMedGoogle Scholar
  280. Tenser, R.B., and Hsiung, G.D., 1976, Comparison of guinea pig cytomegalovirus and guinea pig herpes-like virus: Pathogenesis and persistence in experimentally infected animals, Infect. Immun. 13: 934.PubMedGoogle Scholar
  281. The, T.H., Klein, G., and Langenhuysen, M.M.A.C., 1974, Antibody reactions to virus-specific early antigens (EA) in patients with cytomegalovirus (CMV) infection, Clin. Exp. Immunol. 16: 1.PubMedGoogle Scholar
  282. Tinghitella, T.J., and Booss, J., 1979, Enhanced immune response late in primary cytomegalovirus infection of mice, J. Immunol. 122: 2442.PubMedGoogle Scholar
  283. Tocci, M.J., and St. Jeor, S.C., 1979a, Susceptibility of lymphoblastoid cells to infection with human cytomegalovirus, Infect. Immun. 23: 418.Google Scholar
  284. Tocci, M.J., and St. Jeor, S.C., 1979b, Persistence and replication of the human cytomegalovirus genome in lymphoblastoid cells of B and T origin, Virology 96: 664.Google Scholar
  285. Tyms, A.S., and Williamson, J.D., 1980, Polyamine metabolism in MRC-5 cells infected with human cytomegalovirus, J. Gen. Virol. 48: 183.PubMedGoogle Scholar
  286. Valicek, L., Smíd, B., Pleva, V., and Mensík, J., 1970, Porcine cytomegalic inclusion disease virus, Arch. Gesamte Virusforsch. 32: 19.PubMedGoogle Scholar
  287. Vonka, V., Anisimovâ, E., and Macek, M., 1976, Replication of cytomegalovirus in human epithelioid diploid cell line, Arch. Virol. 52: 283.PubMedGoogle Scholar
  288. Wahren, B., and Hberg, B., 1979, Inhibition of cytomegalovirus late antigens by phosphonoformate, Intervirology 12: 335.Google Scholar
  289. Waner, J.L., 1975, Partial characterization of a soluble antigen preparation from cells infected with human cytomegalovirus: Properties of antisera prepared to the antigen, J. Immunol. 114: 1454.PubMedGoogle Scholar
  290. Waner, J.L., and Biano, S.A., 1979, Antibody reactivity to human and vervet cytomegalovirus early antigen(s) in sera from patients with active cytomegalovirus infections and from asymptomatic donors, J. Clin. Microbiol. 9: 134.PubMedGoogle Scholar
  291. Waner, J.L., and Budnick, J.E., 1977, Blastogenic response of human lymphocytes to human cytomegalovirus, Clin. Exp Immunol. 30: 44.PubMedGoogle Scholar
  292. Waner, J.L., and Weller, T.H., 1974, Behavior of human cytomegaloviruses in cell cultures of bovine and simian origin, Proc. Soc. Exp. Biol. Med. 145: 379.PubMedGoogle Scholar
  293. Waner, J.L., and Weller, T.H., 1978, Analysis of antigenic diversity among human cytomegaloviruses by kinetic neutralization tests with high-titered rabbit antisera, Infect. Immun. 21: 151.PubMedGoogle Scholar
  294. Waner, J.L., Budnick, J.E., and Albrecht, T.B., 1978, Effect of rhesus or vervet cytomegalovirus infection on DNA synthesis in untreated and 5-iodo-2’-deoxyuridine-arrested cells, J. Virol. 25: 465.PubMedGoogle Scholar
  295. Weller, T.H., Macauley, J.C., Craig, J.M., and Wirth, P., 1957, Isolation of intranuclear inclusion producing agents from infants with illnesses resembling cytomegalic inclusion disease, Proc. Soc. Exp. Biol. Med. 94: 4.PubMedGoogle Scholar
  296. Wentworth, B.B., and French, L., 1970, Plaque assay of cytomegalovirus strains of human origin, Proc. Soc. Exp. Biol. Med. 135: 253.PubMedGoogle Scholar
  297. Williams, L.L., Blakeslee, J.R., Jr., Boldogh, I., and Huang, E.S., 1980, Detection of cytomegalovirus genomes in human skin fibroblasts by DNA hybridization, J. Gen. Virol. 51: 435.PubMedGoogle Scholar
  298. Wise, T.G., Manischewitz, J.E., Quinnan, G.V., Aulakh, G.S., and Ennis, F.A., 1979, Latent cytomegalovirus infection of BALB/c mouse spleens detected by an explant culture technique, J. Gen. Virol. 44: 551.PubMedGoogle Scholar
  299. Wright, H.T., Jr., 1973, Cytomegaloviruses, in: The Herpesviruses A.S. Kaplan, ed.), pp. 353–388, Academic Press, New York.Google Scholar
  300. Wright, H.T., jr., Goodheart, C.R., and Lielausis, A., 1964, Human cytomegalovirus: Morphology by negative staining, Virology 23: 419.PubMedGoogle Scholar
  301. Wright, H.T., Kasten, F.H., and McAllister, R.M., 1968, Human cytomegalovirus: Observations of intracellular lesion development as revealed by phase contrast, time-lapse cinematography, Proc. Soc. Exp. Biol. Med. 127: 1032.PubMedGoogle Scholar
  302. Wroblewska, Z., Gilden, D., Devlin, M., Huang, E.-S., Rorke, L.B., Hamada, T., Furukawa, T., Cummins, L., Kalter, S., and Koprowski, H., 1979, Cytomegalovirus isolation from a chimpanzee with acute demyelinating disease after inoculation of multiple sclerosis brain cells, Infect. Immun. 25: 1008.PubMedGoogle Scholar
  303. Wu, B., and Ho, M., 1979, Characteristics of infection of B and T lymphocytes from mice after inoculation with cytomegalovirus, Infect. Immun. 24: 856.PubMedGoogle Scholar
  304. Wu, B.C., Dowling, J.N., Armstrong, J.A., and Ho, M., 1975, Enhancement of mouse cytomegalovirus infection during host-versus-graft reaction, Science 190: 56.PubMedGoogle Scholar
  305. Yamanishi, K., and Rapp, F., 1979a, Production of plasminogen activator by human and hamster cells infected with human cytomegalovirus, J. Virol. 31: 415.PubMedGoogle Scholar
  306. Yamanishi, K., and Rapp, F., 1979b, Induction of host DNA synthesis and DNA polymerase by DNA-negative temperature-sensitive mutants of human cytomegalovirus, Virology 94: 237.PubMedGoogle Scholar
  307. Yamanishi, K., Fogel, M., and Rapp, F., 1978, Effect of caffeine on the replication of non-irradiated and ultraviolet-irradiated cytomegalovirus, Intervirology 10: 241.PubMedGoogle Scholar
  308. Yamashiroya, H.M., Reed, J.M., Blair, W.H., and Schneider, M.D., 1971, Some clinical and microbiological findings in vervet monkeys (Cercopithecus aethiops pygerythrus), Lab. Anim Sci. 21: 873.PubMedGoogle Scholar
  309. Young, J.A., Cheung, K.-S., and Lang, D.J., 1977, Infection and fertilization of mice after artificial insemination with a mixture of sperm and murine cytomegalovirus, J. Infect. Dis. 135: 837.PubMedGoogle Scholar
  310. Zablotney, S.L., Wentworth, B.B., and Alexander, E.R., 1978, Antigenic relatedness of 17 strains of human cytomegalovirus, Am. J. Epidemiol. 107: 336.PubMedGoogle Scholar
  311. Závada, V., Erban, V., Rezácová, D., and Vonka, V., 1976, Thymidine-kinase in cytomegalovirus infected cells, Arch. Virol. 52: 333.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Fred Rapp
    • 1
  1. 1.Department of Microbiology and Cancer Research CenterThe Pennsylvania State University College of MedicineHersheyUSA

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