Sister Chromatid Exchange in Human Lymphocytes as an Indicator of DNA Damage and Repair in Vivo
The development of staining techniques for the demonstration of sister chromatid exchanges (SCE) (1) has introduced a new, promising tool in the evaluation of genotoxic effects of mutagenic and carcinogenic agents. SCEs arise when the two chromatids within a single chromosome exchange segments (Fig. 1). This usually occurs at homologous loci, so the SCE itself may not alter the genetic information of the cell or its daughter cells. In fact, SCEs may represent a natural event of mitotic recombination, since present evidence suggests that SCE occurs at a very low frequency in normal somatic cells (2).
KeywordsEthylene Oxide Ethylene Oxide Human Lymphocyte Chromosome Aberration Heavy Smoker
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