DNA Repair in Some Cancer-Prone Conditions and in Patients with Cutaneous Malignancies
Increasing evidence suggests that human cancer and mutation may arise as a consequence of environmental exposure to chemical and physical agents (1, 2). Many of these agents probably exert their carcinogenic and mutagenic properties by a direct or indirect interaction with the genetic material (3). A number of structural modifications of the DNA can be overcome by cellular repair mechanisms (4). If these DNA repair mechanisms are defective, or if they are not able to restore the original DNA molecule without causing errors in the DNA sequence, mutations and neoplasms may result (5). Thus, DNA repair mechanisms should be considered as important biological defence mechanisms against mutagenic and carcinogenic events.
KeywordsBasal Cell Carcinoma Actinic Keratosis Chronic Lymphatic Leukaemia Repair Synthesis Cutaneous Malignancy
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