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Immunoregulatory T Cell Subpopulations in Man

  • M. C. Mingari
  • A. Moretta
  • W. G. Canonica
  • M. Colombatti
  • L. Moretta

Abstract

A large number of experimental evidence has been collected indicating that thymus derived (T) lymphocytes are by no means an homogeneous cell population. These cells mediate a spectrum of immune responses such as delayed hypersensitivity, graft rejection, and antineoplastic and antiparasitic immunity. In addition they play a central role in humoral immunity by regulating B cell responses in both positive (helper) and negative (suppressor) ways (Gershon, 1974). In mice these various properties have been attributed to distinct subclasses of T lymphocytes identified by different membrane markers. The most promising marker for the identification of functional subsets of T cells has been the Ly antigen system. T cells bearing Ly 1 alloantigen show helper activity in B cell responses, respond in mixed lymphocyte reactions to determinants coded for by the I and S regions, and are the effector cells in delayed hypersensitivity reactions. Ly 2 and 3 alloantigens are present on suppressor T cells and on CTL, and respond in MLR by recognizing K and D region products on the allogeneic target cells (Cantor and Boyse, 1975 a, b; Cantor and Boyse, 1977; Huber et al., 1976).

Keywords

Cell Subpopulation Juvenile Rheumatoid Arthritis Mixed Lymphocyte Reaction Severe Combine Immunodeficiency Distinct Subclass 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • M. C. Mingari
    • 1
  • A. Moretta
    • 1
  • W. G. Canonica
    • 1
  • M. Colombatti
    • 1
    • 2
  • L. Moretta
    • 1
  1. 1.Università di GenovaGenovaItaly
  2. 2.Istituto di Microbiologia del l’Università e I.S.M.I.Italy

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