Immunoregulatory T Cell Subpopulations in Man
A large number of experimental evidence has been collected indicating that thymus derived (T) lymphocytes are by no means an homogeneous cell population. These cells mediate a spectrum of immune responses such as delayed hypersensitivity, graft rejection, and antineoplastic and antiparasitic immunity. In addition they play a central role in humoral immunity by regulating B cell responses in both positive (helper) and negative (suppressor) ways (Gershon, 1974). In mice these various properties have been attributed to distinct subclasses of T lymphocytes identified by different membrane markers. The most promising marker for the identification of functional subsets of T cells has been the Ly antigen system. T cells bearing Ly 1 alloantigen show helper activity in B cell responses, respond in mixed lymphocyte reactions to determinants coded for by the I and S regions, and are the effector cells in delayed hypersensitivity reactions. Ly 2 and 3 alloantigens are present on suppressor T cells and on CTL, and respond in MLR by recognizing K and D region products on the allogeneic target cells (Cantor and Boyse, 1975 a, b; Cantor and Boyse, 1977; Huber et al., 1976).
KeywordsCell Subpopulation Juvenile Rheumatoid Arthritis Mixed Lymphocyte Reaction Severe Combine Immunodeficiency Distinct Subclass
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