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Enzymes from Calf Thymus That Might Be Involved in DNA Repair

  • Francesco Campagnari

Abstract

The DNA molecules carrying the genetic information of cells are susceptible to damage by radiation of certain wavelengths, such as X-, γ- and UV-rays (see for review: Latarjet, 1972; Blok and Loman, 1974; Murphy, 1974), and by organic chemicals that themselves or through their metabolic products react with nucleic acids as strong electrophiles (Miller and Miller, 1966; Miller, 1970). Living cells exposed to these noxious agents undergo functional inactivation, enhancement of the mutation rate and decrease of survival. In vertebrate animals the lesions of DNA may initiate complex processes of cell transformation that will eventually lead to cancer. Radiation and substances that directly or indirectly alter the molecules of DNA are potentially mutagenic and carcinogenic, thus behaving as genetic toxins. Detrimental agents of this type are natural or artificial components of the environment in which we all presently live.

Keywords

Excision Repair Xeroderma Pigmentosum Pyrimidine Dimer Thymine Dimer Postreplication Repair 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Francesco Campagnari
    • 1
  1. 1.Laboratory of BiochemistryBiology Group Ispra, D.G.XII, C.E.C., Joint Research CentreIspra (Va)Italy

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