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Enzymes from Calf Thymus That Might Be Involved in DNA Repair

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Lymphocyte Stimulation

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Abstract

The DNA molecules carrying the genetic information of cells are susceptible to damage by radiation of certain wavelengths, such as X-, γ- and UV-rays (see for review: Latarjet, 1972; Blok and Loman, 1974; Murphy, 1974), and by organic chemicals that themselves or through their metabolic products react with nucleic acids as strong electrophiles (Miller and Miller, 1966; Miller, 1970). Living cells exposed to these noxious agents undergo functional inactivation, enhancement of the mutation rate and decrease of survival. In vertebrate animals the lesions of DNA may initiate complex processes of cell transformation that will eventually lead to cancer. Radiation and substances that directly or indirectly alter the molecules of DNA are potentially mutagenic and carcinogenic, thus behaving as genetic toxins. Detrimental agents of this type are natural or artificial components of the environment in which we all presently live.

This publication is contribution No 1667 of the Programme Biology, Radiation Protection and Medical Research, Directorate General XII for Research, Science and Education of the Commission of the European Communities.

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Authors and Affiliations

  1. Laboratory of Biochemistry, Biology Group Ispra, D.G.XII, C.E.C., Joint Research Centre, 21020, Ispra (Va), Italy

    Francesco Campagnari

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  1. Francesco Campagnari
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  1. Division of Radiation Protection, CNEN - CSN Casaccia, Rome, Italy

    Amleto Castellani

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© 1980 Plenum Press, New York

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Campagnari, F. (1980). Enzymes from Calf Thymus That Might Be Involved in DNA Repair. In: Castellani, A. (eds) Lymphocyte Stimulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6997-4_11

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  • DOI: https://doi.org/10.1007/978-1-4684-6997-4_11

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