Enzyme Activity at a Gas Solid Interphase: Oxidation of Methanol to Formaldehyde

  • Miguel Cedeno
  • Mario Waissbluth


Methanol-consuming yeasts have an FAD-dependent methanol oxidase, which catalyzes the reaction between methanol and oxygen to form formaldehyde and hydrogen peroxide. The catalâse that is present in the same peroxisomes decomposes the hydrogen peroxide; it also acts as a formaldehyde producer by oxidation of the methanol (1,2). A subsequent enzymatic step incorporates formaldehyde into different metabolic pathways through an NADH2 - dependent formaldehyde dehydrogenase, which requires a mechanism for NAD regeneration. Therefore, non-viable cells will not decompose formaldehyde since the NAD cannot be regenerated (1).


Methanol Oxida Methanol Vapor Methanol Feed Exceptional Stability Initial Reaction Velocity 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Miguel Cedeno
    • 1
  • Mario Waissbluth
    • 1
  1. 1.Centro de Investigacion y Estudios AvanzadosInstituto Politecnico NacionalMexico, D.F.Mexico

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