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Steroid Conversion Using Immobilized Living Microorganisms

  • P. O. Larsson
  • S. Ohlson
  • K. Mosbach

Abstract

In steroid transformations some of the advantages of immobilized microorganisms seem to be especially important, since the manufacture of steroid drugs often involves very expensive intermediates and products (1). Therefore, we have been studying two corticosteroid transformations. The first reaction is an 11-β-hydroxylation catalyzed by free or polyacrylamide immobilized Curvularia lunata, producing cortisol from Reichstein’s S (cortexolon) (1, 2). The second reaction is a 3-ketosteroid-Δ1-dehydrogenation of cortisol to predniso’one catalyzed by free or polyacrylamide immobilized Anthnobacten simplex (3, 4).

Keywords

Ammonium Persulphate Steroid Drug Artificial Electron Acceptor Activation Coloni Immobilize Microorganism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    LARSSON, P.O. & MOSHBACH, K.: Meth. in Bnzymokogy 44: 183, 1976.CrossRefGoogle Scholar
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • P. O. Larsson
    • 1
  • S. Ohlson
    • 1
  • K. Mosbach
    • 1
  1. 1.Chemical CenterUniversity of LundLundSweden

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