Steroid Conversion Using Immobilized Living Microorganisms
In steroid transformations some of the advantages of immobilized microorganisms seem to be especially important, since the manufacture of steroid drugs often involves very expensive intermediates and products (1). Therefore, we have been studying two corticosteroid transformations. The first reaction is an 11-β-hydroxylation catalyzed by free or polyacrylamide immobilized Curvularia lunata, producing cortisol from Reichstein’s S (cortexolon) (1, 2). The second reaction is a 3-ketosteroid-Δ1-dehydrogenation of cortisol to predniso’one catalyzed by free or polyacrylamide immobilized Anthnobacten simplex (3, 4).
KeywordsAmmonium Persulphate Steroid Drug Artificial Electron Acceptor Activation Coloni Immobilize Microorganism
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