Abstract
N-acetyl-DL-tryptophan is produced (1) by room temperature condensation of DL-serine and indole in the presence of acetic acid and acetic anhydride at 62% yield. A part of-the unreacted indole is easily extracted with ether and recycled. The overall conversion of indole is 85%. The DL-serine is the product of a method developed in Snamprogetti laboratories (2). The acetyl-DL-tryptophan in turn is asymmetrically hydrolyzed by acylase entrapped in cellulose triacetate fibers to produce L-tryptophan and acetyl-D-tryptophan.
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References
GHOSAL, S. J. Indian Chem. Svc 41: 496, 1964.
German Patent No. 2,515,622; Chem. Abe 84:31496e, 1976).
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© 1978 Plenum Press, New York
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Bartoli, F., Bianchi, G.E., Zaccardelli, D. (1978). Production of L-Tryptophan. In: Broun, G.B., Manecke, G., Wingard, L.B. (eds) Enzyme Engineering. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6985-1_57
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DOI: https://doi.org/10.1007/978-1-4684-6985-1_57
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