Immobilization of Neuraminidase for the Treatment of Tumor Cells

  • Edward R. Bazarian
  • Lemuel B. WingardJr.


A promising approach to tumor immunotherapy is based on using neuraminidase treated cells to stimulate the immune response of the patient (1). In this technique tumor cells are incubated in vitro with Vibrio cholerae neuraminidase (VCN) and then injected into a patient or test animal possessing the same type of tumor. Remission has been observed with several types of tumor (1, 2).


Sialic Acid Immobilize Enzyme Test Animal Cell Surface Antigen Soluble Enzyme 


  1. 1.
    SEDLACEK, H.H., SEILER, F.R., & SCHWICK, H.G. Klin.Wschn. 55:199,1977.CrossRefGoogle Scholar
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    HOLLAND, J. F. & BEKESI,J.G. Med. Clin. Nonth America 60: 539, 1976.Google Scholar
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    CAMPBELL, J., HORNBY, W.E. & MORRIS, D. L. Biochim. Biaphye. Acta 384: 307, 1975.CrossRefGoogle Scholar
  4. 4.
    WARREN, L. J. Biol. Chem. 234: 1971, 1959.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Edward R. Bazarian
    • 1
  • Lemuel B. WingardJr.
    • 1
  1. 1.Departments of Pharmacology and Chemical EngineeringUniversity of PittsburghPittsburghUSA

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