Hollow Fiber-Entrapped Liver Microsomes: A Potential Extracorporeal Drug Detoxifier
We are attempting to develop an extracorporeal hollow fiber drug detoxifier (EDD) based on the NADPH-dependent, multienzyme, drug hydroxylation complex present in liver endoplasmic reticulum and isolatable in particulate form as microsomes (MS). In addition to its potential use as an EDD this system serves as a model for the use of membrane-bound, cofactor-requiring, multienzyme complexes in industrial as well as medical applications. This work also may contribute toward the development of liver assist devices as well as provide for production of drug metabolites for subsequent therapeutic screening.
KeywordsHollow Fiber Gluconic Acid Acrylic Copolymer Drug Detoxification Cellulose Acetate Fiber
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