Biomedical Applications of Enzymatic Fibres
Mono or polyenzymatic systems immobilized in cellulose triacetate fibers were investigated in our laboratories for applications in the biomedical field. These systems were investigated for analytical uses, particularly for the correction of pathological situations that require the continuous monitoring of blood glucose. Another potentially important application is the elimination of toxic metabolites in some pathological situations, such as liver coma. To attain this it was necessary to develop biocompatible fibers; this was achieved through physically blending a suitable platelet antiaggregant to the polymeric matrix before spinning the fibers. These biocompatible fibers then were used with success for the elimination of ammonia and aromatic aminoacids from blood serum. A further improvement of this technique was the chemical binding of the employed platelet antiaggregant to various polymeric surfaces.
KeywordsPhenylalanine Ammonia Lyase Pathological Situation Cellulose Triacetate Liver Coma Nylon Tube
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