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Enzyme-Polyethylene Glycol Adducts: Modified Enzymes with Unique Properties

  • F. F. Davis
  • A. Abuchowski
  • T. van Es
  • N. C. Palczuk
  • R. Chen
  • K. Savoca
  • K. Wieder

Abstract

There are many clinical disorders which, in theory might be treated by the use of appropriate enzymes. However, there are serious problems associated with enzyme therapy. First, inadequate amounts of human enzymes are available; and most foreign enzymes are immunogenic in humans. They can be administered only a few times. Second, the circulating life in the blood may be very short even on the first injection (often a matter of a few minutes). And third, the cost of highly purified enzymes may be too great to allow general use.

Keywords

Bovine Liver Human Enzyme Cyanuric Chloride Enzyme Therapy Inadequate Amount 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    ABUCHOWSKI, A., VAN ES, T., PALCZUK, N.C., & DAVIS, F.F. J. Biot. Chem. 252: 3578, 1977.Google Scholar
  2. 2.
    ABUCHOWSKI, A., MCCOY, J.R., PALCZUK, N.C., VAN ES, T., & DAVIS, F.F. J. Biot. Chem. 252: 3582, 1977.Google Scholar
  3. 3.
    OUCHTERLONY, O. in “Handbook for Experimental Immunology,” (D.M. Weir, ed.), F.A. Davis Co., Philadelphia, 1967, p. 655.Google Scholar
  4. 4.
    DRESSER, D.W. & WORTIS, H.H. in “Handbook of Experimental Immunology,” (D.M. Weir, ed.), F.A. Davis Co., Philadelphia, 1967, p. 1054.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • F. F. Davis
    • 1
  • A. Abuchowski
    • 1
  • T. van Es
    • 1
  • N. C. Palczuk
    • 1
  • R. Chen
    • 1
  • K. Savoca
    • 1
  • K. Wieder
    • 1
  1. 1.Departments of Biochemistry and Zoology and Bureau of Biological ResearchRutgers UniversityNew BrunswickUSA

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