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Hemisynthesis of Aminoglycosides

  • F. Le Goffic
  • J. F. Le Bigot
  • S. Sicsic
  • C. Vincent

Abstract

It is well known (1) that one of the processes of inactivation of aminoglycosides by some bacteria is a structural modification of these antibiotics, e.g. N-acetylation, o-adenylylation, o-phosphorylation. The study of the structure activity relationship requires the preparation of specifically modified aminoglycosides at one of the amino or hydroxyl functions. The only way to obtain such specificity is by enzymatic reactions. We therefore used enzymes isolated from resisting bacterial strains, performing specific modification of aminoglycosides. We thus modified Gentamicin, Sisomicin and Tobramycin.

Keywords

Bacterial Strain Enzymatic Reaction Structure Activity Relationship Specific Modification DEAE Cellulose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    PRICE, K.E., GODFREY, J.C. & KAWAGUCHI, H. in “Advances in Applied Microbiology,” vol. 18 ( W.W. Umbreit, ed.), Academic Press, New York, 1974, p. 191.Google Scholar
  2. 2.
    BROUN, G., THOMAS, D., GELFF, G., DOMURADO, D., BERJONNEAU, A.M. & GUILLON, C. Bi.otechnot. Bioeng. 15: 359, 1973.CrossRefGoogle Scholar
  3. 3.
    LE GOFFIC, F., SICSIC, S. & VINCENT, C. Tetnahednon Ltns. 33: 2845, 1976.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • F. Le Goffic
    • 1
  • J. F. Le Bigot
    • 1
  • S. Sicsic
    • 1
  • C. Vincent
    • 1
  1. 1.Centre d’Etudes et de Recherches de Chimie Organique AppliqueeCNRSThiaisFrance

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