Economical Aspects of Continuous Operation with Biocatalysis

  • E. Flaschel
  • C. Wandrey


Since synthetic membranes for ultrafiltration are available in high-area-modules, continuous operation with native enzymes in membrane reactors will become an interesting alternative to continuous operation with covalently bound enzymes even on an industrial scale. Continuous operation has been studied with native and carrier-fixed acylase used for optical resolution of methionine by stereospecific hydrolysis of N-acetyl-D,L-methionine (1,2). In this report the data obtained are used to evaluate the economical aspects of different operational methods.


Unit Weight Economical Aspect Continuous Operation Native Enzyme Plug Flow Reactor 
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    WANDREY, C., FLASCHEL, E., SCHUGERL, K., Chem. Ing. Tech 49(3): 257, 1977.CrossRefGoogle Scholar
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    WANDREY, C., Inaugural dissertation, Tech. Univ. Hannover, F.R. Germany, 1977.Google Scholar
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    HOOKE, R. & JEEVES, T.Z. J. Assoc. Comp. Mach 8(2): 212, 1961.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • E. Flaschel
    • 1
  • C. Wandrey
    • 2
  1. 1.Ecole Polytechnique Federale de LausanneSwitzerland
  2. 2.Technischen Universitat HannoverFederal Republic of Germany

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